Protein Alignment NPFFR2 and CCKLR-17D1

DIOPT Version :10

• Sequence 1: NP_001138228.1
• Gene: NPFFR2 / 10886
• HGNCID: 4525
• Length: 423
• Species: Homo sapiens
• Sequence 2: NP_001097021.1
• Gene: CCKLR-17D1 / 32860
• FlyBaseID: FBgn0259231
• Length: 673
• Species: Drosophila melanogaster
• Alignment Length: 520
• Identity: 115/520 - (22%)
• Similarity: 197/520 - (37%)
• Gaps: 186/520 - (35%)

Human    50 IFIISYFLIFFLC-MMGNTVVCFIVMRNKHMHTVTNLFILNLAISDLLVGIFCMPITLLDNIIAG 113
            |:::..:....|| ::||.:|...:::|:.|.|:||:|:|||||||:|:|:||||:||:..::..
  Fly   176 IWVVPCYSAILLCAVVGNLLVVLTLVQNRRMRTITNVFLLNLAISDILLGVFCMPVTLVGTLLRH 240

Human   114 WPFGNTMCKISGLVQGISVAASVFTLVAIAVDRFQCVVYPFKPKL--TIKTAFVIIMIIWVLAIT 176
            :.||..:||:....|..|||.|.:|||||:.:|:..:.:|.:.:.  ||..|..||.|||:.::.
  Fly   241 FIFGELLCKLIQFAQAASVAVSSWTLVAISCERYYAICHPLRSRTWQTINHANKIIAIIWLGSLV 305

Human   177 IMSPSAVMLHVQEEKYYRVRLNSQNKTSPVYWCREDWPNQEMRKIYTTVLFANIYLAPLSLIVIM 241
            .|:|.|....:.......:|.           |||.||...:.......||.::.|..|.|:.:.
  Fly   306 CMTPIAAFSQLMPTSRPGLRK-----------CREQWPADSLNYERAYNLFLDLALLVLPLLALS 359

Human   242 ----------------------------------------------------------------- 241
                                                                             
  Fly   360 FTYLFITRTLYVSMRNERAMNFGSSGPEVTTSSSAAVAEAGSQRRANGSHCQSLDTIVPHQHNPH 424

Human   242 ------------YGRIGIS--LFRAAVPHTGRKN------------------------------- 261
                        ||..|..  |.....|..||::
  Fly   425 QQHHHHSQYYYDYGHCGSKRRLISGGGPCEGRRHLYCMRSASVKSLRHQQINGGGGTLSGTGAGN 489

Human   262 ----------------QEQWHV---VSRK--------------------------KQKIIKMLLI 281
                            |:|.:|   .||:                          |::::|||.:
  Fly   490 GECCSRVHRMRQQMQLQQQGYVSDNESRRKSLSQPSLRITEAGLRRSNETKSLESKKRVVKMLFV 554

Human   282 VALLFILSWLPLW---TLMMLSDYADLSPNELQIINIYIYPFAHWLAFGNSSVNPIIYGFFNENF 343
            :.|.|.:.|.||:   |:.||     |.|...:.:......|...||:.:|..|||.|.|.|.:|
  Fly   555 LVLEFFICWTPLYVINTMTML-----LGPTVYEYVGYTSISFLQLLAYSSSCCNPITYCFMNASF 614

Human   344 RRGFQEAFQ-LQLCQKRAKPMEAYALKAKSHVLINTS-NQLVQESTFQNPHGETLLYRKSAEKPQ 406
            ||.|.:.|: :::|::...|...:..::|:...::.: |.:...::..:.|  |:|     |.|:
  Fly   615 RRAFVDTFKGMRVCERLCAPCCFWRRRSKNETNLSVAGNSIALANSVMSSH--TIL-----ESPR 672

Human   407  406
              Fly   673  672

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NPFFR2	NP_001138228.1	7tmA_NPFFR2	49..347	CDD:320646	104/457 (23%)
		TM helix 1	50..76	CDD:320646	6/26 (23%)
		TM helix 2	83..109	CDD:320646	18/25 (72%)
		TM helix 3	121..151	CDD:320646	13/29 (45%)
		TM helix 4	162..183	CDD:320646	8/20 (40%)
		TM helix 5	219..248	CDD:320646	8/105 (8%)
		TM helix 6	270..300	CDD:320646	12/58 (21%)
		TM helix 7	315..340	CDD:320646	9/24 (38%)
CCKLR-17D1	NP_001097021.1	7tm_GPCRs	177..618	CDD:475119	103/456 (23%)
		TM helix 1	178..202	CDD:410628	5/23 (22%)
		TM helix 2	211..233	CDD:410628	15/21 (71%)
		TM helix 3	249..271	CDD:410628	11/21 (52%)
		TM helix 4	294..310	CDD:410628	6/15 (40%)
		TM helix 5	340..363	CDD:410628	5/22 (23%)
		TM helix 6	549..571	CDD:410628	8/21 (38%)
		TM helix 7	586..611	CDD:410628	9/24 (38%)