Protein Alignment NPFFR2 and CCHa1-R

DIOPT Version :10

• Sequence 1: NP_001138228.1
• Gene: NPFFR2 / 10886
• HGNCID: 4525
• Length: 423
• Species: Homo sapiens
• Sequence 2: NP_611241.2
• Gene: CCHa1-R / 37004
• FlyBaseID: FBgn0050106
• Length: 499
• Species: Drosophila melanogaster
• Alignment Length: 443
• Identity: 110/443 - (24%)
• Similarity: 191/443 - (43%)
• Gaps: 88/443 - (19%)

Human     7 KW---DTNSSENWHPIWNVNDTKHHLYSDINITYVNY--YLHQPQVAAIFIISYFLIFFLCMMGN 66
            :|   ||.||||              :|::..|...|  |..:|:...:.|: :.|||.:.::||
  Fly    50 QWPLLDTGSSEN--------------FSELVTTETPYVPYGRRPETYIVPIL-FALIFVVGVLGN 99

Human    67 TVVCFIVMRNKHMHTVTNLFILNLAISDLLVGIFCMPITLLDNIIAGWPFGNTMCKISGLVQGIS 131
            ..:..:.:..:.|..|.|.:||:||::||||.|..:|:......:..||:|:.:|.:|..::.:|
  Fly   100 GTLIVVFLSVRQMRNVPNTYILSLALADLLVIITTVPLASTVYTVEYWPYGSFLCSLSEFMKDVS 164

Human   132 VAASVFTLVAIAVDRFQCVVYPFK-----------PKLTIKTAFVIIMIIWVLAITIMSPSAVML 185
            :..|||||.|::.||:..:|.|.:           .::|:.||    :.||:|||....|:.:..
  Fly   165 IGVSVFTLTALSGDRYFAIVDPLRKFHAHGGGRRATRMTLATA----VSIWLLAILCGLPALIGS 225

Human   186 HVQEEKYYRVRLNSQNKTSPV-YWCREDWPNQEMRKIYTTVLFANIYLAPLSLIVIMYGRIGISL 249
            :::       .|....|:..: |...|:| .....|....:.|...|..||.:|.:.|..|.:.|
  Fly   226 NLK-------HLGINEKSIVICYPYPEEW-GINYAKSMVLLHFLVYYAIPLVVIAVFYVLIALHL 282

Human   250 -FRAAVPH--TGRKNQEQWHVVSRKKQKIIKMLLIVALLFILSWLP-----LWTLMMLSDYADLS 306
             :.|:||.  .|...|      .|.::|:...:|...::|.:.:||     ||.....:...|.:
  Fly   283 MYSASVPGEIQGAVRQ------VRARRKVAVTVLAFVVIFGICFLPYHVFFLWFYFWPTAQDDYN 341

Human   307 P--NELQIINIYIYPFAHWLAFGNSSVNPIIYGFFNENFRRGFQEAFQLQLCQKRAKPMEAYALK 369
            .  :.|:|:       |:.::|.||..||:...|.:..||:.|......:....|.|       |
  Fly   342 AFWHVLRIV-------AYCMSFANSCANPVALYFVSGAFRKHFNRYLFCRGASGRRK-------K 392

Human   370 AKSHVLI----NTSNQLVQESTFQNPHGETLLYRKSAEKPQQELVMEELKETT 418
            ...|...    :||........||:.|.   .|:.:....:       |:|||
  Fly   393 RGQHDTFCMHRDTSLTSTASKRFQSRHS---CYQSTIRSCR-------LQETT 435

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NPFFR2	NP_001138228.1	7tmA_NPFFR2	49..347	CDD:320646	83/319 (26%)
		TM helix 1	50..76	CDD:320646	6/25 (24%)
		TM helix 2	83..109	CDD:320646	11/25 (44%)
		TM helix 3	121..151	CDD:320646	11/29 (38%)
		TM helix 4	162..183	CDD:320646	8/20 (40%)
		TM helix 5	219..248	CDD:320646	8/28 (29%)
		TM helix 6	270..300	CDD:320646	8/34 (24%)
		TM helix 7	315..340	CDD:320646	7/24 (29%)
CCHa1-R	NP_611241.2	7tmA_Bombesin_R-like	82..377	CDD:320593	83/320 (26%)
		TM helix 1	83..109	CDD:320593	6/26 (23%)
		TM helix 2	116..142	CDD:320593	11/25 (44%)
		TM helix 3	154..184	CDD:320593	11/29 (38%)
		TM helix 4	201..221	CDD:320593	8/23 (35%)
		TM helix 5	252..277	CDD:320593	7/24 (29%)
		TM helix 6	300..330	CDD:320593	7/29 (24%)
		TM helix 7	345..370	CDD:320593	9/31 (29%)