DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CPSF4 and cpsf4

DIOPT Version :9

Sequence 1:	XP_011514057.1	Gene:	CPSF4 / 10898	HGNCID:	2327	Length:	274	Species:	Homo sapiens
Sequence 2:	NP_571084.1	Gene:	cpsf4 / 30203	ZFINID:	ZDB-GENE-990415-180	Length:	271	Species:	Danio rerio

Alignment Length:	276	Identity:	230/276 - (83%)
Similarity:	244/276 - (88%)	Gaps:	7/276 - (2%)

- Green bases have known domain annotations that are detailed below.

Human     1 MQEIIASVDHIKFDLEIAVEQQLGAQPLPFPGMDKSGAAVCEFFLKAACGKGGMCPFRHISGEKT 65
            |||:||:|||||||||||||||||||||||||||||||||||:|::|||.|||||||||||||||
Zfish     1 MQELIATVDHIKFDLEIAVEQQLGAQPLPFPGMDKSGAAVCEYFMRAACMKGGMCPFRHISGEKT 65

Human    66 VVCKHWLRGLCKKGDQCEFLHEYDMTKMPECYFYSKFGECSNKECPFLHIDPESKIKDCPWYDRG 130
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Zfish    66 VVCKHWLRGLCKKGDQCEFLHEYDMTKMPECYFYSKFGECSNKECPFLHIDPESKIKDCPWYDRG 130

Human   131 FCKHGPLCRHRHTRRVICVNYLVGFCPEGPSCKFMQLLVTSPRFELPMGTTEQPPLPQQTQPPAK 195
            ||||||.||||||||||||||||||||||.|||||.     ||||||||.|||||||||.|...|
Zfish   131 FCKHGPDCRHRHTRRVICVNYLVGFCPEGKSCKFMH-----PRFELPMGATEQPPLPQQVQTQQK 190

Human   196 QSNNPPLQRSS-SLIQLTSQN-SSPNQQRTPQVIGVMQSQNSSAGNRGPRPLEQVTCYKCGEKGH 258
            |.|..|:.||| ||||||:.| |:.|.||.|..:|::.|.:...|.||||||:||||||||||||
Zfish   191 QQNMQPINRSSQSLIQLTNPNISNNNHQRIPNAVGIVHSNSHMGGARGPRPLDQVTCYKCGEKGH 255

Human   259 YANRCTKGHLAFLSGQ 274
            |||:||||||||||||
Zfish   256 YANKCTKGHLAFLSGQ 271

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CPSF4	XP_011514057.1	YTH1	<25..>161	CDD:227416	130/135 (96%)
CPSF4	XP_011514057.1	COG5222	<231..>263	CDD:227547	23/31 (74%)
cpsf4	NP_571084.1	YTH1	<38..218	CDD:227416	156/184 (85%)
		ZnF_C3H1	63..88	CDD:214632	24/24 (100%)
		ZnF_C3H1	119..142	CDD:214632	21/22 (95%)
		ZnF_C3H1	143..168	CDD:214632	22/29 (76%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C194323661
Domainoid	1	1.000	178	1.000	Domainoid score	I14729
eggNOG	1	0.900	-	-		E1_COG5084
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H38216
Inparanoid	1	1.050	505	1.000	Inparanoid score	I6447
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG49855
OrthoDB	1	1.010	-	-		D1472764at2759
OrthoFinder	1	1.000	-	-		FOG0002750
OrthoInspector	1	1.000	-	-		oto48082
orthoMCL	1	0.900	-	-		OOG6_103251
Panther	1	1.100	-	-	LDO	PTHR23102
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2013
SonicParanoid	1	1.000	-	-		X2133
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	1	1.500	-	-
	18	18.300