DRSC/TRiP Functional Genomics Resources

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Protein Alignment EHMT2 and G9a

DIOPT Version :10

Sequence 1:XP_006715037.2 Gene:EHMT2 / 10919 HGNCID:14129 Length:1395 Species:Homo sapiens
Sequence 2:NP_001259088.1 Gene:G9a / 30971 FlyBaseID:FBgn0040372 Length:1657 Species:Drosophila melanogaster


Alignment Length:1483 Identity:404/1483 - (27%)
Similarity:608/1483 - (40%) Gaps:348/1483 - (23%)


- Green bases have known domain annotations that are detailed below.


Human   112 PPPPLLSA--PEMRGLPRGRGLMRARGRGRAAPPGSRGRGRGGPHRGRGRPRSLLSLPRAQASWT 174
            |..|.|:|  ||....|                         .|.|||||.|.:          .
  Fly   318 PDKPSLTALSPEENSAP-------------------------APKRGRGRARKI----------R 347

Human   175 PQLSTGLTSPPVPCLPSQGEAP-----------------AEMGALLLEKETRGAT---------- 212
            |......:...:||..|.||..                 :::..:..|:|..|..          
  Fly   348 PDAEVETSEVILPCEDSLGEKKPGRKRKLPDEPIDQQQLSDLVVVKTEQEELGDAPLGDVKRMRR 412

Human   213 -----ERVH--GSLGDTPRSEETLPKATPDSLEPAGPSSPASVT-----VTVGDEGADTP----- 260
                 .|:|  ||..:..::|...|       :|:...|.|.||     :.|.||  .||     
  Fly   413 SVRLGNRLHADGSPWEEVKTEALHP-------QPSAELSFAEVTSEILPLAVLDE--KTPPKKRG 468

Human   261 -VGATPLIGDESENLEGDGDLRGGRILLGHATKSFPSSPSKGGSC----PSRAKMSMTGAGKSPP 320
             ...||.:..|||...|        :...:..|...||    |.|    |.|:|..:.   .:|.
  Fly   469 RKAKTPCVKLESETSCG--------LPFANGNKKTNSS----GGCELQLPKRSKRRIK---PTPK 518

Human   321 SVQSLAMR-------LLSMPGAQGAAAAGSEPPPATTSPEGQPKVHRARKTMSKPGN---GQPPV 375
            .:::..:|       :..|...:.|||...:....||...|.......:|:....|:   |.|. 
  Fly   519 ILENDELRCEFETKHIERMTQWESAAAVDGDFETPTTGGNGSNSSTSRQKSDKSDGSNFEGGPG- 582

Human   376 PEKRPPEIQHFRMSDDVHSLGKVTSDLAKRRKLNSGGGLSEELGSARRSGEVTLTKGDPGSLEEW 440
                             |..|  ||.:.||.       .|:........|...|.|.......:.
  Fly   583 -----------------HPAG--TSAIKKRL-------FSKSQRDIENYGAAMLAKSKLPPCPDV 621

Human   441 ETVVGDDFSLYYDSYSVDERVDSDSKSEVEALTEQLSEEEEEEEEEEEEEEEEEEEEEEEEDEES 505
            |..:.|..:         .|::::...|...|.:   :::.:..:::|:..:....::...||.|
  Fly   622 EQFLNDIKA---------SRINANRSPEERKLNK---KQQRKLAKQKEKHLKHLGLQKNHRDEPS 674

Human   506 GNQSDRSGS-------------SGRRKAKKKWRKDSPWVKPSRKRRKREPPRAKEPR--GVNGVG 555
            .|.|..:.:             |...:.:....|:.|.....:.||......||..|  |....|
  Fly   675 DNDSSNTDNEFFPTTRVQVGKPSVTLRVRNSVTKELPTTATLKSRRNPVVQAAKLTRRIGARAAG 739

Human   556 SSGPSEYMEVPLGSLELPSEGTLSPNHAGVSNDTSSLETERGFEELP--------LCSCRMEAPK 612
            ....:....||:.:   |....|......:..|.:.:   |..:..|        :|.|:..:..
  Fly   740 EVTEAARASVPIST---PDAEQLHSLDTSIQADVTPI---RDLDMRPSTSRVSKFICLCQKPSQY 798

Human   613 IDRISERAGHKCMATESVDGELSGCNAAILK--RETMRPSSRVALMVLCETHRARMVKHHCCPGC 675
            ..|.:..:.: |.|.:.:|.:..||...:..  ...:|||.||:.|:||:.|:.|:..|:||.||
  Fly   799 YARNAPDSSY-CCAIDHIDDQKIGCCNELSSEVHNLLRPSQRVSYMILCDEHKKRLQSHNCCAGC 862

Human   676 GYFCTAGTFLECHPDFRVAHRFHKACVSQL---------------NGMVF--------CPHCGED 717
            |.|||.|.|:.|    :..|.||..|..:.               .|:.|        |||||.|
  Fly   863 GIFCTQGKFVLC----KQQHFFHPDCAQRFILSTSYEKELGDEEDQGVKFSSPVLVLKCPHCGLD 923

Human   718 ASEAQEVTIPRGDGVTPPAGTAAPAPPPLSQD----VPGRADTSQ-------------PSARMRG 765
            ..|       |...||....:   .|..|...    .|.|..||.             |.|..|.
  Fly   924 TPE-------RTSTVTMKCQS---LPVFLRTQKYKIKPARLTTSSHLTQFGTVENANTPGATARN 978

Human   766 HGEPRRPPCDPLADTIDSSGPSLTLPNGGCLSAVGLPLGPGREALEK---ALVIQESERRKKLRF 827
            .|..      ..|.|:.::....:..||......|......|.||..   |.:|.||.....||.
  Fly   979 KGGL------STAVTLSAASSPASKTNGAQRGRAGTSNSNSRHALNSINFAQLIPESVMNVVLRG 1037

Human   828 H-------------PRQLYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEIC 879
            |             ||.:|.:|:..:|::|..:|..:.:......:....|.||..|..|::::.
  Fly  1038 HVVSASGRVTAEFTPRDMYYAVQNDDLERVAEILAADFNVLTPIREYLNGTCLHLVAHSGTLQMA 1102

Human   880 HVLLQAGAN----INAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIG 940
            ::||..||:    :|.||.:.||.||.||:|...::....:|.|..|..|..||.|.||.||::|
  Fly  1103 YLLLCKGASSPDFVNIVDYELRTALMCAVMNEKCDMLNLFLQCGADVAIKGPDGKTSLHIAAQLG 1167

Human   941 NLEMVSLLLSTGQVD---------VNAQDSGGWTPIIWAAEHKHIEVIRM--------------- 981
            |||...|::.:.:..         ::|||.||||.::||||..|.:::|:               
  Fly  1168 NLEATQLIVDSYRTSRNITSFLSFIDAQDEGGWTAMVWAAELGHTDIVRLASLPQAVFLKLINIF 1232

Human   982 -----LLTRGADVTLTDNVSERLVEEENICLHWASF--TGSAAIAEVLLNARCDLHAVNYHGDTP 1039
                 ||.:.||..:.||       :.|..|||::.  .|...|. |||.:..|.:..|..||||
  Fly  1233 LFISFLLNQDADPNICDN-------DNNTVLHWSTLHNDGLDTIT-VLLQSGADCNVQNVEGDTP 1289

Human  1040 LHIAARESYHDCVLLFLSRGANPELRNKEGDTAWDLTP-ERSD----VWFALQLNRKLRLGVGNR 1099
            ||||.|.|.....:..::.||:..::||.....:|..| |.|:    |.|.:|:.....||    
  Fly  1290 LHIACRHSVTRMCIALIANGADLMIKNKAEQLPFDCIPNEESECGRTVGFNMQMRSFRPLG---- 1350

Human  1100 AIRTEKIICRDVARGYENVPIPCVNG----------VDGEPCPEDYKYISENC--ETSTMNIDRN 1152
             :|| .::|.|.:.|.|..||..|..          .|....| |::|::: |  :.:::.|||.
  Fly  1351 -LRT-FVVCADASNGREARPIQVVRNELAMSENEDEADSLMWP-DFRYVTQ-CIIQQNSVQIDRR 1411

Human  1153 ITHLQHCTCVDDCSSSNCLCGQLSIRCWYDKDGRLLQEFNKIEPPLIFECNQACSCWR-NCKNRV 1216
            ::.::.|:|:|.|||..|.|...|.:.||..:.||..:||..:|.:|||||..|.|.: :|||||
  Fly  1412 VSQMRICSCLDSCSSDRCQCNGASSQNWYTAESRLNADFNYEDPAVIFECNDVCGCNQLSCKNRV 1476

Human  1217 VQSGIKVRLQLYR---TAKMGWGVRALQTIPQGTFICEYVGELISDAEADVREDDSYLFDLDNKD 1278
            ||:|.:..||:..   .|| |||||||..:|:|||:..|.||:::..|||.|.||||.|||||. 
  Fly  1477 VQNGTRTPLQIVECEDQAK-GWGVRALANVPKGTFVGSYTGEILTAMEADRRTDDSYYFDLDNG- 1539

Human  1279 GEVYCIDARYYGNISRFINHLCDPNIIPVRVFMLHQDLRFPRIAFFSSRDIRTGEELGFDYGDRF 1343
               :||||.||||::||.||.|:||::|||||..|||.|||:|||||.|||..|||:.||||::|
  Fly  1540 ---HCIDANYYGNVTRFFNHSCEPNVLPVRVFYEHQDYRFPKIAFFSCRDIDAGEEICFDYGEKF 1601

Human  1344 WDIKSKYFT-CQCGSEKCKHSAEAIALEQSRLARLDPHPELLPELGSLPPVNT 1395
            |.::.:... |:|.:..||:::::.:...|. ......||  .|.|:|...||
  Fly  1602 WRVEHRSCVGCRCLTTTCKYASQSSSTNASP-TNATTAPE--NETGTLSSTNT 1651

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
EHMT2XP_006715037.2 PHA03247 <126..382 CDD:223021 60/314 (19%)
2A1904 <396..504 CDD:273344 16/107 (15%)
EHMT_ZBD 598..727 CDD:411018 44/161 (27%)
ANKYR 806..1072 CDD:440430 96/316 (30%)
ANK repeat 864..893 CDD:293786 10/32 (31%)
ANK repeat 928..960 CDD:293786 13/40 (33%)
ANK repeat 962..993 CDD:293786 14/50 (28%)
ANK repeat 1002..1033 CDD:293786 10/32 (31%)
ANK repeat 1035..1066 CDD:293786 12/30 (40%)
SET_EHMT2 1133..1371 CDD:380931 115/244 (47%)
G9aNP_001259088.1 PTZ00121 <68..>188 CDD:173412
EHMT_ZBD 786..933 CDD:411018 45/158 (28%)
ANKYR 1063..1322 CDD:440430 82/266 (31%)
ANK repeat 1088..1120 CDD:293786 10/31 (32%)
ANK repeat 1124..1153 CDD:293786 10/28 (36%)
ANK repeat 1155..1196 CDD:293786 13/40 (33%)
ANK repeat 1199..1249 CDD:293786 13/49 (27%)
ANK repeat 1251..1283 CDD:293786 10/32 (31%)
ANK repeat 1285..1316 CDD:293786 12/30 (40%)
SET_EHMT 1391..1622 CDD:380941 116/237 (49%)
Blue background indicates that the domain is not in the aligned region.

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