Protein Alignment PPARGC1A and ppargc1a

DIOPT Version :10

• Sequence 1: NP_001317680.1
• Gene: PPARGC1A / 10891
• HGNCID: 9237
• Length: 803
• Species: Homo sapiens
• Sequence 2: XP_002936759.2
• Gene: ppargc1a / 100491667
• XenbaseID: XB-GENE-494718
• Length: 786
• Species: Xenopus tropicalis
• Alignment Length: 789
• Identity: 599/789 - (75%)
• Similarity: 665/789 - (84%)
• Gaps: 13/789 - (1%)

Human    18 REAGW---QCAALVGEDQPLCPDLPELDLSELDVNDLDTDSFLGGLKWCSDQSEIISNQYNNEPS 79
            :::.|   :|||||||||||||||||||||||||||||.|||||||||.|||||.|||||::|.|
 Frog     8 QDSVWSDIECAALVGEDQPLCPDLPELDLSELDVNDLDADSFLGGLKWYSDQSENISNQYSSESS 72

Human    80 NIFEKIDEENEANLLAVLTETLDSLPVDEDGLPSFDALTDGDVTTDNEASPSSMPDGTPPPQEAE 144
            |||||||||||.||||||||||||||||||||||||||||||||.:::.|.|||||||||.||||
 Frog    73 NIFEKIDEENEENLLAVLTETLDSLPVDEDGLPSFDALTDGDVTNEHDPSLSSMPDGTPPTQEAE 137

Human   145 EPSLLKKLLLAPANTQLSYNECSGLSTQNHANHNHRIRTNPAIVKTENSWSNKAKSICQQQKPQR 209
            ||||||||||||||.||.||||.|.:|||||:.:.|||||.|:||||||||||.|:||..|||.|
 Frog   138 EPSLLKKLLLAPANAQLIYNECIGFTTQNHASPSQRIRTNSAVVKTENSWSNKPKTICHSQKPPR 202

Human   210 RPCSELLKYLTTNDDPPHTKPTENRNSSRDKCTSKKKSHTQSQSQHLQAKPTTLSLPLTPESPND 274
            |||||||||||:|||||.||.||:|||..|||:||||.:.|.| .|.||:.|:||||||||||||
 Frog   203 RPCSELLKYLTSNDDPPQTKSTESRNSRLDKCSSKKKPYLQPQ-PHYQARATSLSLPLTPESPND 266

Human   275 PKGSPFENKTIERTLSVELSGTAGLTPPTTPPHKANQDNPFRASPKLKSSCKTVVPPPSKKPRYS 339
            ||.||||:|||||.|.:||||||||||||||||||||:||||.||||| |||:.| ||:||.||.
 Frog   267 PKSSPFESKTIERGLCMELSGTAGLTPPTTPPHKANQENPFRTSPKLK-SCKSSV-PPAKKSRYI 329

Human   340 ESSGTQGNNSTKKGPEQSELYAQLSKSSVLTGGHEERKTKRPSLRLFGDHDYCQSINSKTEILIN 404
            |||..|.....|||||||||||||||::|:. |.||:|.|||||||||||||||.:|||:||.|:
 Frog   330 ESSSIQVLYPAKKGPEQSELYAQLSKATVVI-GQEEKKAKRPSLRLFGDHDYCQFMNSKSEIHIS 393

Human   405 ISQELQDSRQLENKDVSSDWQGQICSSTDSDQCYLRETLEASKQVSPCSTRKQLQDQEIRAELNK 469
            :|||||.||.||.||.....:.::||.||.:||. :::|..:...|..|.|||||||||||||||
 Frog   394 LSQELQASRHLECKDPLPGKELKVCSYTDQEQCQ-KDSLPVTMPSSQNSHRKQLQDQEIRAELNK 457

Human   470 HFGHPSQAVFDDEADKTGELRDSDFSNEQFSKLPMFINSGLAMDGLFDDSEDESDKLSYPWDGTQ 534
            |||||:|||::||. |..||.|:.:|:||.|:||||:.:||.:|.||||||||:|||.|.||.||
 Frog   458 HFGHPTQAVYNDET-KISELVDNKYSDEQLSRLPMFLTAGLEIDSLFDDSEDENDKLCYTWDETQ 521

Human   535 SYSLFNVSPSCSSFNSPCRDSVSPPKSLFSQRPQRMRSRSRSFSRHRSCSRSPYSRSRSRSPGSR 599
            |||||:.|||||:||||.|.|||||.|||||| ...||||||||:.||.|.|||||||||||.||
 Frog   522 SYSLFDESPSCSTFNSPSRYSVSPPTSLFSQR-ICSRSRSRSFSQFRSSSLSPYSRSRSRSPSSR 585

Human   600 SSSRSCYYYESSHYRHRTHRNSPLYVRSRSRSPYSRRPRYDSYEEYQHERLKREEYRREYEKRES 664
            |||.||..||:.|.|.:|   ||:|.||||||||.||||||||||||||||||||||:|||||||
 Frog   586 SSSGSCCCYETDHCREKT---SPMYARSRSRSPYGRRPRYDSYEEYQHERLKREEYRKEYEKRES 647

Human   665 ERAKQRERQRQKAIEERRVIYVGKIRPDTTRTELRDRFEVFGEIEECTVNLRDDGDSYGFITYRY 729
            ||||||||||||||||.|||:|||:||:.:|.|||.|||||||||||||||||||:.||||||||
 Frog   648 ERAKQRERQRQKAIEEHRVIFVGKMRPNMSRAELRARFEVFGEIEECTVNLRDDGNCYGFITYRY 712

Human   730 TCDAFAALENGYTLRRSNETDFELYFCGRKQFFKSNYADLDSNSDDFDPASTKSKYDSLDFDSLL 794
            |||||||||||||||||||.|||:.||.|||..|||||||||||||||||||||||||:||||||
 Frog   713 TCDAFAALENGYTLRRSNEPDFEVCFCERKQVCKSNYADLDSNSDDFDPASTKSKYDSMDFDSLL 777

Human   795 KEAQRSLRR 803
            |||||||||
 Frog   778 KEAQRSLRR 786

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PPARGC1A	NP_001317680.1	Complexin_NTD	641..676	CDD:459253	33/34 (97%)
		RRM_PPARGC1A	680..770	CDD:410034	73/89 (82%)
ppargc1a	XP_002936759.2	Complexin_NTD	624..659	CDD:459253	33/34 (97%)
		RRM_PPARGC1A	663..753	CDD:410034	73/89 (82%)