DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CPSF4 and cpsf4

DIOPT Version :9

Sequence 1:	XP_011514057.1	Gene:	CPSF4 / 10898	HGNCID:	2327	Length:	274	Species:	Homo sapiens
Sequence 2:	XP_012825775.1	Gene:	cpsf4 / 493312	XenbaseID:	XB-GENE-948302	Length:	279	Species:	Xenopus tropicalis

Alignment Length:	284	Identity:	245/284 - (86%)
Similarity:	256/284 - (90%)	Gaps:	15/284 - (5%)

- Green bases have known domain annotations that are detailed below.

Human     1 MQEIIASVDHIKFDLEIAVEQQLGAQPLPFPGMDKSGAAVCEFFLKAACGKGGMCPFRHISGEKT 65
            |||:||.||||:||||:|||||||||||||||||||||||||||||:||||||||||||||||||
Frog     1 MQELIACVDHIRFDLELAVEQQLGAQPLPFPGMDKSGAAVCEFFLKSACGKGGMCPFRHISGEKT 65

Human    66 VVCKHWLRGLCKKGDQCEFLHEYDMTKMPECYFYSKFGECSNKECPFLHIDPESKIKDCPWYDRG 130
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Frog    66 VVCKHWLRGLCKKGDQCEFLHEYDMTKMPECYFYSKFGECSNKECPFLHIDPESKIKDCPWYDRG 130

Human   131 FCKH----------GPLCRHRHTRRVICVNYLVGFCPEGPSCKFMQLLVTSPRFELPMGTTEQPP 185
            ||||          ||||||||||||||||||||||.|||:||||.     ||||||||||||||
Frog   131 FCKHVALNLYYVFSGPLCRHRHTRRVICVNYLVGFCIEGPNCKFMH-----PRFELPMGTTEQPP 190

Human   186 LPQQTQPPAKQSNNPPLQRSSSLIQLTSQNSSPNQQRTPQVIGVMQSQNSSAGNRGPRPLEQVTC 250
            ||||||...||:||..|||||||||||||||..:|||:||.|||||||:.:.||||||||:||||
Frog   191 LPQQTQTQQKQNNNQVLQRSSSLIQLTSQNSPVSQQRSPQTIGVMQSQSGNQGNRGPRPLDQVTC 255

Human   251 YKCGEKGHYANRCTKGHLAFLSGQ 274
            ||||||||||||||||||||||||
Frog   256 YKCGEKGHYANRCTKGHLAFLSGQ 279

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CPSF4	XP_011514057.1	YTH1	<25..>161	CDD:227416	133/145 (92%)
CPSF4	XP_011514057.1	COG5222	<231..>263	CDD:227547	26/31 (84%)
cpsf4	XP_012825775.1	YTH1	<25..186	CDD:227416	146/165 (88%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	183	1.000	Domainoid score	I17150
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H38216
Inparanoid	1	1.050	540	1.000	Inparanoid score	I7159
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG49855
OrthoDB	1	1.010	-	-		D1472764at2759
OrthoFinder	1	1.000	-	-		FOG0002750
OrthoInspector	1	1.000	-	-		oto149943
Panther	1	1.100	-	-	LDO	PTHR23102
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2013
SonicParanoid	1	1.000	-	-		X2133
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	14	14.110