DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DHRS4 and CG12171

DIOPT Version :9

Sequence 1:	NP_066284.2	Gene:	DHRS4 / 10901	HGNCID:	16985	Length:	278	Species:	Homo sapiens
Sequence 2:	NP_649563.1	Gene:	CG12171 / 40690	FlyBaseID:	FBgn0037354	Length:	257	Species:	Drosophila melanogaster

Alignment Length:	250	Identity:	84/250 - (33%)
Similarity:	135/250 - (54%)	Gaps:	13/250 - (5%)

- Green bases have known domain annotations that are detailed below.

Human    32 NKVALVTASTDGIGFAIARRLAQDGAHVVVSSRK----QQNVDQAVATLQGEGLSVTGTVCHVGK 92
            :||.:||.::.|||...:..||:.|..:.:..|.    .:..:|.||......|.|   ...:..
  Fly     6 DKVIIVTGASSGIGAGTSVLLAKLGGLLTIVGRNLDKLNETAEQIVAAGGAPALQV---AADINS 67

Human    93 AEDRERLVATAVKLHGGIDILVSNAAVNPFFGSIMDVTEEVWDKTLDINVKAPALMTKAVVPEME 157
            ..|.:.:|:..:..||.||:||:||.:.. .|||.:.:.|.:|:.::.||::...:|..|.||:.
  Fly    68 ESDVQGIVSATLAKHGRIDVLVNNAGILE-LGSIENTSLEQFDRVMNTNVRSLYQLTHLVTPELI 131

Human   158 KRGGGSVVIVSSIAAFSPSPGFSPYNVSKTALLGLTKTLAIELAPRNIRVNCLAPGLIKTSFSRM 222
            |. .|::|.|||:......||...|||||.|:...|:.:|:||||:.:|||.:.||:|.|...|.
  Fly   132 KT-KGNIVNVSSVNGIRSFPGVLAYNVSKAAVDQFTRCVALELAPKGVRVNSVNPGVIITELQRR 195

Human   223 LWMDKEKE----ESMKETLRIRRLGEPEDCAGIVSFLCSEDASYITGETVVVGGG 273
            ..:|:|..    |..|.|..:.|.||.::.|..::||.|::||:.||.::.|.||
  Fly   196 GGLDQEAYVKFLEHAKVTHALGRPGEVKEVAAAIAFLASDEASFSTGISLPVDGG 250

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DHRS4	NP_066284.2	CR_SDR_c	23..278	CDD:187641	83/249 (33%)
		fabG	30..273	CDD:235975	82/248 (33%)
		Microbody targeting signal	276..278
CG12171	NP_649563.1	fabG	2..251	CDD:235975	83/249 (33%)
CG12171	NP_649563.1	NADB_Rossmann	4..254	CDD:304358	83/249 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165140590
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0725
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000019
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.740