Protein Alignment RAB10 and Rab35

DIOPT Version :10

• Sequence 1: NP_057215.3
• Gene: RAB10 / 10890
• HGNCID: 9759
• Length: 200
• Species: Homo sapiens
• Sequence 2: NP_608373.1
• Gene: Rab35 / 33014
• FlyBaseID: FBgn0031090
• Length: 201
• Species: Drosophila melanogaster
• Alignment Length: 204
• Identity: 98/204 - (48%)
• Similarity: 139/204 - (68%)
• Gaps: 17/204 - (8%)

Human     6 YDLLFKLLLIGDSGVGKTCVLFRFSDDAFNTTFISTIGIDFKIKTVELQGKKIKLQIWDTAGQER 70
            :|.|||||:||||||||:.:|.|||||.|:.::|:|||:||||:||:::|.::||||||||||||
  Fly     5 FDHLFKLLIIGDSGVGKSSLLIRFSDDTFSGSYITTIGVDFKIRTVDIEGMRVKLQIWDTAGQER 69

Human    71 FHTITTSYYRGAMGIMLVYDITNGKSFENISKWLRNIDEHANEDVERMLLGNKCDMDDKRVVPKG 135
            |.|||::||||..|:::|||:|||:||.|:.:||..|..:. :.|:::|:|||.|..|::||...
  Fly    70 FRTITSTYYRGTHGVIVVYDVTNGESFANVRRWLEEIQNNC-DVVKKVLVGNKNDDPDRKVVITE 133

Human   136 KGEQIAREHGIRFFETSAKANINIEKAFLTLAEDILRKTPVKEPNSENVDI---------SSGGG 191
            ..::.|::..|..||||||.|||:|..||::...:|.......||.:..|.         |.||
  Fly   134 DAQRFAKQMDIELFETSAKDNINVENMFLSITRQVLDHKLRTSPNEQQKDTLHLKPNPKGSKGG- 197

Human   192 VTGWKSKCC 200
                  |||
  Fly   198 ------KCC 200

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RAB10	NP_057215.3	Rab8_Rab10_Rab13_like	7..173	CDD:206659	89/165 (54%)
		Switch 1. /evidence=ECO:0000250|UniProtKB:P62820	32..46		6/13 (46%)
		Switch 2. /evidence=ECO:0000250|UniProtKB:P62820	64..81		13/16 (81%)
Rab35	NP_608373.1	Rab35	3..201	CDD:133310	98/204 (48%)