Protein Alignment PAPOLA and hrg

DIOPT Version :10

• Sequence 1: NP_116021.2
• Gene: PAPOLA / 10914
• HGNCID: 14981
• Length: 745
• Species: Homo sapiens
• Sequence 2: NP_001261097.1
• Gene: hrg / 49636
• FlyBaseID: FBgn0015949
• Length: 827
• Species: Drosophila melanogaster
• Alignment Length: 839
• Identity: 382/839 - (45%)
• Similarity: 491/839 - (58%)
• Gaps: 140/839 - (16%)

Human     6 TTQGSQQTQPPQKHYGITSPISLAAPKETDCVLTQKLIETLKPFGVFEEEEELQRRILILGKLNN 70
            :|.|.    ||.|..|:||.||||.|:..|...|.:|..:|:|:.|||.::||..|:.||.|||.
  Fly    18 STSGG----PPAKQLGMTSAISLAEPRPEDLQRTDELRGSLEPYNVFESQDELNHRMEILAKLNT 78

Human    71 LVKEWIREISESKNLPQSVIENVGGKIFTFGSYRLGVHTKGADIDALCVAPRHVDRSDFFTSFYD 135
            |||:|::|||.|||:|:|..|.:||||:||||||||||.|||||||||||||:::|:|:|.||::
  Fly    79 LVKQWVKEISVSKNMPESAAEKLGGKIYTFGSYRLGVHHKGADIDALCVAPRNIERTDYFQSFFE 143

Human   136 KLKLQEEVKDLRAVEEAFVPVIKLCFDGIEIDILFARLALQTIPEDLDLRDDSLLKNLDIRCIRS 200
            .||.|.||.:.|:||||||||||:.|||||||:|||||:|:.||:|.|||||:||:|||.|.:||
  Fly   144 VLKKQPEVTECRSVEEAFVPVIKMNFDGIEIDLLFARLSLKEIPDDFDLRDDNLLRNLDHRSVRS 208

Human   201 LNGCRVTDEILHLVPNIDNFRLTLRAIKLWAKRHNIYSNILGFLGGVSWAMLVARTCQLYPNAIA 265
            |||||||||||.|||||:||||.||.||||||:|.||||.||:.|||:|||||||||||||||.|
  Fly   209 LNGCRVTDEILALVPNIENFRLALRTIKLWAKKHGIYSNSLGYFGGVTWAMLVARTCQLYPNAAA 273

Human   266 STLVHKFFLVFSKWEWPNPVLLKQPEECNLNLPVWDPRVNPSDRYHLMPIITPAYPQQNSTYNVS 330
            :|||||||||||:|:||||||||.|:..||...|||||||.||||||||||||||||||||:|||
  Fly   274 ATLVHKFFLVFSRWKWPNPVLLKHPDNVNLRFQVWDPRVNASDRYHLMPIITPAYPQQNSTFNVS 338

Human   331 VSTRMVMVEEFKQGLAITDEILLSKAEWSKLFEAPNFFQKYKHYIVLLASAPTEKQRLEWVGLVE 395
            .||:.|::.||.:|:.|||||:|.:..|.:|||||:||.:|:|:||||.::.|....|||.||||
  Fly   339 ESTKKVILTEFNRGMNITDEIMLGRIPWERLFEAPSFFYRYRHFIVLLVNSQTADDHLEWCGLVE 403

Human   396 SKIRILVGSLEKNEFITLAHVNPQSFPAPK--------ENPDKEE----------------FRTM 436
            ||:|:|:|:||:|..|.||||||:.|...|        .|...|:                |.:|
  Fly   404 SKVRLLIGNLERNPHIALAHVNPKCFEFKKGQSANNSQNNSGNEDDLKQSQGNQSAVTSAPFCSM 468

Human   437 WVIGLVFKKTENSENLSVDLTYDIQSFTDTVYRQAINSKMFEVDMKIAAMHVKRKQL-------- 493
            |.|||.|   |.||||:||||..||:||:.|....:|.||.:..|.|.|.|||||||
  Fly   469 WFIGLEF---ERSENLNVDLTESIQNFTEHVMMHGVNIKMLKEGMTIDARHVKRKQLSLYLDSDF 530

Human   494 ----------HQLLPNHVLQKKKKHSTE-----------------------GVKLTALNDSSLDL 525
                      |....|.:|..:|:.|||                       |.|:..|:||..:.
  Fly   531 LKRERKSMESHNNFNNTLLANRKRLSTELAQSQDPLPPGQQPSSGNRGRDSGAKIQRLSDSLTEE 595

Human   526 SMDSDNSMSVPSPTSATKTSPLNSSGSSQGRNSPAPAVTAASVTNIQATEVSVPQVNSSESSGGT 590
            :.::.:.|...:||:.|.......|..|.|:|        .|..::...|.:.|..|.:.||..|
  Fly   596 NSNASSDMGAGTPTTPTTAQLSAPSFKSSGKN--------GSEIDVVEQEPTQPHNNGNASSNTT 652

Human   591 SSE----SIPQTA------TQPAISPPPKP-------------TVSRVVSSTRLVNPPPRSSGNA 632
            ::|     .|.|.      .||..:||..|             ..:...:|..:.|  .||..:|
  Fly   653 TTEVACSXQPPTLHPHPPHQQPPPAPPQPPAHHHHHQKFRKNNNAAAAAASNSIFN--QRSILHA 715

Human   633 ATSGNAATKIPTPIVGVKRTSSPHKEESPKKTKTEEDETSEDANCLALSGH-------------- 683
            |:|.:||..    |.|.||     |:::...|..........:|....|.|
  Fly   716 ASSLSAALS----ITGHKR-----KQQTATSTTMISSSNIAHSNYTQHSTHNNNGGGGGSHYNKT 771

Human   684 -----DKTEAKEQLDTETSTTQSETIQTAASLLASQKTSSTDLSDIP--ALPANPIPVI 735
                 |..:..:.|.|..:.||.:  |.|..:.|   ||::..:.:|  |..|.|.|.|
  Fly   772 YYIDDDDEDNNQPLLTPNNQTQQQ--QKAVRITA---TSASPATSVPVAASAAPPAPTI 825

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PAPOLA	NP_116021.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..22		5/15 (33%)
		PAP_central	21..363	CDD:461486	235/341 (69%)
		PAP_RNA-bind	367..495	CDD:461484	69/169 (41%)
		Nuclear localization signal 1. /evidence=ECO:0000250	490..507		7/34 (21%)
		motB	<501..646	CDD:183756	42/190 (22%)
		Ser/Thr-rich	508..643		40/180 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	523..565		8/41 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	577..704		36/168 (21%)
		Nuclear localization signal 2. /evidence=ECO:0000250	650..665		3/14 (21%)
		Required for interaction with NUDT21	677..745		18/80 (23%)
hrg	NP_001261097.1	PAP_central	29..371	CDD:461486	235/341 (69%)
		PAP_RNA-bind	374..534	CDD:461484	69/162 (43%)