DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SLC26A1 and CG5404

DIOPT Version :9

Sequence 1:	NP_071325.2	Gene:	SLC26A1 / 10861	HGNCID:	10993	Length:	701	Species:	Homo sapiens
Sequence 2:	NP_650482.1	Gene:	CG5404 / 41901	FlyBaseID:	FBgn0038354	Length:	627	Species:	Drosophila melanogaster

Alignment Length:	510	Identity:	126/510 - (24%)
Similarity:	225/510 - (44%)	Gaps:	86/510 - (16%)

- Green bases have known domain annotations that are detailed below.

Human    54 LPATRWLRQYRPREYLAGDVMSGLVIGIILVPQAIAYSLLAGLQPIYSLYTSFFANLIYFLMGTS 118
            :|..:||..| ..|:...|.::|:.:|:.::|:::|.:|||||...|.|.::|...|||.:.|:.
  Fly    49 VPVFQWLPLY-STEWGIDDFIAGITLGLTIIPESMACALLAGLPARYGLCSAFIGPLIYMVFGSI 112

Human   119 RHVSVGIFSLLCLMVGQVVDRELQLAGFDPSQDGLQPGANSSTLNGSAAMLDCGRDCYAIRVATA 183
            ..|.:|..||:.|:                                 :.....||   .|..|..
  Fly   113 DKVIIGPTSLVALV---------------------------------SVQFTVGR---PIEFAFL 141

Human   184 LTLMTGLYQVLMGVLRLGFVSAYLSQPLLDGFAMGASVTILTSQLKHLLGVRIPRHQGPGMVVLT 248
            ||.::|:.|::||.:|:||:..::|.|::..|:...::.::.||||.|||::.       :|.
  Fly   142 LTFLSGIVQIIMGTMRMGFIFEFISMPVIKAFSSATAILVIESQLKVLLGIKY-------LVA-- 197

Human   249 WLSLLRGAG-------QANVCDVVTSTVCLAVLLAAKELSDRYRHR------LRV-----PLPTE 295
              .|:...|       ::|:.|::.. ||..|.|...||.||..:.      ||:     .....
  Fly   198 --GLMNSVGMLSSRIEESNMADLIMG-VCAIVFLLLLELLDRVANNEKRNKILRIFCRYLSTSRN 259

Human   296 LLVIVVATLVSHF-----GQLHKRFGSSVAGDIPTGFMPPQVPEP--------RLMQRVALDAVA 347
            .|::::|.:||..     ||:......:....:|...:|....|.        .:::.:.:..:.
  Fly   260 TLIVLIAAIVSFIWIQKCGQVPYALSKNALSTLPNFTVPSFHIETAERNYSIWEVLKELNIGIIV 324

Human   348 LALVAAAFSISLAEMFARSHGYSVRANQELLAVGCCNVLPAFLHCFATSAALAKSLVKTATGCRT 412
            :.:|....:||:.::..:.   .|..|||||.||.||:..:.:....:|.|..:..:.||.|.||
  Fly   325 IPIVGILTNISIGKLTPKG---LVDTNQELLTVGLCNMFGSCVQAMPSSGAFTRYAISTACGLRT 386

Human   413 QLSSVVSATVVLLVLLALAPLFHDLQRSVLACVIVVSLRGALRKVWDLP-RLWRMSPADALVWAG 476
            .::::....:|||.|..|:|.|:.:..:.||.:::.|:...|.  :.|| ||||.|..|...|..
  Fly   387 PMANLYLGIIVLLALSYLSPYFNYIPEATLAAILICSIFTLLD--FKLPMRLWRDSKRDFATWLL 449

Human   477 TAATCMLVSTEAGLLAGVILSLLSLAGRTQRPRTALLARIGDTAFYEDATEFEGL 531
            .....:|...|.||...::::.|.|.....||...:.....|...|...|...|:
  Fly   450 CFCVSVLFGVEVGLFVSIVVTALHLLFLWARPEIRVKIEQLDEMQYIRVTPSNGI 504

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SLC26A1	NP_071325.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..20
		sulP	55..683	CDD:273284	126/509 (25%)
		STAS_SulP_like_sulfate_transporter	528..669	CDD:132913	1/4 (25%)
CG5404	NP_650482.1	sulP	50..557	CDD:273284	126/509 (25%)
CG5404	NP_650482.1	STAS_SulP_like_sulfate_transporter	498..>554	CDD:132913	2/7 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0659
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000041
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X49
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.810