DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CYP46A1 and Cyp4e1

DIOPT Version :9

Sequence 1:	NP_006659.1	Gene:	CYP46A1 / 10858	HGNCID:	2641	Length:	500	Species:	Homo sapiens
Sequence 2:	NP_524771.1	Gene:	Cyp4e1 / 44632	FlyBaseID:	FBgn0015034	Length:	531	Species:	Drosophila melanogaster

Alignment Length:	495	Identity:	137/495 - (27%)
Similarity:	223/495 - (45%)	Gaps:	79/495 - (15%)

- Green bases have known domain annotations that are detailed below.

Human    39 PSFL--------LGHLPCFWKKDEVGGRVLQDVFLDWAKKYG-PVVRVNVFHKTSVIVTSPESVK 94
            ||.|        :|:.|     .|:..|     |..|..:|| ...|..:.:.::::||:|:.::
  Fly    36 PSMLPLVGNAHQMGNTP-----TEILNR-----FFGWWHEYGKDNFRYWIGYYSNIMVTNPKYME 90

Human    95 KFLMSTKYNKDSKMYRALQTVFGERLFGQGLVSECNYERWHKQRRVIDLAFSRSSLVSLMETFNE 159
            ..|.|......|.:|.....     ..|.||::... .:|||.|::|..||..:.|....|..||
  Fly    91 FILSSQTLISKSDVYDLTHP-----WLGLGLLTSTG-SKWHKHRKMITPAFHFNILQDFHEVMNE 149

Human   160 KAEQLVEILEAKADGQTPVSMQDMLTYTAMDILAKAAFGMETSMLLGAQKPLSQAVKLMLEGITA 224
            .:.:.::.|:..|||......|:...|..:|::...|.|:.    :.|.:..|.:|....:.||.
  Fly   150 NSTKFIDQLKKVADGGNIFDFQEEAHYLTLDVICDTAMGVS----INAMENRSSSVVQAFKDITY 210

Human   225 SRNTLAKFLPGKRK--------QLREVRESIRFLRQVGRDWVQRRREALKRGEEVPADILTQILK 281
            :....| |.|.||.        :..|..::::.|:....:.:.:|.|..|.|.||.       :|
  Fly   211 TIKMRA-FSPWKRNKYLFHFAPEYPEYSKTLKTLQDFTNEIIAKRIEVRKSGLEVG-------IK 267

Human   282 AEEGAQDDEGLLDNFV-------------------TFFIAGHETSANHLAFTVMELSRQPEIVAR 327
            |:|.::.....||..:                   ||...||:|:.:.:.|.|..|||.|:...:
  Fly   268 ADEFSRKKMAFLDTLLSSKVDGRPLTSQELYEEVSTFMFEGHDTTTSGVGFAVYLLSRHPDEQEK 332

Human   328 LQAEVDEVIGSK---RYLDFEDLGRLQYLSQVLKESLRLYPPAWGTFRLLEEETLIDGVRVPGNT 389
            |..|..:|:|:.   |...|:::..:::|...:||:.||||......|..|::.:|||..||..|
  Fly   333 LFNEQCDVMGASGLGRDATFQEISTMKHLDLFIKEAQRLYPSVPFIGRFTEKDYVIDGDIVPKGT 397

Human   390 PLLFSTYVMGRMDTYFEDPLTFNPDRFGPGAPKPRFTYFPFSLGHRSCIGQQFAQMEVKVVMAKL 454
            .|.....::|..|..|:||..|.|:||....|.| |.|.|||.|.|:||||:||.:|:|.|::|:
  Fly   398 TLNLGLLMLGYNDRVFKDPHKFQPERFDREKPGP-FEYVPFSAGPRNCIGQKFALLEIKTVVSKI 461

Human   455 LQRLEFRLVPGQRFGLQEQATLKPLDPVLCTLRPRGWQPA 494
            ::  .|.::|    .|.|   |...|..:.|  ..|.|||
  Fly   462 IR--NFEVLP----ALDE---LVSKDGYIST--TLGLQPA 490

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CYP46A1	NP_006659.1	p450	34..466	CDD:365848	128/465 (28%)
Cyp4e1	NP_524771.1	p450	34..469	CDD:278495	127/463 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810