Protein Alignment PPARGC1A and RIM4

DIOPT Version :10

• Sequence 1: NP_001317680.1
• Gene: PPARGC1A / 10891
• HGNCID: 9237
• Length: 803
• Species: Homo sapiens
• Sequence 2: NP_011839.1
• Gene: RIM4 / 856361
• SGDID: S000001016
• Length: 713
• Species: Saccharomyces cerevisiae
• Alignment Length: 719
• Identity: 132/719 - (18%)
• Similarity: 235/719 - (32%)
• Gaps: 180/719 - (25%)

Human     2 DETSPRLEEDWKKVLQREAGWQCAALVGEDQPLCPDLPELDLS-ELDVNDLDTDSFLGGLKWCSD 65
            |..|..|:.|.:.|::.:.          ||.|..::..|... :.|..|.|||
Yeast    13 DPPSNGLKADSELVIREDI----------DQFLPSEVSSLGSDHQNDGEDSDTD----------- 56

Human    66 QSEIISNQYNNEPSNIFEKIDEENEANLLAVLTETLDSLPVDEDGLPS--------FDALTDGDV 122
                 |:.:..:|.   :.:|||:...    .|.|..|...:..|.||        ..||:|.::
Yeast    57 -----SDNFLQDPE---DDVDEESTGR----GTVTTTSTSTESRGRPSSCIFVASLAAALSDDEL 109

Human   123 ---TTDNEASPSSMPDGTPPPQEAEEPSLLKKLLLAPANTQLSYNECSGLSTQNHA--------N 176
               .|:|......:              ...|:|...||...::.:.:......||        .
Yeast   110 CLSVTENFKKYGDL--------------ARVKVLRDNANRPYAFVQYNNDHDAKHALIRAQGTLL 160

Human   177 HNHRIRTNPAIV------KTENSWS-NKAKSIC------QQQKPQRRPCSELLKYLTTNDDPPHT 228
            :..|:|..||.|      |.:.|.. |:...||      :|..|.|.......:|         |
Yeast   161 NGRRLRCEPAKVNRTLYLKNQQSIDFNEISQICEKFGGLEQIVPDRTDNQYTRRY---------T 216

Human   229 KPTENRNS------SRDKCTSKKKSHTQSQSQHLQAKPTTLSLPLTPESPNDPKG------SPFE 281
            .|..:.||      .||...   :::.     :|:..|..:.  ...::.|.||.      |.|:
Yeast   217 YPISSANSWFVQFVYRDDAI---RAYA-----NLRTDPNWII--EWAQNINVPKNYNLLHKSKFK 271

Human   282 NKTIERTLSVELSGTAGLTPPTTPPHKANQDNPFRASPKLKSSCKTVVPPPSKKPRYSESSGTQG 346
            :....:...: ::............:..|:::..|....::..|..|                .|
Yeast   272 SSKYHQNNGI-INNDGSNNNDNNNSNNNNREDSRRNGDVIEEECGHV----------------HG 319

Human   347 NNSTKK-------GPEQSELYAQLSKSSVLTGGHEERKTKRPSLRLFGDHDYCQSIN---SKTEI 401
            ::|.:|       ..|..:....:.|.|:..|..::..|:....|.|..|...|.||   ..|.|
Yeast   320 SDSEEKLTSDGIYDDEDKDSEITIDKRSIFVGQLDKETTREELNRRFSTHGKIQDINLIFKPTNI 384

Human   402 LINISQELQDSRQLENKDVSSDWQGQICSSTDSDQCYLRETLEAS-KQVSPCSTRKQLQDQEIRA 465
            ...|..|.:::             ......:::...:|.:|:... |:|.....|| ...:...:
Yeast   385 FAFIKYETEEA-------------AAAALESENHAIFLNKTMHVQYKEVGGRHNRK-FSGKNGGS 435

Human   466 ELNKHFGHPSQAVFDDEADKTGELRDSDFSNEQFSKLPMFINSGLAMDGLFDDSEDESDKLSYPW 530
            ..|.|      ..|...:.||       |:..:.:..|..||....|.|   .|:.||:.: .|:
Yeast   436 NFNHH------QFFSTRSGKT-------FTGPELNLAPPPINMYRKMSG---GSQQESETM-MPY 483

Human   531 DGTQSYSLFNVSPSCSSFNSPCRDSVSPPKSLFSQRPQRMRSRSRSFSRHRSCSRSPYSRSRSRS 595
            .......:....|:.:|.:.  .|...|..|.|.:....:|.:|...|.....|:|..|.:.|.:
Yeast   484 MPMGPMPMGPPPPNAASLSD--FDMFPPSYSTFMKGMMPLRRKSMPNSWSSPSSKSVNSENESVN 546

Human   596 PGSRSSSRSCYYYESSHYRHRTHRNSPLYVRSRSRSPYSRRPRYDSYEEYQHERLKREEYRREYE 660
            .|..:|.......|||. |:....:...|..|.:.:..:.....:|       ...:.:|::.|.
Yeast   547 GGDENSELPSEIPESSG-RYNAANSFTTYNNSSAGNSNNNNNNNNS-------NSNKSQYKKRYA 603

Human   661 KRES 664
            :|.|
Yeast   604 RRSS 607

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PPARGC1A	NP_001317680.1	Complexin_NTD	641..676	CDD:459253	5/24 (21%)
		RRM_PPARGC1A	680..770	CDD:410034
RIM4	NP_011839.1	RRM1_RIM4_like	91..176	CDD:409887	18/98 (18%)
		RRM_SF	176..242	CDD:409669	15/82 (18%)
		SF-CC1	300..>378	CDD:273721	17/93 (18%)
		RRM2_RIM4_like	343..420	CDD:409888	17/89 (19%)
		YppG	615..>669	CDD:372950