Protein Alignment NPFFR2 and SIFaR

DIOPT Version :9

• Sequence 1: NP_001138228.1
• Gene: NPFFR2 / 10886
• HGNCID: 4525
• Length: 423
• Species: Homo sapiens
• Sequence 2: NP_001163674.1
• Gene: SIFaR / 42530
• FlyBaseID: FBgn0038880
• Length: 758
• Species: Drosophila melanogaster
• Alignment Length: 411
• Identity: 137/411 - (33%)
• Similarity: 226/411 - (54%)
• Gaps: 22/411 - (5%)

Human    23 NDTK---HHLYSDINITYVNYYLHQPQVAAIFIISYFLIFFLCMMGNTVVCFIVMRNKHMHTVTN 84
            ||:.   ..|...::..:...|.|...::.::.::|.::|.:.::||:.|..:|:|...|.||||
  Fly   180 NDSALRWEQLDGSVDFGFDPLYRHSLAMSMVYCVAYIVVFLVGLIGNSFVIAVVLRAPRMRTVTN 244

Human    85 LFILNLAISDLLVGIFCMPITLLDNIIAGWPFGNTMCKISGLVQGISVAASVFTLVAIAVDRFQC 149
            .||:||||:|:||.:||:|.||:.||...|..|..|||....:||:||||||::|:|:::|||..
  Fly   245 YFIVNLAIADILVIVFCLPATLIGNIFVPWMLGWLMCKFVPYIQGVSVAASVYSLIAVSLDRFIA 309

Human   150 VVYPFKPKLTIKTAFVIIMIIWVLAITIMSPSAVMLH-VQEEKYYRVRLNSQNKTSPVYWCREDW 213
            :.:|.| ::|.:.|.::|:.|||:|:....|..:... |..|:.:...|.|. .:.|.:.|:|.|
  Fly   310 IWWPLK-QMTKRRARIMIIGIWVIALVTTIPWLLFFDLVPAEEVFSDALVSA-YSQPQFLCQEVW 372

Human   214 PNQEMRKIYTTVLFANI---YLAPLSLIVIMYGRIGISLFRAAVPHTGRKNQEQWHVVSRK-KQK 274
            |......:|  .|.||:   ||.|:|||.:.|..|.|.:...::|  |.....|...:.:| |.|
  Fly   373 PPGTDGNLY--FLLANLVACYLLPMSLITLCYVLIWIKVSTRSIP--GESKDAQMDRMQQKSKVK 433

Human   275 IIKMLLIVALLFILSWLPLWTLMMLSDY-ADLSPNELQIINIYIYPFAHWLAFGNSSVNPIIYGF 338
            :||||:.|.:||:||||||:.:.....: :|:|..|.:|:. .:.|.|.||...||.:|||:|.
  Fly   434 VIKMLVAVVILFVLSWLPLYVIFARIKFGSDISQEEFEILK-KVMPVAQWLGSSNSCINPILYS- 496

Human   339 FNENFRRGFQEAFQLQLCQKRAKPMEAYALKAKSHVLINTSNQLVQESTFQNP--HGETLLYRKS 401
            .|:.:||||....:.:.|..|.:..:..|: |.|......|:...|.|:.::|  .|..:.|...
  Fly   497 VNKKYRRGFAAIIKSRSCCGRLRYYDNVAI-ASSTTSTRKSSHYHQNSSRKSPSSKGNAVSYIYE 560

Human   402 AEKPQQELVMEELKETTNSSE 422
            ....::..:|  ||:.:|.|:
  Fly   561 HNSLRRHNMM--LKQDSNLSQ 579

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NPFFR2	NP_001138228.1	7tm_4	56..>178	CDD:304433	54/121 (45%)
		7tm_1	65..336	CDD:278431	108/276 (39%)
SIFaR	NP_001163674.1	7tm_4	216..>443	CDD:304433	88/232 (38%)
		7tm_1	225..495	CDD:278431	108/276 (39%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165160516
Domainoid	1	1.000	183	1.000	Domainoid score	I3427
eggNOG	1	0.900	-	-		E33208_3BBX5
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H56982
Inparanoid	1	1.050	210	1.000	Inparanoid score	I3671
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm42029
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24241
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X258
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	9	8.890