DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment EHMT2 and set-11

DIOPT Version :9

Sequence 1:	XP_006715037.1	Gene:	EHMT2 / 10919	HGNCID:	14129	Length:	1274	Species:	Homo sapiens
Sequence 2:	NP_001364763.1	Gene:	set-11 / 185242	WormBaseID:	WBGene00018023	Length:	278	Species:	Caenorhabditis elegans

Alignment Length:	265	Identity:	90/265 - (33%)
Similarity:	135/265 - (50%)	Gaps:	21/265 - (7%)

- Green bases have known domain annotations that are detailed below.

Human   985 IICRDVARGYENVPIPCVNG----VDGEPCPEDYKYISENCETSTMNIDRNITHLQHCTCVDDCS 1045
            ::..|:::|.|...:|..:.    :|.. ..|::||.|...:.:.....|:.:....|.|...|
Worm    19 VLYEDISQGCERFVVPVYSNPRFFMDSS-LFENFKYTSRIIDVAGQLACRSASPTFMCQCAGQC- 81

Human  1046 SSNCLC--GQLSIRCWYDKDGRLLQEFNKIEPPLIFECNQACSCWRNCKNRVVQSGIKVRLQLY- 1107
            |:||.|  |...       :|..::....:....:.|||:.|:|...|.|||.|.|....::::
Worm    82 STNCECSSGVFG-------EGGTVENMELLMWDTVRECNEYCNCALWCGNRVAQKGAMYPVEIFA 139

Human  1108 RTAKMGWGVRALQTIPQGTFICEYVGELISDAEADVREDDSYLFDLDNKDG-EVYCIDARYYGNI 1171
            |....||||||...|..||||.||.||||.|.||..|.|.::||  :.|.| |...|||:|.||.
Worm   140 RDPWCGWGVRASVDIAFGTFIGEYAGELIDDEEAMDRHDSTFLF--ETKVGSETLTIDAKYSGNY 202

Human  1172 SRFINHLCDPNIIPVRVFMLHQDLRFPRIAFFSSRDIRTGEELGFDYGDRFWDIKSKYFTCQCGS 1236
            :|||||.|.||:....:...:..::...:.||:.:.||.||||..|||:.:|  .:|.|.|.|.|
Worm   203 TRFINHSCAPNVKVANISWDYDKIQLIHMCFFTDKAIRKGEELTIDYGEAWW--ANKKFPCLCKS 265

Human  1237 EKCKH 1241
            .:|::
Worm   266 SECRY 270

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
EHMT2	XP_006715037.1	cond_enzymes	<46..>139	CDD:299129
		Ank_2	711..798	CDD:289560
		ANK	<711..762	CDD:295348
		ANK	743..862	CDD:238125
		ANK repeat	743..772	CDD:293786
		Ank_2	779..872	CDD:289560
		ANK	806..935	CDD:238125
		ANK repeat	807..839	CDD:293786
		ANK repeat	841..872	CDD:293786
		ANK repeat	881..912	CDD:293786
		Ank_5	901..954	CDD:290568
		ANK repeat	914..945	CDD:293786
		PreSET	987..1086	CDD:128744	22/104 (21%)
		SET	1102..1224	CDD:214614	53/123 (43%)
set-11	NP_001364763.1	PreSET	21..117	CDD:128744	22/104 (21%)
set-11	NP_001364763.1	SET	75..270	CDD:394802	80/206 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C161469832
Domainoid	1	1.000	96	1.000	Domainoid score	I5047
eggNOG	1	0.900	-	-		E2759_KOG1082
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D753093at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm15202
orthoMCL	1	0.900	-	-		OOG6_105922
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R211
SonicParanoid	1	1.000	-	-		X1720
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	8.680