DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ACTL7B and Actl7b

DIOPT Version :9

Sequence 1:	NP_006677.1	Gene:	ACTL7B / 10880	HGNCID:	162	Length:	415	Species:	Homo sapiens
Sequence 2:	NP_001020588.1	Gene:	Actl7b / 313183	RGDID:	1305655	Length:	417	Species:	Rattus norvegicus

Alignment Length:	418	Identity:	364/418 - (87%)
Similarity:	384/418 - (91%)	Gaps:	4/418 - (0%)

- Green bases have known domain annotations that are detailed below.

Human     1 MATRN--SPMPLGTAQGDPGEAGTRPGPDASLRDTGAATQLKMKPRKVHKIKAVIIDLGSQYCKC 63
            |||:|  ||.|:||||||||||||.|.|:|.:|||| :||||.||:|:.||||::||||||||||
  Rat     1 MATKNNPSPKPMGTAQGDPGEAGTLPAPEAGIRDTG-STQLKAKPKKIRKIKALVIDLGSQYCKC 64

Human    64 GYAGEPRPTYFISSTVGKRCPE-AADAGDTRKWTLVGHELLNTEAPLKLVNPLKHGIVVDWDCVQ 127
            |||||||||||||||||||..| |||||||.|.|.|||||||.||.||||||||||:||||||:|
  Rat    65 GYAGEPRPTYFISSTVGKRSAEMAADAGDTFKETYVGHELLNMEASLKLVNPLKHGVVVDWDCIQ 129

Human   128 DIWEYIFRTAMKILPEEHAVLVSDPPLSPSSNREKYAELMFETFGIPAMHVTSQSLLSIYSYGKT 192
            :||||||.|||||||||||||||||||||:||||||||||||||||||||||||:||||||||||
  Rat   130 NIWEYIFHTAMKILPEEHAVLVSDPPLSPTSNREKYAELMFETFGIPAMHVTSQALLSIYSYGKT 194

Human   193 SGLVVESGHGVSHVVPISEGDVLPGLTSRADYAGGDLTNYLMQLLNEAGHAFTDDHLHIIEHIKK 257
            |||||||||||||||||||||:||||.||.||||.|||||||||||||||.|:||||||||||||
  Rat   195 SGLVVESGHGVSHVVPISEGDLLPGLPSRVDYAGCDLTNYLMQLLNEAGHKFSDDHLHIIEHIKK 259

Human   258 KCCYAAFLPEEELGLVPEELRVDYELPDGKLITIGQERFRCSEMLFQPSLAGSTQPGLPELTAAC 322
            ||||||.|||||:.|..:||.|||||||||:|||||||||||||||:|||.||||||||||||.|
  Rat   260 KCCYAALLPEEEMSLGLDELHVDYELPDGKVITIGQERFRCSEMLFKPSLVGSTQPGLPELTATC 324

Human   323 LGRCQDTGFKEEMAANVLLCGGCTMLDGFPERFQRELSLLCPGDSPAVAAAPERKTSVWTGGSIL 387
            |.|||.||||||||||||||||||||||||||||||||||||||||.||||||||||||||||||
  Rat   325 LDRCQGTGFKEEMAANVLLCGGCTMLDGFPERFQRELSLLCPGDSPTVAAAPERKTSVWTGGSIL 389

Human   388 ASLQAFQQLWVSKEEFEERGSVAIYSKC 415
            ||||||||||||||||||||..||||||
  Rat   390 ASLQAFQQLWVSKEEFEERGCAAIYSKC 417

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ACTL7B	NP_006677.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..31		22/31 (71%)
ACTL7B	NP_006677.1	NBD_sugar-kinase_HSP70_actin	51..415	CDD:327376	326/364 (90%)
Actl7b	NP_001020588.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..39		26/38 (68%)
Actl7b	NP_001020588.1	ACTIN	51..417	CDD:214592	327/365 (90%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C83680952
Domainoid	1	1.000	677	1.000	Domainoid score	I3794
eggNOG	1	0.900	-	-		E1_COG5277
HGNC	1	1.500	-	-
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H21330
Inparanoid	1	1.050	740	1.000	Inparanoid score	I8273
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG41974
OrthoDB	1	1.010	-	-		D104008at40674
OrthoFinder	1	1.000	-	-		FOG0016303
OrthoInspector	1	1.000	-	-		oto129572
orthoMCL	1	0.900	-	-		OOG6_128355
Panther	1	1.100	-	-	LDO	PTHR11937
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X13246
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	18	18.270