Protein Alignment RAB10 and Rab40

DIOPT Version :10

• Sequence 1: NP_057215.3
• Gene: RAB10 / 10890
• HGNCID: 9759
• Length: 200
• Species: Homo sapiens
• Sequence 2: NP_727611.1
• Gene: Rab40 / 32195
• FlyBaseID: FBgn0030391
• Length: 265
• Species: Drosophila melanogaster
• Alignment Length: 207
• Identity: 81/207 - (39%)
• Similarity: 113/207 - (54%)
• Gaps: 20/207 - (9%)

Human     4 KTYDLLFKLLLIGDSGVGKTCVLFRFSDDAFNTTFISTIGID----------FKIKTVELQGKKI 58
            |.||.|.|:||:|||.|||..:|....|.:..:.|.|  |.|          :|..|:.|:||::
  Fly     6 KDYDYLLKVLLVGDSDVGKHEILSNLEDPSTESPFCS--GNDCTSHILQTVAYKTTTILLEGKRV 68

Human    59 KLQIWDTAGQERFHTITTSYYRGAMGIMLVYDITNGKSFENISKWLRNIDEHANEDVERMLLGNK 123
            |||:|||:||.||.||..||.|||.||:|||||||..||:.|.:||:.:|||| ..:.::|:||:
  Fly    69 KLQLWDTSGQGRFCTIIRSYSRGAQGIILVYDITNKWSFDGIDRWLKEVDEHA-PGIPKVLVGNR 132

Human   124 CDMDDKRVVPKGKGEQIAREHGIRFFETSAKANINIEKAFLTLAEDILRKTPVKEPNSENVDISS 188
            ..:..||.|...:.|..|..:.:..||.|...|.||.::|..||...|.:..::.       |..
  Fly   133 LHLAFKRQVAAKQAETYASRNNMSCFEISPLCNFNIRESFCELARMALHRNGMEH-------IWR 190

Human   189 GGGVTGWKSKCC 200
            ...|...:..||
  Fly   191 SNKVLSLQELCC 202

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RAB10	NP_057215.3	Rab8_Rab10_Rab13_like	7..173	CDD:206659	75/175 (43%)
		Switch 1. /evidence=ECO:0000250|UniProtKB:P62820	32..46		4/23 (17%)
		Switch 2. /evidence=ECO:0000250|UniProtKB:P62820	64..81		10/16 (63%)
Rab40	NP_727611.1	P-loop containing Nucleoside Triphosphate Hydrolases	6..265	CDD:476819	81/207 (39%)
		SOCS	192..234	CDD:470605	3/11 (27%)