Protein Alignment CYP46A1 and Cyp313a1

DIOPT Version :9

• Sequence 1: NP_006659.1
• Gene: CYP46A1 / 10858
• HGNCID: 2641
• Length: 500
• Species: Homo sapiens
• Sequence 2: NP_650368.1
• Gene: Cyp313a1 / 41759
• FlyBaseID: FBgn0038236
• Length: 492
• Species: Drosophila melanogaster
• Alignment Length: 473
• Identity: 102/473 - (21%)
• Similarity: 189/473 - (39%)
• Gaps: 96/473 - (20%)

Human    33 IPGPPRPSFLLGHLPCFWKKDEVGGRVLQDVF---------LDWAKKYGPVVRVNVFHKTSVIVT 88
            ||||      :| ||       :.|..|:::.         ..:..|||..:...:.....::..
  Fly    32 IPGP------IG-LP-------ILGSSLENIITYKRKLSFRTKYLNKYGSTILTWMGPVPFIVTR 82

Human    89 SPESVKKFLMSTK-YNKDSKMYRALQTVFGERLFGQGLVSECNYERWHKQRRVIDLAFSRSSLVS 152
            .|:.|:....|.. :||...:..|:.:..|..|.|:      ....|..:|:..:.:|.:..|:|
  Fly    83 DPKVVEDIFSSPDCHNKSQHIVNAITSCMGNGLLGK------QDPHWLDRRKHFNPSFKQDLLLS 141

Human   153 LMETFNEKAEQLVEILEAKAD-GQTPVSMQDMLTYTAMDILAKAAFGMET---------SMLLGA 207
            ....|:.:.:.|:.:|:...| |:..| :.:||.: :..|.|:...|.|.         |::...
  Fly   142 FFHIFDAETKVLMNLLDTYVDKGEIDV-VPEMLRW-SFKIAAQTTMGSEVKHDEHFKNGSLVESF 204

Human   208 QKPLSQAVKLMLEGITASR----------------NTLAKFLPGKRKQLREVRESIRFLRQVGRD 256
            :..:|.:...:|..:..:|                :.:.|.|.      ..|.:.:..|.:...|
  Fly   205 ESLISHSTLNILMPLVQNRMISKICGYDKLRADNFSRIQKMLD------NVVNKKVNPLPKTDSD 263

Human   257 -----WVQRRREALKRGEEVPADILTQILKAEEGAQDDEGLLDNFVTFFIAGHETSANHLAFTVM 316
                 .:.|..|..::|     ||....:|:|            ......||::|||..:...:.
  Fly   264 PESNIVINRAMELYRKG-----DITYMDVKSE------------CCIMIAAGYDTSALTVYHALF 311

Human   317 ELSRQPEIVARLQAEVDEVIGSKRY--LDFEDLGRLQYLSQVLKESLRLYPPAWGTFRLLEEET- 378
            .|:..||....:..|::.|.....:  :.:.|:.:|.||.:|:||:|||.|....|.|..:.:.
  Fly   312 LLANHPEHQEAVFEELNGVFPDAGHFGITYPDMQKLDYLERVIKETLRLIPAIPITARETKNDVR 376

Human   379 LIDGVRVPGNTPL---LFSTYVMGRMDTYFEDPLTFNPDRF--GPGAPKPRFTYFPFSLGHRSCI 438
            |.:||.:|....:   :|.|:  ...:.:..|...||||.|  .....|..:.|.||:.|.|:||
  Fly   377 LSNGVLIPKGVVIGIDMFHTH--RNPEVWGPDADNFNPDNFLAENMEQKHPYAYIPFARGKRNCI 439

Human   439 GQQFAQMEVKVVMAKLLQ 456
            |.::|.|..|..:.::|:
  Fly   440 GSKYAMMSSKFALCRILR 457

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CYP46A1	NP_006659.1	p450	34..466	CDD:365848	101/472 (21%)
Cyp313a1	NP_650368.1	p450	33..463	CDD:299894	101/472 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D825914at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920