DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment EHMT2 and ehmt2

DIOPT Version :9

Sequence 1:	XP_006715037.1	Gene:	EHMT2 / 10919	HGNCID:	14129	Length:	1274	Species:	Homo sapiens
Sequence 2:	XP_004917185.1	Gene:	ehmt2 / 100484992	XenbaseID:	XB-GENE-487387	Length:	1150	Species:	Xenopus tropicalis

Alignment Length:	1245	Identity:	775/1245 - (62%)
Similarity:	906/1245 - (72%)	Gaps:	146/1245 - (11%)

- Green bases have known domain annotations that are detailed below.

Human    73 EAPAEMGALLLEKETRGATERVHGSLGDTPRSEETLPKATPDSLEPAGPSSPASVTVTVGDEGAD 137
            ||||            |.:||:..:.|   ..:|..|:.....|         |.::..||:.|:
Frog     2 EAPA------------GESERMLSAEG---ADKEGCPERDLVGL---------SASINSGDDNAE 42

Human   138 --------TPVGATPLIGDESENLEGDGDLRG-GRILLGHATKSFPSSPSKGGS-CPSRAKMSMT 192
                    :|....|.:.::.|..:...::.. ||.|.|||:||.|:.||...| ..||||||:|
Frog    43 ELSNTREISPADVIPTVEEKEETEKESVNISPVGRGLSGHASKSLPTPPSTSSSPISSRAKMSLT 107

Human   193 GAGKSPPSVQSLAMRLLSMPGAQGAAAAGSEPPPATTSPEGQPKVHRARKTMSK----PGNGQPP 253
            |.||.|.:.||||||||::                  :.:|..||||||||:.:    ||||
Frog   108 GTGKLPHAAQSLAMRLLNI------------------TRDGADKVHRARKTIPRAVNVPGNG--- 151

Human   254 VPEKRPPEIQHFRMSDDVHSLGKVTSDLAKRRKLNSGGGLSEELGSARRSGEV----TLTKGDPG 314
             ......|.|..|...::.     |.|.....:..|...|..:: ||.:|.||    .|...:||
Frog   152 -VLVSDGEKQSVRRESEME-----TRDSPDSTQKRSSSSLVADI-SANQSREVEVSSLLLSPEPG 209

Human   315 S--------LEEWETVVGDDFSLYYDSYSVDERVDSDSKSEVEALTEQLSEEEEEEEEEEEEEEE 371
            |        .||||..||.:|||:|||:|::|:.|||||
Frog   210 SSRDPEGVDAEEWEPEVGAEFSLFYDSFSLEEQGDSDSK-------------------------- 248

Human   372 EEEEEEEEEDEESGNQSDRSGSSGRRKAKKKWRKDSPWVKPSRKRRKREPPRAKEPRGVNGVGSS 436
               |||:||:|.|||||:||.||.::|.||||:.|..|:||:|||::||  |.|....|:.||.|
Frog   249 ---EEEDEEEEGSGNQSERSSSSMKKKTKKKWKMDKAWLKPTRKRKRRE--REKPVTAVSSVGVS 308

Human   437 GPSEYMEVPLGSLELPSEGTLSPNHAGVSNDTSSLETERGFEELPLCSCRMEAPKIDRISERAGH 501
            . |||.|||||:|:||||||||||||||.|:|||::||| :|||||||||||||.:||:.|:|.:
Frog   309 N-SEYTEVPLGALDLPSEGTLSPNHAGVCNETSSMDTER-YEELPLCSCRMEAPSVDRVCEQANN 371

Human   502 KCMATESVDGELSGCNAAILKRETMRPSSRVALMVLCETHRARMVKHHCCPGCGYFCTAGTFLEC 566
            .|||||||||||||||..|.|||||||||||.||||||:|||||||||||||||||||.||||||
Frog   372 MCMATESVDGELSGCNVTITKRETMRPSSRVPLMVLCESHRARMVKHHCCPGCGYFCTTGTFLEC 436

Human   567 HPDFRVAHRFHKACVSQLNGMVFCPHCGEDASEAQEVTIPRGDGVTPPAGTAAPAPPPLSQDVPG 631
            |||||:.|||||||||.|||::||||||||||||:::||.:.|...|     .||||......||
Frog   437 HPDFRINHRFHKACVSPLNGIIFCPHCGEDASEAEQITIAKADTPVP-----IPAPPHHDGGGPG 496

Human   632 RADTSQPSARMRGHGEPRRPPCDPLADTIDSSGPSLTLPNGGCLSAVGLPLGPGREALEKALVIQ 696
            ||||:||||||||.||.:|...:..::. :..|||:.|.:|..||..|||.|..|:||||||..|
Frog   497 RADTTQPSARMRGVGEGKRSALENTSNE-EPQGPSVLLHSGVYLSTAGLPPGHARDALEKALQSQ 560

Human   697 ES---------------------ERRKKLRFHPRQLYLSVKQGELQKVILMLLDNLDPNFQSDQQ 740
            |:                     :||||:|::.|||||||||||||||:|||:||.|.||.:|||
Frog   561 ETDSLLQGRNCHSLTESLLQQKRDRRKKIRYNSRQLYLSVKQGELQKVLLMLMDNQDSNFLNDQQ 625

Human   741 SKRTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKE 805
            .||:|||||||:||:|:||:|:||||:||:.||..||||:|||||||:::|:|:||.|.|||.||
Frog   626 LKRSPLHAAAQRGSLELCHILVQAGASINSTDKVLRTPLLEAVVNNHIDIAKYLVQCGACVYHKE 690

Human   806 EDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTL 870
            ||||||||||||.||||::..|||||||:|||||:|||||||||||||||:|||.||||||||||
Frog   691 EDGSTCLHHAAKSGNLELLCFLLSTGQVNVNAQDNGGWTPIIWAAEHKHIDVIRTLLTRGADVTL 755

Human   871 TDNVSERLVEEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFL 935
            .||       |:|||||||||||||.||||||||:|||||||:|||||||||:||.:..||.|||
Frog   756 QDN-------EKNICLHWASFTGSAEIAEVLLNAQCDLHAVNFHGDTPLHIASREGFIQCVNLFL 813

Human   936 SRGANPELRNKEGDTAWDLTPERSDVWFALQLNRKLRLGVGNRAIRTEKIICRDVARGYENVPIP 1000
            ||||:.|:||.||||..|||.|.:|||:|||||||:|.|:.|||:|||:||.||:|.|||.||||
Frog   814 SRGADTEIRNNEGDTPCDLTLEHTDVWYALQLNRKIRQGINNRAVRTERIISRDIAHGYERVPIP 878

Human  1001 CVNGVDGEPCPEDYKYISENCETSTMNIDRNITHLQHCTCVDDCSSSNCLCGQLSIRCWYDKDGR 1065
            ||||||.|.||:||||:|||||||.|:|||||||||:|:||||||||||||||||||||||||||
Frog   879 CVNGVDEELCPDDYKYVSENCETSAMSIDRNITHLQNCSCVDDCSSSNCLCGQLSIRCWYDKDGR 943

Human  1066 LLQEFNKIEPPLIFECNQACSCWRNCKNRVVQSGIKVRLQLYRTAKMGWGVRALQTIPQGTFICE 1130
            |||||||||||||||||||||||:.||||||||||||||||||||||||||||||.|||||||||
Frog   944 LLQEFNKIEPPLIFECNQACSCWQTCKNRVVQSGIKVRLQLYRTAKMGWGVRALQAIPQGTFICE 1008

Human  1131 YVGELISDAEADVREDDSYLFDLDNKDGEVYCIDARYYGNISRFINHLCDPNIIPVRVFMLHQDL 1195
            ||||||||||||||||||||||||||||||||||||||||:||||||||:||:|||||||.||||
Frog  1009 YVGELISDAEADVREDDSYLFDLDNKDGEVYCIDARYYGNVSRFINHLCEPNLIPVRVFMSHQDL 1073

Human  1196 RFPRIAFFSSRDIRTGEELGFDYGDRFWDIKSKYFTCQCGSEKCKHSAEAIALEQSRLARLDPHP 1260
            |||||||||.||||.|||||||||||||||||||||||||||:||||||||||||||||||:. |
Frog  1074 RFPRIAFFSGRDIRAGEELGFDYGDRFWDIKSKYFTCQCGSERCKHSAEAIALEQSRLARLEV-P 1137

Human  1261 ELLPELGSLP 1270
            :.:....|.|
Frog  1138 DAMSVSASTP 1147

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
EHMT2	XP_006715037.1	cond_enzymes	<46..>139	CDD:299129	15/73 (21%)
		Ank_2	711..798	CDD:289560	62/86 (72%)
		ANK	<711..762	CDD:295348	38/50 (76%)
		ANK	743..862	CDD:238125	89/118 (75%)
		ANK repeat	743..772	CDD:293786	20/28 (71%)
		Ank_2	779..872	CDD:289560	74/92 (80%)
		ANK	806..935	CDD:238125	101/128 (79%)
		ANK repeat	807..839	CDD:293786	25/31 (81%)
		ANK repeat	841..872	CDD:293786	28/30 (93%)
		ANK repeat	881..912	CDD:293786	27/30 (90%)
		Ank_5	901..954	CDD:290568	38/52 (73%)
		ANK repeat	914..945	CDD:293786	21/30 (70%)
		PreSET	987..1086	CDD:128744	86/98 (88%)
		SET	1102..1224	CDD:214614	114/121 (94%)
ehmt2	XP_004917185.1	ANKYR	603..791	CDD:223738	147/194 (76%)
		ANK repeat	628..657	CDD:293786	20/28 (71%)
		ANK repeat	659..690	CDD:293786	19/30 (63%)
		Ank_2	664..757	CDD:372319	74/92 (80%)
		ANK repeat	692..724	CDD:293786	25/31 (81%)
		ANK repeat	727..757	CDD:293786	27/29 (93%)
		ANK repeat	759..790	CDD:293786	27/30 (90%)
		Ank_2	764..>829	CDD:372319	51/64 (80%)
		ANK repeat	792..823	CDD:293786	21/30 (70%)
		SET_EHMT2	890..1128	CDD:380931	221/237 (93%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	519	1.000	Domainoid score	I3433
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H48460
Inparanoid	1	1.050	1485	1.000	Inparanoid score	I1433
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG42320
OrthoDB	1	1.010	-	-		D48360at32523
OrthoFinder	1	1.000	-	-		FOG0003434
OrthoInspector	1	1.000	-	-		oto153146
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1720
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	10.980