Protein Alignment NPFFR2 and sNPF-R

DIOPT Version :10

• Sequence 1: NP_001138228.1
• Gene: NPFFR2 / 10886
• HGNCID: 4525
• Length: 423
• Species: Homo sapiens
• Sequence 2: NP_524176.1
• Gene: sNPF-R / 40195
• FlyBaseID: FBgn0036934
• Length: 600
• Species: Drosophila melanogaster
• Alignment Length: 363
• Identity: 105/363 - (28%)
• Similarity: 176/363 - (48%)
• Gaps: 70/363 - (19%)

Human    42 LHQPQVAAIFIISYFLIFFLCMMGNTVVCFIVMRNKHMHTVTNLFILNLAISDLLVGIFCMPITL 106
            :|...|...|.:.|..:|.|.:.||.:||::|:||:.|.||||:||.|||:||:|:.:..:|.|.
  Fly    57 IHNQFVQIFFYVLYATVFVLGVFGNVLVCYVVLRNRAMQTVTNIFITNLALSDILLCVLAVPFTP 121

Human   107 LDNIIAGWPFGNTMCKISGLVQGISVAASVFTLVAIAVDRFQCVVYPFKPKLTIKTAFVIIMIIW 171
            |...:..|.||.::|.:....||.|:..|..||.:||:||:..::|||.|::.:.|...||:.||
  Fly   122 LYTFMGRWAFGRSLCHLVSFAQGCSIYISTLTLTSIAIDRYFVIIYPFHPRMKLSTCIGIIVSIW 186

Human   172 VLAI------------------------------TIM-----------------SPSAVMLHVQ- 188
            |:|:                              |:|                 |.||...::|
  Fly   187 VIALLATVPYGMYMKMTNELVNGTQTGNETLVEATLMLNGSFVAQGSGFIEAPDSTSATQAYMQV 251

Human   189 --------EEKYYRVRLNSQNKTSPVYWCREDWPNQEMRKIYTTVLFANIYLAPLSLIVIMYGRI 245
                    |..|.||            :|.|:||:::.||::..:.....::.|..:|.|.|..|
  Fly   252 MTAGSTGPEMPYVRV------------YCEENWPSEQYRKVFGAITTTLQFVLPFFIISICYVWI 304

Human   246 GISLFRAAVPHTGRKNQEQWHVVSRKKQKIIKMLLIVALLFILSWLPLWTLMMLSDYADLSPNEL 310
            .:.|.:.|....|.|:..:......:|::..:||:.:..:|.|||||:..:.:..|:.|.| ||.
  Fly   305 SVKLNQRARAKPGSKSSRREEADRDRKKRTNRMLIAMVAVFGLSWLPINVVNIFDDFDDKS-NEW 368

Human   311 QIINIYIYPFAHWLAFGNSSVNPIIYGFFNENFRRGFQ 348
            :...::.: .||.:|..::..||.:|.:.|||||:.|:
  Fly   369 RFYILFFF-VAHSIAMSSTCYNPFLYAWLNENFRKEFK 405

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NPFFR2	NP_001138228.1	7tmA_NPFFR2	49..347	CDD:320646	102/353 (29%)
		TM helix 1	50..76	CDD:320646	9/25 (36%)
		TM helix 2	83..109	CDD:320646	13/25 (52%)
		TM helix 3	121..151	CDD:320646	11/29 (38%)
		TM helix 4	162..183	CDD:320646	11/67 (16%)
		TM helix 5	219..248	CDD:320646	7/28 (25%)
		TM helix 6	270..300	CDD:320646	9/29 (31%)
		TM helix 7	315..340	CDD:320646	6/24 (25%)
sNPF-R	NP_524176.1	7tmA_NPYR-like	64..404	CDD:320331	102/353 (29%)
		TM helix 1	65..91	CDD:320331	9/25 (36%)
		TM helix 2	98..123	CDD:320331	12/24 (50%)
		TM helix 3	136..166	CDD:320331	11/29 (38%)
		TM helix 4	177..198	CDD:320331	7/20 (35%)
		TM helix 5	278..307	CDD:320331	7/28 (25%)
		TM helix 6	329..359	CDD:320331	9/29 (31%)
		TM helix 7	372..397	CDD:320331	6/25 (24%)