Protein Alignment PNPLA6 and pnpla6

DIOPT Version :10

• Sequence 1: NP_001159583.1
• Gene: PNPLA6 / 10908
• HGNCID: 16268
• Length: 1375
• Species: Homo sapiens
• Sequence 2: XP_031755196.1
• Gene: pnpla6 / 100489110
• XenbaseID: XB-GENE-959403
• Length: 1225
• Species: Xenopus tropicalis
• Alignment Length: 1352
• Identity: 662/1352 - (48%)
• Similarity: 849/1352 - (62%)
• Gaps: 197/1352 - (14%)

Human    48 GAQPVPFVPQVLGVMIGAGVAVVVTAVLILLVVRRLR------VPKTPAPDGPRYRFRKRDKVLF 106
            ||....|:..:|.|.:.|...|.....::.|:.||..      :||..||..|:
 Frog    12 GAPNDTFMLHILEVGLLAMGGVCFLCFILWLLQRRTADPHVTDIPKLQAPKMPQ----------- 65

Human   107 YGRKIMRKVSQSTSSLVDTSVSATSRPRMRKKLKMLNIAKKILRIQKETPTLQRKEPPPAVLEAD 171
                                       :::||.|:|:|.::|.|.:.|:|::...||||..|...
 Frog    66 ---------------------------KLQKKPKVLSIRQRIRRRKWESPSVHHTEPPPVPLLKP 103

Human   172 LTEGDLANSHLPSEVLYMLKNVRVLGHFEKPLFLELCRHMVFQRLGQGDYVFRPGQPDASIYVVQ 236
            ..| .||.: ||.:|||||::||||||||:||||.||:|:|::.......||.|||||:|||:|.
 Frog   104 AAE-PLAPT-LPPDVLYMLQSVRVLGHFERPLFLALCQHVVYEHYDPDQIVFCPGQPDSSIYIVL 166

Human   237 DGLLELCLPGPDGKECVVKEVVPGDSVNSLLSILDVITGHQHPQRTVSARAARDSTVLRLPVEAF 301
            :|.|||.|..|||....:|.:..||:|:||||||||:||||.|.|||:|||...||:||||||||
 Frog   167 EGKLELSLTDPDGTSWNMKSICQGDNVHSLLSILDVLTGHQRPYRTVTARAVEKSTLLRLPVEAF 231

Human   302 SAVFTKYPESLVRVVQIIMVRLQRVTFLALHNYLGLTNELFSHEIQPLRLFPSPGLPTRTSPVRG 366
            ..:|..||:||||.||||.:|||||||||||:|||||.|||    ||.:  |.|
 Frog   232 CTIFKSYPQSLVRTVQIIALRLQRVTFLALHHYLGLTIELF----QPEK--PDP----------- 279

Human   367 SKRMVSTSATDEPRETPGRPPDPTGAPLPGPTGDPVKPTSLETPSAPLLSRCVSMPGDISGLQGG 431
                   :.|.:|:    ||     ..|...|.:.....:||..:.| ..|...:....|....|
 Frog   280 -------AQTQQPK----RP-----RLLRSVTHNEEDMCNLEEKNPP-RRRAPQLGSSKSARSSG 327

Human   432 PRSDFDMAYERGRISVSLQE----EASGGSLAAPARTPTQEPREQPAGACEYSYCEDESATGGCP 492
            .....|...|:.:...||.:    :.:..:...|..|.:::.||
 Frog   328 FWRSLDCELEQSQAFDSLHDNETSKPNSSTNTRPLVTESEKARE--------------------- 371

Human   493 FGPYQGRQTSSIFEAAKQELAKLMRIEDPSLLNSRVLLHHAKAGTIIARQGDQDVSLHFVLWGCL 557
                   :...:.|:.|:::|:|:.:::..||:.||.||||||.|:|||:|:|.|.:|.:|.|||
 Frog   372 -------ERMKLIESGKKQMAQLLNLKNVGLLDDRVTLHHAKADTVIARKGEQGVGMHLLLSGCL 429

Human   558 HVYQRMIDKAEDVCLFVAQPGELVGQLAVLTGEPLIFTLRAQRDCTFLRISKSDFYEIMRAQPSV 622
            ||||.:..: ||..:|...|||::|||.||||||||||:||.:|.|||.:|::.||:|:|:.|.|
 Frog   430 HVYQGVTGR-EDCYVFETGPGEMIGQLTVLTGEPLIFTIRAIQDSTFLCLSRAHFYQILRSHPHV 493

Human   623 VLSAAHTVAARMSPFVRQMDFAIDWTAVEAGRALYRQGDRSDCTYIVLNGRLRSVIQRGSGKKEL 687
            :|:.||:||.|:||||||:||||||..||||:.|||.||.||||||.||||||||||...|||.:
 Frog   494 LLTVAHSVARRVSPFVRQVDFAIDWMGVEAGKELYRMGDPSDCTYIALNGRLRSVIQHPDGKKCV 558

Human   688 VGEYGRGDLIGVVEALTRQPRATTVHAVRDTELAKLPEGTLGHIKRRYPQVVTRLIHLLSQKILG 752
            |||:|||:|||:|||||.:||||:||||||:||||:|:|.|.:||:|||||||||||.||||:||
 Frog   559 VGEHGRGELIGMVEALTHRPRATSVHAVRDSELAKVPDGALSYIKKRYPQVVTRLIHFLSQKVLG 623

Human   753 NLQQLQGPFPAGSGLGVPPHSELTNPASNLATVAILPVCAEVPMVAFTLELQHALQAIGPTLLLN 817
            |||:.||.:       :.|    .|.||||.||.:||..::||:.||||||:|||.||||||:|.
 Frog   624 NLQEPQGEY-------IDP----GNLASNLCTVCVLPCNSKVPLTAFTLELKHALNAIGPTLVLT 677

Human   818 SDIIRARLGASALDSIQEFRLSGWLAQQEDAHRIVLYQTDASLTPWTVRCLRQADCILIVGLGDQ 882
            ||||||||||.||:|..|.:||.|||||||.||||||||:..:|.|||||:|||||||:||||.:
 Frog   678 SDIIRARLGAHALESTHECQLSTWLAQQEDLHRIVLYQTEPLITSWTVRCIRQADCILVVGLGGE 742

Human   883 EPTLGQLEQMLENTAVRALKQLVLLHREEGAGPTRTVEWLNMRSWCSGHLHLRCPRRLFSRRSPA 947
            :|.||:||..||::.|||||||||||..||..|:.||||:|:|||.|||.|::.|||:|::|...
 Frog   743 DPALGELEIFLESSPVRALKQLVLLHHTEGPAPSGTVEWINLRSWVSGHFHIQTPRRVFTKRPLH 807

Human   948 KLHELYEKVFSRRADRHSDFSRLARVLTGNTIALVLGGGGARGCSHIGVLKALEEAGVPVDLVGG 1012
            |:||||.|||...||||||||||||.|||||||||||||||||.:|:||:|||||||:|||:|||
 Frog   808 KVHELYSKVFQTEADRHSDFSRLARALTGNTIALVLGGGGARGFAHVGVIKALEEAGIPVDMVGG 872

Human  1013 TSIGSFIGALYAEERSASRTKQRAREWAKSMTSVLEPVLDLTYP-------------VTSMFTGS 1064
            ||:|:.:|.:||||..|::||.|..:||.:..|:|.....|...             :||.....
 Frog   873 TSMGAVVGGVYAEELKAAQTKHRTSKWAMARLSMLHCKACLVKDRFRTCGCHISASVLTSALLQC 937

Human  1065 AFNRSIHRVFQDKQIEDLWLPYFNVTTDITASAMRVHKD------------GSLWRYVRASMTLS 1117
            .|...: |||          ||             .::|            |.||||||||.:.:
 Frog   938 EFTEKV-RVF----------PY-------------PYRDNHVPCCDPFPSTGCLWRYVRASASYT 978

Human  1118 GYLPPLCDPKDGHLLMDGGYINNLPADIARSMGAKTVIAIDVGSQDETDLSTYGDSLSGWWLLWK 1182
            .||||||||:|.|||:||.|:||||||:|.|:||:||:|:|||.||:.|...|||||||||||||
 Frog   979 PYLPPLCDPRDSHLLLDGCYVNNLPADVAHSLGARTVLAVDVGQQDKWDTWNYGDSLSGWWLLWK 1043

Human  1183 RLNPWADKVKVPDMAEIQSRLAYVSCVRQLEVVKSSSYCEYLRPPIDCFKTMDFGKFDQIYDVGY 1247
            |:||||:|||||||||:|.||:|||.|.|||:||.|.|||||.||:..|.|.||.:|.:||||||
 Frog  1044 RINPWAEKVKVPDMAELQCRLSYVSGVNQLELVKLSGYCEYLSPPVQRFSTTDFHRFQEIYDVGY 1108

Human  1248 QYGKAVFGGWSRGNVIEKMLTDRRSTDLNESRRADVLAFPSSGFTDLAEIVSRIEPPTS-YVSDG 1311
            .|||.:|..|.||:|:||||.||.:.:..:.:.......|  ||||||||||.|||.|| ::..
 Frog  1109 DYGKLIFTEWYRGDVVEKMLQDRSALEFYQQQEGVTSGVP--GFTDLAEIVSCIEPVTSRHLFP- 1170

Human  1312 CADGEESDCLTEYEEDAGPD---CSRDEGGSPEGASPSTASEMEEEKSILRQ 1360
                         ||..|.|   ..:|..||.:|    .|.|.:|||::..|
 Frog  1171 -------------EEQEGKDEITLGQDMDGSIDG----HACETDEEKTLRLQ 1205

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PNPLA6	NP_001159583.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..20
		CAP_ED	195..316	CDD:237999	73/120 (61%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	352..436		14/83 (17%)
		PHA03247	<354..502	CDD:223021	21/151 (14%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	449..472		4/26 (15%)
		CAP_ED	512..622	CDD:237999	59/109 (54%)
		CAP_ED	635..743	CDD:237999	81/107 (76%)
		Pat_PNPLA6_PNPLA7	964..1269	CDD:132864	181/329 (55%)
		GXGXXG. /evidence=ECO:0000255|PROSITE-ProRule:PRU01161	985..990		4/4 (100%)
		GXSXG. /evidence=ECO:0000255|PROSITE-ProRule:PRU01161	1012..1016		3/3 (100%)
		DGA/G. /evidence=ECO:0000255|PROSITE-ProRule:PRU01161	1134..1136		1/1 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1306..1375		15/59 (25%)
pnpla6	XP_031755196.1	CAP_ED	125..244	CDD:237999	71/118 (60%)
		CAP_ED	396..498	CDD:237999	58/102 (57%)
		CAP_ED	506..614	CDD:237999	81/107 (76%)
		Patatin_and_cPLA2	824..1130	CDD:416256	181/329 (55%)