Protein Alignment RAB10 and Rab3

DIOPT Version :10

• Sequence 1: NP_057215.3
• Gene: RAB10 / 10890
• HGNCID: 9759
• Length: 200
• Species: Homo sapiens
• Sequence 2: NP_523687.1
• Gene: Rab3 / 36127
• FlyBaseID: FBgn0005586
• Length: 220
• Species: Drosophila melanogaster
• Alignment Length: 196
• Identity: 97/196 - (49%)
• Similarity: 139/196 - (70%)
• Gaps: 9/196 - (4%)

Human     2 AKKTYDLLFKLLLIGDSGVGKTCVLFRFSDDAFNTTFISTIGIDFKIKTVELQGKKIKLQIWDTA 66
            |.:.:|.:||||:||:|.||||..|||::||:|.:.|:||:|||||:|||....|::||||||||
  Fly    14 ADQNFDYMFKLLIIGNSSVGKTSFLFRYADDSFTSAFVSTVGIDFKVKTVFRHDKRVKLQIWDTA 78

Human    67 GQERFHTITTSYYRGAMGIMLVYDITNGKSFENISKWLRNIDEHANEDVERMLLGNKCDMDDKRV 131
            ||||:.||||:|||||||.:|:||:||..||.::..|:..|..::.::.:.:|:||||||:|:||
  Fly    79 GQERYRTITTAYYRGAMGFILMYDVTNEDSFNSVQDWVTQIKTYSWDNAQVILVGNKCDMEDQRV 143

Human   132 VPKGKGEQIAREHGIRFFETSAKANINIEKAFLTLAEDILRKTPVKEPNSENVDISS---GGGVT 193
            :...:|.|:|.:.|:.|||||||.|:|::..|..|.:.|..|.      ||::|...   |||..
  Fly   144 ISFERGRQLADQLGVEFFETSAKENVNVKAVFERLVDIICDKM------SESLDADPTLVGGGQK 202

Human   194 G 194
            |
  Fly   203 G 203

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RAB10	NP_057215.3	Rab8_Rab10_Rab13_like	7..173	CDD:206659	88/165 (53%)
		Switch 1. /evidence=ECO:0000250|UniProtKB:P62820	32..46		7/13 (54%)
		Switch 2. /evidence=ECO:0000250|UniProtKB:P62820	64..81		13/16 (81%)
Rab3	NP_523687.1	Rab3	21..185	CDD:206657	87/163 (53%)