DRSC/TRiP Functional Genomics Resources

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Protein Alignment PNPLA6 and NTE1

DIOPT Version :9

Sequence 1:NP_001159583.1 Gene:PNPLA6 / 10908 HGNCID:16268 Length:1375 Species:Homo sapiens
Sequence 2:NP_013652.1 Gene:NTE1 / 854943 SGDID:S000004524 Length:1679 Species:Saccharomyces cerevisiae


Alignment Length:1517 Identity:391/1517 - (25%)
Similarity:621/1517 - (40%) Gaps:449/1517 - (29%)


- Green bases have known domain annotations that are detailed below.


Human   159 QRKEPPPAV-------------LEADLTEGDLANSHLPSEVLYMLKNVRVLGHFEKPLFLELCRH 210
            |....|||:             .:..|.:|:...:.|.|.:...|..:::.|:.|||:|.:|.::
Yeast   160 QSANAPPAIGSSTTGASSIIDSKKHSLKDGNENETFLSSYLDQFLSAIKIFGYLEKPVFHDLTKN 224

Human   211 MVFQRLGQGDYVFRPGQPDASI--YVVQDGLLELC------------------------------ 243
            |..|::.:|:.:..    |::|  .:|.:|.|:|.                              
Yeast   225 MKTQKMDEGEILLL----DSTIGFAIVVEGTLQLYHEVDHSDKDHGDETDHSDTDGLDDQDRDEE 285

Human   244 -------LPGPDGKEC-------------------------VVKEVVPGDSVNSLLSILDVIT-- 274
                   :...|.|.|                         ::..|.||:.:.||:|||::.|  
Yeast   286 DEEEDDDIDNYDTKSCSSNLIDEEDESVGYIHLKNGLGNFQLLNTVKPGNPLTSLVSILNLFTHS 350

Human   275 ----GHQH-PQR-------TVS------------------------------------ARAARDS 291
                |:.: |..       |||                                    ||||.|.
Yeast   351 MSSYGNSNFPSELSSPIDTTVSVNNMFCSSEQNFSNTDSMTNSTNSFPTFPSSMPKLVARAATDC 415

Human   292 TVLRLPVEAFSAVFTKYPESLVRVVQIIMVRLQRVTFLALHNYLGLTNELFSHEI---------- 346
            |:..:|.::|:.:..|||.|...::|:::.:|..|||...|:|||||.|:...|:          
Yeast   416 TIGIIPPQSFAKLTAKYPRSASHIIQMVLTKLYHVTFQTAHDYLGLTKEIMDIEVLLNKSIVYEL 480

Human   347 --------------------------------------QPLRLFPSPGL---------------- 357
                                                  :|.:..||.|:                
Yeast   481 PYYLKEAVIRKFKTVDKSSGSADLEPKPKNSNASSKLKKPPKAKPSDGIIQSLKIANANANTSSN 545

Human   358 -----------PTRTSPVRGSK------------------------------------------- 368
                       |:....|.||:                                           
Yeast   546 SLSLKPEFTHHPSSRHVVLGSRDQFNPGDLLSNVPLSRTMDILSPNPIHNNNRNKSNGINTSTSN 610

Human   369 ------RMVSTSATDEPRETPGRPPDPTGAPLPGPTGDPVKPTSLETPS-------APLLSRCVS 420
                  |..|.:|:...::.....|:...|.|      ...|.||:..|       :|     |.
Yeast   611 QHKRSSRSSSNNASVHSKKFSSLSPELRNAQL------STSPLSLDNTSVHDHIHPSP-----VH 664

Human   421 MPGDISGLQGGPR------SDFDMAYE----------------------RGRISVSLQEEASGGS 457
            :.|.:|     ||      :.|..|.|                      :..:|||....|:..|
Yeast   665 LKGRVS-----PRPNLLPTTSFSAAQEETEDSALRMALVEAMLTYLGVNKSNMSVSSSSIANMSS 724

Human   458 LAAPARTPTQEPREQPAGACEYSYCEDESATGGCPFGPYQGRQTSSIF----------------- 505
            |.:|........|...|......:|.....:....|...|.:.|....                 
Yeast   725 LNSPQLNEMYSRRPSNASFLMSPHCTPSDISVASSFASPQTQPTMLRILPKEYTISNKRHNKSKS 789

Human   506 ------EAAKQELAKLMRIEDPSL-LNSRVLLHHAKAGTIIARQGDQDVSLHFVLWGCLHVYQR- 562
                  .|.|:||...:..||... ....:.|...|.||.|..|..:...|.:::.|.::|... 
Yeast   790 QDKKKPRAYKEELTPNLDFEDVKKDFAQGIQLKFFKKGTTIVEQNARGKGLFYIISGKVNVTTNS 854

Human   563 ------MIDKAEDV----------------CLFVAQPGELVGQLAVLTGEPLIFTLRAQRDCTFL 605
                  .:.|.|.|                .|:....|.:||.|:.|.|......:.|:.|....
Yeast   855 SSSVVSSMSKPEQVSAQSSHKGENPHHTQHLLYSVGSGGIVGYLSSLIGYKSFVNIVAKSDVYVG 919

Human   606 RISKSDFYEIMRAQPSVVLSAAHTVAARMSPFVRQMDFAIDWTAVEAGRALYRQGDRSDCTYIVL 670
            .:|.:....:......:.|..:.::...:|..:.::|.|::|..:.|...|:.|||.::..|:||
Yeast   920 FLSSATLERLFDKYFLIYLRISDSLTKLLSSRLLKLDHALEWVHLRASETLFSQGDSANGIYVVL 984

Human   671 NGRLRSVIQRGSGKKE-----------LVGEYGRGDLIGVVEALTRQPRATTVHAVRDTELAKLP 724
            |||||.:.|:......           ::||..:|:..|.||.||...|.:|:.||||:|||::|
Yeast   985 NGRLRQLQQQSLSNSNTSSEEVETQNIILGELAQGESFGEVEVLTAMNRYSTIVAVRDSELARIP 1049

Human   725 EGTLGHIKRRYPQVVTRLIHLLSQKILGNLQQLQGPFPAGSGLG---------VPP-----HSEL 775
            ......:...:|.::.|:..|:::||:|:...   |...|..|.         :||     .|.|
Yeast  1050 RTLFELLALEHPSIMIRVSRLVAKKIVGDRTV---PALTGDPLSIKENDFTSLIPPTKASYSSSL 1111

Human   776 TNPASNLA-------TVAILPVCAEVPMVAFTLELQHALQAIGPTLL-LNSDIIRARLGASALDS 832
            ::...|:.       |:.|||:.:.:|:.||.::|..|.:.:|.|.: ||.......||..|.|.
Yeast  1112 SHKPQNITSGTITFRTITILPITSGLPVEAFAMKLVQAFKQVGRTTIGLNQRTTLTHLGRHAFDR 1176

Human   833 IQEFRLSGWLAQQEDAHRIVLYQTDASLTP----WTVRCLRQADCILIVGLGD-QEPT--LGQLE 890
            :.:.:.||:.|:.|:.::.|:|.:|   ||    ||..|:.|.||||:  |.| :.|:  :|:.|
Yeast  1177 LSKLKQSGYFAELEEMYQTVVYISD---TPVKSNWTRTCIAQGDCILL--LADARSPSAEIGEYE 1236

Human   891 QMLENTAVRALKQLVLLHREEGAGPTRTVEWLNMRSWCSGHLHLRCPRRLFSRRSPAKLH----- 950
            ::|.|:...|..:|:|||.|....|..|.:||..|.|...|.|::......:..:..|:|     
Yeast  1237 KLLLNSKTTARTELILLHPERYVEPGLTHKWLRYRPWVHSHHHIQFSLTGTTLMNEGKMHVLNNG 1301

Human   951 ------ELYEKVFSRRAD----------------------------------RH-SDFSRLARVL 974
                  :|.:..|||:..                                  || :||.||||:|
Yeast  1302 ALALMDKLIQTEFSRKTQQNISKLLPDSIKNTVENFSSRFMKSKRQYYTPVHRHKNDFLRLARIL 1366

Human   975 TGNTIALVLGGGGARGCSHIGVLKALEEAGVPVDLVGGTSIGSFIGALYAEERSASRTKQRAREW 1039
            :|..|.||||||||||.||:||::|:||.|:|||::||||||||:|.|||::........|.:::
Yeast  1367 SGQAIGLVLGGGGARGISHLGVIQAIEEQGIPVDVIGGTSIGSFVGGLYAKDYDLVPIYGRVKKF 1431

Human  1040 AKSMTSVLEPVLDLTYPVTSMFTGSAFNRSIHRVFQDKQIEDLWLPYFNVTTDITASAMRVHKDG 1104
            |..::|:...:.|||:||||..||..|||.|.:.|.|.:|||.|:.|:..:|:||.|...:|..|
Yeast  1432 AGRISSIWRMLTDLTWPVTSYTTGHEFNRGIWKTFGDTRIEDFWIQYYCNSTNITDSVQEIHSFG 1496

Human  1105 SLWRYVRASMTLSGYLPPLCDPKDGHLLMDGGYINNLPADIARSMGAKTVIAIDVGSQDETDLST 1169
            ..|||:||||:|:|.||||  .::|.:|:||||::|||....|:.|.:|:.|:||||.|:.....
Yeast  1497 YAWRYIRASMSLAGLLPPL--EENGSMLLDGGYVDNLPVTEMRARGCQTIFAVDVGSADDRTPME 1559

Human  1170 YGDSLSGWWLLWKRLNPWADKVKVPDMAEIQSRLAYVSCVRQLEVVKSSSYCEYLRPPIDCFKTM 1234
            |||||:|:|:::.|.||::....:|:|||||.||.||:.|..||..|::....|:||||:.:.|:
Yeast  1560 YGDSLNGFWIIFNRWNPFSSHPNIPNMAEIQVRLGYVASVNALEKAKNTPGVVYVRPPIEEYATL 1624

Human  1235 DFGKFDQIYDVGYQYGKAVFGG 1256
            ||.||::||.||..||:....|
Yeast  1625 DFSKFEEIYHVGVDYGRIFLQG 1646

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PNPLA6NP_001159583.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..20
CAP_ED 195..316 CDD:237999 44/234 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 352..436 23/172 (13%)
Atrophin-1 <354..502 CDD:331285 37/258 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 449..472 5/22 (23%)
CAP_ED 512..622 CDD:237999 25/133 (19%)
CAP_ED 635..743 CDD:237999 38/118 (32%)
Pat_PNPLA6_PNPLA7 964..1269 CDD:132864 144/294 (49%)
GXGXXG. /evidence=ECO:0000255|PROSITE-ProRule:PRU01161 985..990 4/4 (100%)
GXSXG. /evidence=ECO:0000255|PROSITE-ProRule:PRU01161 1012..1016 3/3 (100%)
DGA/G. /evidence=ECO:0000255|PROSITE-ProRule:PRU01161 1134..1136 1/1 (100%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1306..1375
NTE1NP_013652.1 cNMP_binding 821..933 CDD:394984 22/111 (20%)
CAP_ED 957..1067 CDD:237999 35/109 (32%)
Pat_Fungal_NTE1 1361..1629 CDD:132865 132/269 (49%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C159050950
Domainoid 1 1.000 178 1.000 Domainoid score I810
eggNOG 1 0.900 - - E1_COG0664
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 533 1.000 Inparanoid score I206
Isobase 1 0.950 - 0 Normalized mean entropy S2337
OMA 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0001797
OrthoInspector 1 1.000 - - otm52875
orthoMCL 1 0.900 - - OOG6_101855
Panther 1 1.100 - - O PTHR14226
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X1325
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
1312.700

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