Protein Alignment PNPLA6 and nte1

DIOPT Version :10

• Sequence 1: NP_001159583.1
• Gene: PNPLA6 / 10908
• HGNCID: 16268
• Length: 1375
• Species: Homo sapiens
• Sequence 2: NP_588086.1
• Gene: nte1 / 2539411
• PomBaseID: SPCC4B3.04C
• Length: 1316
• Species: Schizosaccharomyces pombe
• Alignment Length: 1384
• Identity: 403/1384 - (29%)
• Similarity: 624/1384 - (45%)
• Gaps: 306/1384 - (22%)

Human   103 KVLFYGRKIMRKVSQSTSSLVDTSV-----SATSRPRMRKKLKMLNIA----------------- 145
            ||:|:   ::|.|:.|..|:...|:     :..:.|:...|:...::.
pombe    15 KVIFF---VLRSVTLSLVSVTRFSLFLLSFATITVPKWAYKIVTYSLTIQFNFKSLLFLFFVSIC 76

Human   146 -----------KKILRIQKETPTLQRKEPPPAVLEADLTEGDLANSHLPSEVLYMLKN------- 192
                       .|..|:..|.|..:.|..|...:.             |||.....:|
pombe    77 VVILVVRYRYLNKYARLPHEAPIKEAKLGPDTNIR-------------PSEPRIGFQNYLDEFLS 128

Human   193 -VRVLGHFEKPLFLELCRHMVFQRLGQGDYVFRPGQPDASIYVVQDGLLEL-CLPGPDGKECV-- 253
             :.:.|:.|||:|:||.||:..||:.:|:.::...|  :|..:|.||..:: ..|..|..|.|
pombe   129 AISIFGYLEKPVFVELARHIRTQRVAEGNTIYLGEQ--SSFILVVDGCFQVFTAPEKDSAEVVEE 191

Human   254 --------VKEVVPGDSVNSLLSILDVI-------TGHQHPQRT--------------------- 282
                    :.||..|..::|..::|::.       |..::|.::
pombe   192 AGQPEYRLLTEVSNGAPLSSFFTVLELFTELIPEATSKENPFKSTTSSLRPGSSTTTEAGANNAS 256

Human   283 -----------VSARAARDSTVLRLPVEAFSAVFTKYPESLVRVVQIIMVRLQRVTFLALHNYLG 336
                       :.|:|..|:|:..:|..||..:..|:|.|..::||:|:.|.|||||...:.|||
pombe   257 KPHMPQPKKARIIAKAKIDTTIAVIPANAFHHLVHKFPNSSAQIVQVILTRFQRVTFSTGYEYLG 321

Human   337 LTNELFSHE--IQPLRLFPSPG-----------------------------LPTRTSPVRGSKRM 370
            |::.:||.|  ...|..:..|.                             |.::.:..|.|.:.
pombe   322 LSDAIFSIEKNFNSLTAYELPNYIRSDIIDDFKKEAMSEHLSQASNESFIVLRSKGAQSRLSNQY 386

Human   371 VSTS--------ATDEPRETPGRPPDPTGAPLPGPTGDPVKPTSLETPSAPLLSRCVSMPGDISG 427
            .|.:        .:|..|.|..             .||.:..|:   |.:.|||..|
pombe   387 FSKAFDKEHGNFVSDIDRSTAN-------------AGDLLSSTN---PHSTLLSTSV-------- 427

Human   428 LQGGPRSDFDM--AYERGRISVSLQEEASGGSLAAPARTPTQEPREQPAGACEYSYCEDE----- 485
               ||...|.:  :|.|         |.....::|..|....:...:..|...|...||.
pombe   428 ---GPLRKFPLNRSYSR---------EVGDYDISASFRDGLLQCIFKSLGVFNYELKEDNDDLCT 480

Human   486 ------------------------SATGGCPFGPYQGRQTSSIFEAAKQ----ELAKLMRIEDPS 522
                                    |||.       :....|||..:.|:    |.||  .||
pombe   481 ENDSSEGDSDSLKKVDFLGQIAMMSATD-------REEVKSSIVVSTKKSTILEFAK--EIE--- 533

Human   523 LLNSRVLLHHAKAGTIIARQGDQDVSLHFVLWGCLH-------VYQRMIDKAEDVCLFVAQPGEL 580
                 ::.:  |.||.|.||||....|::::.|.|.       .:....|....:..|:.:||.:
pombe   534 -----IIFY--KKGTTIVRQGDHADGLYYIIDGFLDATCPSKLTFSTSYDTDLGMHSFMIKPGGI 591

Human   581 VGQLAVLTGEPLIFTLRAQRDCTFLRISKSDFYEIMRAQPSVVLSAAHTVAARMSPFVRQMDFAI 645
            |...|.::.......:.|:.|.....:.:|....|:..:|.:.|:.|..:.:.:...:.::|||:
pombe   592 VNYQACVSNYRSFINVTARSDVLVGFLPRSCLERIIDQEPLISLTIAKRLISLVPSLLLKLDFAV 656

Human   646 DWTAVEAGRALYRQGDRSDCTYIVLNGRLRSV-IQRGSGKKEL--VGEYGRGDLIGVVEALTRQP 707
            .|..:...:.:|.:.|.|||.|:||||||||: .:|||.:.::  ..|||:||.:|.:|.|....
pombe   657 GWIHLNPDQVVYEKNDPSDCVYVVLNGRLRSIEDERGSARTQVDYFNEYGKGDSVGELEMLLNNR 721

Human   708 RATTVHAVRDTELAKLPEGTLGHIKRRYPQVVTRLIHLLSQKILGNLQQLQGPFPAGSGLGVPPH 772
            |::|:.|:||:||||:||.....:...:|.|..:|     .||:.|...|.....:..|:...||
pombe   722 RSSTLFAIRDSELAKIPETLFNALSLSHPAVGLQL-----SKIIANRMNLLLNNKSMDGMQHQPH 781

Human   773 SELTNPASNLATVAILPVCAEVPMVAFTLELQHALQAIGPTL-LLNSDIIRARLGASALDSIQEF 836
            .:     .::.|:||:|..:...::.|:.:|...|..:|.:: :|....:...||..|...:..|
pombe   782 EK-----HSIRTLAIVPSSSTGLLILFSQKLTSVLSVMGKSVKVLRQSSVLEHLGKHAFSRMGRF 841

Human   837 RLSGWLAQQEDAHRIVLYQTDASL-TPWTVRCLRQADCILIVGLGDQEPTLGQLEQMLENTAVRA 900
            :||.:|:..||.:.|::|..|:.: :.|...|:||||||.|:...||.|.:|:.||.|......|
pombe   842 KLSSYLSDLEDKYDILIYVADSGVGSAWLQTCIRQADCIYILAEADQNPNIGEYEQHLIAMKSTA 906

Human   901 LKQLVLLHREE--GAGPTRTVEWLNMRSWCSGHLHLRCPRRL---FSRRSPAK------------ 948
            .|:|||||.|.  .:|.||.  ||..|.|...|.|::....|   .|:.:.||
pombe   907 RKELVLLHPERFCPSGLTRL--WLKERPWVYAHHHVQLRIGLDNEISQNNEAKVFLNIIRAKVQN 969

Human   949 -------------LHELYEKVFSRRADRHSDFSRLARVLTGNTIALVLGGGGARGCSHIGVLKAL 1000
                         ||.:|:   :.|| :.|||:||||.:.|..||||||||||||.|.||:|.||
pombe   970 LHYGFRKYIDWKHLHPVYQ---ANRA-QDSDFARLARRICGKAIALVLGGGGARGISQIGILYAL 1030

Human  1001 EEAGVPVDLVGGTSIGSFIGALYAEERSASRTKQRAREWAKSMTSVLEPVLDLTYPVTSMFTGSA 1065
            ||||:|.|::||||||:|.|.|||.|........||:::...|.::...|||:|||..:..||..
pombe  1031 EEAGIPFDIIGGTSIGAFNGGLYAWEADLVPMFGRAKKFCGRMANLWRFVLDVTYPQAAYTTGHE 1095

Human  1066 FNRSIHRVFQDKQIEDLWLPYFNVTTDITASAMRVHKDGSLWRYVRASMTLSGYLPPLCDPKDGH 1130
            |||.|.:.|.:..|||.|||::..||:||.|.|.:|..|..|||:||||:|:|.:||:.. ..|.
pombe  1096 FNRGIWKTFGEIHIEDFWLPFYANTTNITHSRMDIHSSGYAWRYIRASMSLAGLVPPMLS-DSGD 1159

Human  1131 LLMDGGYINNLPADIARSMGAKTVIAIDVGSQDETDLSTYGDSLSGWWLLWKRLNPWADKVKVPD 1195
            :|:||||::||.....:|:||.::.||||||:|..:...|||::||.|.|..|..|:..|...|.
pombe  1160 MLLDGGYMDNLTVSHMQSLGASSIFAIDVGSEDSREPMHYGDTVSGVWALISRWIPFIPKTSFPS 1224

Human  1196 MAEIQSRLAYVSCVRQLEVVKSSSYCEYLRPPIDCFKTMDFGKFDQIYDVGYQYGKAVFGGWSRG 1260
            :|||||||.||:.|...|.|||...|.|:|||:..|.|::||.|::||:|||.|||
pombe  1225 LAEIQSRLTYVTSVATGEKVKSMPGCFYMRPPVKDFPTLEFGSFEKIYNVGYNYGK--------- 1280

Human  1261 NVIEKMLTDRRSTDLNESR 1279
            ..:||:.|..:..|:...|
pombe  1281 EYVEKLKTSHKLDDILSPR 1299

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PNPLA6	NP_001159583.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..20
		CAP_ED	195..316	CDD:237999	38/170 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	352..436		18/120 (15%)
		PHA03247	<354..502	CDD:223021	31/215 (14%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	449..472		3/22 (14%)
		CAP_ED	512..622	CDD:237999	26/116 (22%)
		CAP_ED	635..743	CDD:237999	42/110 (38%)
		Pat_PNPLA6_PNPLA7	964..1269	CDD:132864	148/304 (49%)
		GXGXXG. /evidence=ECO:0000255|PROSITE-ProRule:PRU01161	985..990		4/4 (100%)
		GXSXG. /evidence=ECO:0000255|PROSITE-ProRule:PRU01161	1012..1016		3/3 (100%)
		DGA/G. /evidence=ECO:0000255|PROSITE-ProRule:PRU01161	1134..1136		1/1 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1306..1375
nte1	NP_588086.1	CAP_ED	522..638	CDD:237999	28/127 (22%)
		CAP_ED	641..756	CDD:237999	42/114 (37%)
		Pat_Fungal_NTE1	999..1268	CDD:132865	134/269 (50%)