Protein Alignment SLC26A1 and Prestin

DIOPT Version :10

• Sequence 1: NP_071325.2
• Gene: SLC26A1 / 10861
• HGNCID: 10993
• Length: 701
• Species: Homo sapiens
• Sequence 2: NP_649024.1
• Gene: Prestin / 39996
• FlyBaseID: FBgn0036770
• Length: 742
• Species: Drosophila melanogaster
• Alignment Length: 759
• Identity: 230/759 - (30%)
• Similarity: 374/759 - (49%)
• Gaps: 98/759 - (12%)

Human     3 ESPE--PLQQGR-----GPVPVR---------------------------RQRPAPRGLREMLKA 33
            ||||  ||....     |.||.:                           |.:..|..||
  Fly     6 ESPETKPLNNNNTNGNGGSVPSKPKIQPKYSIHRDVLTHEVVIKQTGYAARDKSIPSSLR----- 65

Human    34 RLWCSCSCSVLCVRALVQDLLPATRWLRQYRPREYLAGDVMSGLVIGIILVPQAIAYSLLAGLQP 98
            ..|.|.:     ..||...::|..:||.||.||..|.||:::|..:.|:.:|..:||.:|||:..
  Fly    66 NCWRSWN-----FFALFTGVIPILQWLPQYSPRRDLPGDIIAGFTVAIMNIPHGMAYGILAGVSA 125

Human    99 IYSLYTSFFANLIYFLMGTSRHVSVGIFSLLCLMVGQVVD---------RELQLAGFDPSQDGLQ 154
            ...||.:.|..|.|..:|||:|:|:|.|::..:|..:|||         :.|.:..|....:|..
  Fly   126 GNGLYMAVFPVLAYMFLGTSKHISIGTFAVASMMTAKVVDTYANVDDHHQILPINAFGLQSNGTA 190

Human   155 PGA-----NSSTLNGSAA--------MLDCGRDC---YAIRVATALTLMTGLYQVLMGVLRLGFV 203
            ..:     |||.|..|.:        :|:...:.   ..|.|||:|.|..|:..:||..||||.:
  Fly   191 TASPLLLINSSALADSVSSTTISPFQLLNSTLNADPITKIEVATSLALTVGIVNLLMAFLRLGTL 255

Human   204 SAYLSQPLLDGFAMGASVTILTSQLKHLLGVRIPRHQGPGMVVLTWLSLLRGAGQANVCDVVTST 268
            |:.||:||::||...|:..::|:|||.:||:.:|||:|...::.|.:.:::|..|.|   :|...
  Fly   256 SSLLSEPLVNGFTTAAACHVVTAQLKDVLGISVPRHKGAFKIIYTVIDVIKGVPQTN---LVNFG 317

Human   269 VCLAV----LLAAKELSDRYRHRLRVPLPTELLVIVVATLVSHFGQLHKRFGSSVAGDIPTGFMP 329
            .|:||    ::..:.|..|...:.|.|||.||::::..||:|.:..|:..:..:..|.||:|...
  Fly   318 FCMAVIAFMMICNEILKPRLSKKCRFPLPAELIMVIGGTLISKWFNLYVDYNVNPVGKIPSGLPE 382

Human   330 PQVPEPRLMQRVALDAVALALVAAAFSISLAEMFARSHGYSVRANQELLAVGCCNVLPAFLHCFA 394
            |.:|...|:.:||:|::|:|:|..:..:|:...||:.|||.||.||||.|:|..|::.....|..
  Fly   383 PVLPRLDLVPKVAVDSIAIAIVTYSIIMSMGLTFAKKHGYEVRPNQELFAMGIGNMVGGCFSCIP 447

Human   395 TSAALAKSLVKTATGCRTQLSSVVSATVVLLVLLALAPLFHDLQRSVLACVIVVSLRGALRKVWD 459
            .:.:|::|:::..||..:|::|:|||::|::.|:.:.|.|..|.|.|||.||:|:|:....:..:
  Fly   448 MACSLSRSVIQDQTGGVSQIASLVSASLVVVTLMWIGPFFSSLPRCVLAGVIIVALKPMFMQAKE 512

Human   460 LPRLWRMSPADALVWAGTAATCMLVSTEAGLLAGVILSLLSLAGRTQRPRTALLARIGDT-AFYE 523
            |.:..:....:...|..|....:::..:.|||.|:.:|||:|..:..:|.:.||..:.:. ..|.
  Fly   513 LKKFSKQGKLEMFTWISTFLCVVIIDIDIGLLIGICISLLALYIKGLKPYSCLLGYMPEAPGIYM 577

Human   524 DATEFEGLVPEPGVRVFRFGGPLYYANKDFFLQSLYSLTGLDAGCMAARRKEGGSETGVGEGGPA 588
            |..:....:..|.||:||:.|.|.:|...||.::||...|||   .....|...|.:    ..|:
  Fly   578 DLNQHRNAMQVPEVRIFRYSGSLNFATSLFFRRALYEAVGLD---KIPLTKVSSSNS----NSPS 635

Human   589 QG--EDLGPVSTRAA------LVPAAAGFHTVVIDCAPLLFLDAAGVSTLQDLRRDYGALGISLL 645
            :|  ....|||....      |...:..|..:|:|.:.|..:|.||..||.||.::....|..||
  Fly   636 KGSKSSYSPVSQNGGKAINGKLEETSGAFKVLVLDFSMLGHIDVAGCRTLTDLSKELKVRGARLL 700

Human   646 LACCSPPVRDILSRGGFLGEGPGDTAEEEQLFLSVHDAVQTARA 689
            ||.....|.|.|.....|.|||      .::|.::||.|:.|.|
  Fly   701 LASPVDRVYDTLVHSMALSEGP------FEIFPTLHDCVEYANA 738

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC26A1	NP_071325.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..20		9/50 (18%)
		sulP	55..683	CDD:273284	209/665 (31%)
Prestin	NP_649024.1	PRK11660	82..731	CDD:481320	208/664 (31%)