Protein Alignment RAB10 and Rab2

DIOPT Version :10

• Sequence 1: NP_057215.3
• Gene: RAB10 / 10890
• HGNCID: 9759
• Length: 200
• Species: Homo sapiens
• Sequence 2: NP_477090.1
• Gene: Rab2 / 35577
• FlyBaseID: FBgn0014009
• Length: 213
• Species: Drosophila melanogaster
• Alignment Length: 212
• Identity: 94/212 - (44%)
• Similarity: 134/212 - (63%)
• Gaps: 16/212 - (7%)

Human     5 TYDLLFKLLLIGDSGVGKTCVLFRFSDDAFNTTFISTIGIDFKIKTVELQGKKIKLQIWDTAGQE 69
            :|..|||.::|||:||||:|:|.:|:|..|......|||::|..:.:.:.||:||||||||||||
  Fly     2 SYAYLFKYIIIGDTGVGKSCLLLQFTDKRFQPVHDLTIGVEFGARMITIDGKQIKLQIWDTAGQE 66

Human    70 RFHTITTSYYRGAMGIMLVYDITNGKSFENISKWLRNIDEHANEDVERMLLGNKCDMDDKRVVPK 134
            .|.:||.||||||.|.:||||||..::|.:::.||.:..:|:|.::..||:|||.|:|.:|.|.|
  Fly    67 AFRSITRSYYRGAAGALLVYDITRRETFNHLTTWLEDARQHSNSNMVIMLIGNKSDLDSRREVKK 131

Human   135 GKGEQIAREHGIRFFETSAKANINIEKAFLTLAEDILRKTP--VKEPNSE-------------NV 184
            .:||..|||||:.|.||||:...|:|:||:..|::|..|..  |.:.|:|             |.
  Fly   132 EEGEAFAREHGLVFMETSARTAANVEEAFINTAKEIYEKIQEGVFDINNEANGIKIGQQHSPTNP 196

Human   185 DISSGGGVTG-WKSKCC 200
            .:...||..| ..|.||
  Fly   197 SLPGAGGAAGAANSGCC 213

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RAB10	NP_057215.3	Rab8_Rab10_Rab13_like	7..173	CDD:206659	82/165 (50%)
		Switch 1. /evidence=ECO:0000250|UniProtKB:P62820	32..46		4/13 (31%)
		Switch 2. /evidence=ECO:0000250|UniProtKB:P62820	64..81		12/16 (75%)
Rab2	NP_477090.1	PLN03108	1..213	CDD:178655	92/210 (44%)