DRSC/TRiP Functional Genomics Resources

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Protein Alignment ADCY3 and Ac78C

DIOPT Version :9

Sequence 1:XP_011530791.1 Gene:ADCY3 / 109 HGNCID:234 Length:1186 Species:Homo sapiens
Sequence 2:NP_001262138.1 Gene:Ac78C / 40333 FlyBaseID:FBgn0024150 Length:1727 Species:Drosophila melanogaster


Alignment Length:1445 Identity:421/1445 - (29%)
Similarity:632/1445 - (43%) Gaps:361/1445 - (24%)


- Green bases have known domain annotations that are detailed below.


Human     6 GFSEPEYSAEYSAEYSVSLPSDPDRGVGRTHEISVRNSGS----CLCLPRFMRLTFVPESLENLY 66
            |.|..|:..| |.....|:|....|.: .....|...||:    .|| |.... :|...|||..|
  Fly   256 GNSNFEHDLE-SGNSLASIPGQSQRPL-NNEMYSAFKSGNVVKGILC-PSLTN-SFKQSSLERSY 316

Human    67 QTYFKRQRHETLLVLVVFAALFDCYVVVMCAVVF----------SSDKLASLAVAGIGLVLDIIL 121
            .||..|||.::|:::.|    .|..:.::.|.|:          .||...|:|.|       |..
  Fly   317 LTYTHRQRQKSLIIVNV----VDFVLKIVLAFVWIMRRSELGPIESDDGTSMATA-------ITW 370

Human   122 FVLCKKGLLPDRVTRRVLPY--------------VLWLLITAQIFSYLGLNFARAHAASDTVGWQ 172
            .|.|  |:....:.  .|.|              ..|:|...|.|...|:.|    |..:.:.|.
  Fly   371 SVCC--GIANMAIC--FLGYWRCFANNYLHWAAVCTWVLFNIQGFVGQGVGF----ADREYLVWY 427

Human   173 VFFV-FSFFITLPLSLSPIVIISVVSCVVHTLVLGVTVAQQQQEELKGMQLLREILANVFLYLCA 236
            :.|| |..:..|||.|...|:...::...|..|:.:...|..:..:....:|.:|.||..||...
  Fly   428 ILFVIFVPYAMLPLPLKWCVVGGTITASCHLAVITIIKLQHGEATINPECVLFQIFANFILYTAI 492

Human   237 IAVGIMSYYMADRKHRKAFLEARQSLEVKMNLEEQSQQQENLMLSILPKHVADEMLKDMKKDESQ 301
            ...|:.:.|:.||..|.||:|..:::|.|...|::.|:.:.|:.||||..|.:::..:|.|....
  Fly   493 NVAGMYTKYLTDRGQRLAFIETHKAMEHKKESEKELQRTQKLLDSILPNIVNNQIRSEMYKGTDP 557

Human   302 KDQQQFNTMYMYRHENVSILFADIVGFTQLSSACSAQELVKLLNELFARFDKLAAKYHQLRIKIL 366
            ..:.|||.:|:|..:|||||||||.|||:|:|..|||:|||:||:||||||::|...|.||:|:|
  Fly   558 TVETQFNKLYVYPMDNVSILFADIKGFTELASKTSAQQLVKILNDLFARFDRIAEDNHCLRVKLL 622

Human   367 GDCYYCICGLPD----YREDHAVCSILMGLAMVEAISYVREKTKTGVDMRVGVHTGTVLGGVLGQ 427
            ||||||:.....    .|.||||||:..||.|::||..||..|...::||:|:|:|:|:.||||.
  Fly   623 GDCYYCVSQFESDNWKTRPDHAVCSVETGLHMIKAIKDVRLHTHVDLNMRIGIHSGSVMCGVLGN 687

Human   428 KRWQYDVWSTDVTVANKMEAGGIPGGSKIEERLYSCVVAPTLRLRWERVHISQSTMDCLKGEFDV 492
            |:|.:||||.||.:||.||:|||||                      |||||::|:.||...::|
  Fly   688 KKWHFDVWSNDVIIANHMESGGIPG----------------------RVHISEATLKCLNDAYEV 730

Human   493 EPGDGGSRCDYLEEKGIETYLIIASKPEVKK----TATQNGLNGS--------ALPNGAPASSKS 545
            |||:||.|.::|:...::||||..::|...|    |.:...|.||        |.|...|.|..:
  Fly   731 EPGNGGCRDNHLKMLNVKTYLIKRTEPLRPKRRFGTRSSAHLAGSVATAAPPCATPTALPKSISA 795

Human   546 SSPALI--ETKEPNGSAHSSG------STSEKPEEQDAQLFP------TTLSHLPH--------S 588
            |....|  .|...|..|...|      :|...|.:|..||..      .:|:.||:        |
  Fly   796 SGSGSIGGVTATGNDGASIDGRSLEYAATIAVPAQQPTQLLQQQQKKNISLNSLPNVVEGVAMDS 860

Human   589 RCLPG---------------------SQADNP----SFP-----NPRR-RLRLQDLADRV----- 617
            |.:..                     |...:|    |.|     .||. ...:|:||:.:     
  Fly   861 RRIRNGCGVMGGAGGTGGGGTGPCGMSTVSSPTAMMSAPLEVQLRPRNGACSIQNLAEAIDGKGL 925

Human   618 ---------------------------------VDASED--------EHELNQLLNEALLERESA 641
                                             ||..||        :.|:::.:.:.:....:.
  Fly   926 IIEDESTTDWIPEIPFKNLNSPEDGLNRADSILVDTKEDHRVSVAVLDEEIDEFIEQNIQINSNK 990

Human   642 QVVKKRNTFL--LSMRFMDPEMETRYSVEKEKQSGAAFSCSCVVLLCTALVEILIDPWLMTNYVT 704
            ::   |..:|  .:::|.|...|.::...:|....:...|..|:.:...|.:::|.|......:.
  Fly   991 EI---RREYLNPWTLKFKDKSQEQKFCQLREDMFRSNMLCVFVIWIFMVLCQVIIIPRCTRLIIC 1052

Human   705 FMVGEILLLILTICSLAAIFPRAFPKKLVAFSTWIDRTRWARNTWAMLAIFILVMANVVDMLSC- 768
            ..||.::|....:..:|..|| ..|:.|...|..:...|..|..:....|..:.|.:.:.::.| 
  Fly  1053 LSVGTVILTFCCVLVMAEEFP-GLPRCLKTNSAKLVHQRQRRTLFICGVIVSMCMLSAIGLVLCP 1116

Human   769 --------------------------------LQYY---------------------------TG 774
                                            |..|                           :|
  Fly  1117 SSTYIGTADEHSRFLRMVSPYSNISMTEKEFKLNVYLSATIHHNITISTPASGGPTPLVDITSSG 1181

Human   775 PS-------------NAT---------------------------------AGMETEGSCLENPK 793
            ||             |.|                                 :..:.||.| .:|:
  Fly  1182 PSDEFVRSTLNALTLNLTPPLPQSHRPYTLTTNGHSVSLSNLSYSDASVMQSSSDVEGQC-AHPE 1245

Human   794 YYNYVAVLSLIATIMLVQVSHMVKLTLMLLVAGAVATINLYAWRPVFDEYDHKRFREHD-LPMVA 857
            |..:..||.|::....:::.::||..:.|.:.....|:.:            .:|...| ..:|.
  Fly  1246 YLVFTWVLCLVSLATALKLYYLVKALMALAMVAFYTTLIM------------MKFGSGDSFSLVE 1298

Human   858 LEQMQGFNPGLNGTDSRLPLVPSKYSMTVMVFLMMLSFYYFSRHVEKLARTLFLWKIEVHDQKER 922
            |              |||.: |....|.:::...::...|.:|.||..:|..|:||.:...:...
  Fly  1299 L--------------SRLGM-PLGVQMLILLISFLVMVCYHARLVEVTSRLDFIWKEQAERELTN 1348

Human   923 VYEMRRWNEALVTNMLPEHVARHFLGSKKRDEELYSQTYDEIGVMFASLPNFADFYTEESINNGG 987
            :...|..|:.|:.|:||:|||.::| |.:..:||||:.::..||||||:|||.|||:|: |:||.
  Fly  1349 MKSNRALNDTLIKNILPDHVATYYL-SDEHTDELYSKMHNLCGVMFASIPNFQDFYSED-IDNGK 1411

Human   988 IECLRFLNEIISDFDSLLDNPKFRVITKIKTIGSTYMAASGVTPD-VNTNGFASSNKEDKSERER 1051
             .|:|.|||||.|||.||:.|:|..:.||||:|:|||||:|:..: :...|..|   ||.     
  Fly  1412 -ACIRILNEIICDFDELLEEPRFASVEKIKTVGATYMAAAGLNHEHLRLRGETS---EDS----- 1467

Human  1052 WQHLADLADFALAMKDTLTNINNQSFNNFMLRIGMNKGGVLAGVIGARKPHYDIWGNTVNVASRM 1116
               :.||.:||.|||..|..||..:||||.||:|:..|.:::||||||||.||||||||||||||
  Fly  1468 ---VCDLVEFAFAMKQKLEEINGDAFNNFQLRVGICSGPLVSGVIGARKPVYDIWGNTVNVASRM 1529

Human  1117 ESTGVMGNIQVVEETQVILREYGFRFVRRGPIFVKGKGELLTFFL--KGRDK------------- 1166
            :|||....:||.|.|..:|...|:..|:||.|.|||||.:.||::  ||..:             
  Fly  1530 DSTGENWRVQVPENTAELLCSRGYTCVKRGEIAVKGKGMMTTFYVHPKGISESQLISPVRMPAGI 1594

Human  1167 -LATFPNGPSVTLPH 1180
             ||..||....|..|
  Fly  1595 PLAQTPNLQRQTSHH 1609

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ADCY3XP_011530791.1 AC_N <44..303 CDD:292831 75/287 (26%)
CYCc 273..490 CDD:214485 104/220 (47%)
Guanylate_cyc 310..516 CDD:278633 104/209 (50%)
CYCc 925..1143 CDD:214485 109/218 (50%)
Guanylate_cyc 956..1163 CDD:278633 108/209 (52%)
Ac78CNP_001262138.1 AC_N <288..551 CDD:292831 74/283 (26%)
CYCc 526..729 CDD:214485 104/224 (46%)
Guanylate_cyc 566..753 CDD:278633 103/208 (50%)
DUF1053 929..1020 CDD:283888 11/93 (12%)
CYCc 1353..1554 CDD:214485 109/214 (51%)
Guanylate_cyc 1381..1576 CDD:278633 108/207 (52%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG2114
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100296
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.710

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