Protein Alignment PPARGC1A and srl

DIOPT Version :10

• Sequence 1: NP_001317680.1
• Gene: PPARGC1A / 10891
• HGNCID: 9237
• Length: 803
• Species: Homo sapiens
• Sequence 2: NP_649469.2
• Gene: srl / 40562
• FlyBaseID: FBgn0037248
• Length: 1067
• Species: Drosophila melanogaster
• Alignment Length: 957
• Identity: 217/957 - (22%)
• Similarity: 344/957 - (35%)
• Gaps: 240/957 - (25%)

Human     2 DETSPRLEEDWKKVLQREAGWQCAALVGEDQPLCPDLPELDLSELDVNDLD------TDSFLGGL 60
            :|.||||:.....:...::..:..........:..::..|.|| :|||:.|      .|.|...|
  Fly   166 EEKSPRLQVVHNNIGNLQSSCERKGRTLSTNTIISEVDALGLS-IDVNNFDLADFITKDDFAENL 229

Human    61 KWC------SDQSEIISNQYNNEP-------SNIFEKI--------DEENEANLLAVLTETLDSL 104
            ..|      ..|::|.||...:.|       :.|..|.        |.:.:::.: :..||:|.|
  Fly   230 NACRKKESLQAQAQIKSNTLADVPILLNPPVATIVAKPGVPSSKPGDSDYDSDSI-IDVETVDVL 293

Human   105 PVDEDGLPSFDALTD-----------GDVTTDNEASPSSMPDGTPPPQEAEEPSLLKKLLLAPAN 158
            .::...:.|.|....           .:|..|...||.|....||..:|.:...|....|..||:
  Fly   294 DMNMANIWSIDKPAKMGQTPDELRYVDNVKADPSWSPRSAKKTTPTIKENKPEQLGNHQLAVPAS 358

Human   159 TQLSYNECSGLSTQNHANHNHRIRTNPAIVKTENSWSNKAKSICQQQKP--QRRPCS-------- 213
            .:..:.....:..:...:...|...:|::.|...:.:.||......::|  :...|:
  Fly   359 NKPKHKNICLVPNKKQCDFLKRKVGSPSLSKLTKATTKKATESMSNKQPSVKNTQCTGLGLGGKN 423

Human   214 -ELLKYLTTNDDPPHTKPTENRNSSRDKCTSKKKSHTQSQSQHLQAKPTTLSL---PLTPESPND 274
             .|||              :.|:::...|.:|            ...|.|||.   .|||
  Fly   424 LSLLK--------------QERDAALSVCAAK------------PIAPPTLSTTTPTLTP----- 457

Human   275 PKGSPFENK-TIERTLSVELSGTAGLTPPTTPPHKANQDNPFRASPKLKSSCKTVVPPPSKKPRY 338
                |.:.| .:|........|...:.|..|||.:|          |::.:.|.:.|.|..||..
  Fly   458 ----PAKRKLNLEEYKQRRCGGVGAVYPKPTPPKQA----------KIEVAAKRIAPTPVSKPTP 508

Human   339 SESSGTQGN--NSTK-KGPEQSELYAQ---LSKSSVL-----------------TGGHEERKTKR 380
            |.......|  ||.| ...|||.|...   ::|:.||                 ......|.||.
  Fly   509 SPKKAEIVNIVNSLKCPRTEQSSLPMDPITMAKNKVLRMLEMKRAQQLKIIDSRVSAKVPRVTKL 573

Human   381 PSLRLFGDHDYC-QSINSKTEILINISQELQDSRQLENKDVSSDWQGQICSSTDSDQCYLRETLE 444
            |.|:......|| ::.:..|||           ..|.|| :..|::..|..|.   .|....|:.
  Fly   574 PPLKDIVKDTYCMETEDPGTEI-----------APLSNK-LHPDYEEIIIVSA---SCNTDITIP 623

Human   445 ASKQVSPCSTRKQLQDQ----------------------EIRAELNKHFGHPSQAVFDDEADKTG 487
            .: |:|..|.|..|:..                      .|::|:.:...:.:.:.....|.|..
  Fly   624 PN-QLSKASPRSLLKSSVLLYNISNGQDANKNMSNSLIASIQSEVARQTSNTTLSTIQSNATKVM 687

Human   488 ELRDSDFSNEQ---FSKLPM-FINSGLAMDGLFDDSEDESDKLSYP-----------------WD 531
            ...|.:..:.:   ...||. .:...|.......|.:.|...|:.|                 ..
  Fly   688 SSADKNCQHGEDMVIMHLPKDRVRKTLVSIATQTDLQPEFPLLTLPPKRQSRERTRRNYRRRRTQ 752

Human   532 GTQSYSLFNVSPSCSSFNSPCRDSVSPPKSLFSQRPQRMRSRSRSFSRHR----------SCSRS 586
            |:.|    |:|.|.|.|:|.|...||          .|.||:..|..:.|          |....
  Fly   753 GSGS----NMSTSSSDFSSDCSSLVS----------HRSRSQYDSIDQLRNLDVAATCGGSIGNG 803

Human   587 PY-SRSRSRSPGSRSSSRSCYYYESSHYRHRTHRNSPLYVRSRSRSPYSRRPRYDSYEEYQHERL 650
            .| |||..|   .|||..|..|.|:..||.|..|.|....|||::...|........|:...||
  Fly   804 GYSSRSTQR---HRSSVSSSSYSENGQYRRRQRRTSYNKRRSRNQKRGSTSSSCSGSEKSDRER- 864

Human   651 KREEYRREYEKRESERAKQRERQ--------------------RQKAIEERRVIYVGKIRPDTTR 695
            .|..:|:....|...|:|...|.                    .|.|:||||::|||:|..:||:
  Fly   865 SRSPHRKLRHSRSRSRSKSDTRYPNNNSSSNNNNRRGFFDRNVSQPAVEERRIVYVGRIEQETTK 929

Human   696 TELRDRFEVFGEIEECTVNLRDDGDSYGFITYRYTCDAFAALENGYTLRRSNETDFELYFCGRKQ 760
            ..||.:|..:|.|::.|::.:::|..|||:||....|||.|::..:  |.|..:.:::.|.||:.
  Fly   930 EILRRKFLPYGSIKQITIHYKENGMKYGFVTYERAQDAFTAIDTSH--RDSQISMYDISFGGRRA 992

Human   761 FFKSNYADLDS------NSDDFDPASTKSKYDSLDFDSLLKEAQRSL 801
            |.:|:|||||:      ||..|...:.........|::||.:.:..|
  Fly   993 FCRSSYADLDNAGINNYNSYVFPKEAPAPNVVEDSFEALLLQVKAKL 1039

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PPARGC1A	NP_001317680.1	Complexin_NTD	641..676	CDD:459253	9/54 (17%)
		RRM_PPARGC1A	680..770	CDD:410034	35/89 (39%)
srl	NP_649469.2	RRM_PPARGC1A_like	914..1002	CDD:409793	35/89 (39%)