Protein Alignment CYP46A1 and Cyp313a4

DIOPT Version :9

• Sequence 1: NP_006659.1
• Gene: CYP46A1 / 10858
• HGNCID: 2641
• Length: 500
• Species: Homo sapiens
• Sequence 2: NP_650224.3
• Gene: Cyp313a4 / 41563
• FlyBaseID: FBgn0038076
• Length: 494
• Species: Drosophila melanogaster
• Alignment Length: 508
• Identity: 123/508 - (24%)
• Similarity: 206/508 - (40%)
• Gaps: 97/508 - (19%)

Human    33 IPGP---PRPSFLLGHLPCFWKKDEVGGRVLQDVFLDWAKKYGPVVRVNVFHKTSVIVTSPESVK 94
            ||||   |    :||......:::::....  ..|||   |:||.:...:.....:||:.|:.|:
  Fly    32 IPGPLGYP----ILGMAHWLMRREDILNAF--GCFLD---KHGPTIFSWLGPIPFMIVSDPQVVQ 87

Human    95 KFLMSTKYNKDSKMYRALQTVFGERLFGQGLVSECNYERWHKQRRVIDLAFSRSSLVSLMETFNE 159
            ....|........:|:|:....|..||      .....||...|::::.||....|:|.:..||.
  Fly    88 DIFTSPHCVNKGIIYKAVDDGAGVGLF------SLKDPRWSIHRKLLNPAFGHKVLLSFLPIFNR 146

Human   160 KAEQLVEILE-AKADGQTPVSMQDMLTYTAMDILAKAAFGMETSMLLGA---------QKPLSQA 214
            :...|::.|| .:.||:     :|::     .:|.....|:.|...:|:         ...|...
  Fly   147 ETALLLDQLEPLQDDGE-----KDLI-----PLLQSFTLGIATQTTMGSDVKDEESFRSNSLLGR 201

Human   215 VKLMLEGITAS------RNTLAKFLPGKRKQLREVRESIR-FLRQVGRDWVQRRREALKRGEEVP 272
            .:.:||.:|..      .:...:.|.||.....:.:..|| |:|::    ::|:
  Fly   202 YQCILETMTDMCFSPWLNSRFCRQLAGKESHYYQAKTEIRQFIRKI----IERK----------- 251

Human   273 ADILTQILKAEEGA-----QDDEGLLDNFVT-------------------FFIAGHETSANHLAF 313
                  :.:.|.||     .:|:.|..|.||                   ......||:||.:.:
  Fly   252 ------LAEDEMGALPSIQSNDKNLFLNLVTDLMRRGVFTLKNVEDESNIIVFGAFETTANAVYY 310

Human   314 TVMELSRQPEIVARLQAEVDEVIGSKRYLD--FEDLGRLQYLSQVLKESLRLYPPAWGTFRLLEE 376
            |:|.|:..||...|...|:..:..:....|  :.|..::.||..:|.||:|:.||.....|...:
  Fly   311 TLMLLAMFPEYQERAFEEIKTIFPNTGDFDVSYADTQQMVYLDLILNESMRVIPPVPVVSRQTSQ 375

Human   377 E-TLIDGVRVPGNTPLLFSTYVMGRMDTYF-EDPLTFNPDRFGPG--APKPRFTYFPFSLGHRSC 437
            : .|.:|:.||....:....|.|.|....: .|..|||||.|.|.  ..|..:.|.||:.|.|:|
  Fly   376 DLKLSNGIVVPKGVQIAIDIYHMHRSKKIWGPDAETFNPDHFLPHNIQDKHPYAYIPFTKGIRNC 440

Human   438 IGQQFAQMEVKVVMAKLLQRLEFRL-VPGQRFGLQEQATLKPLDPVLCTLRPR 489
            ||.::|.:..||.:||||:...|:. .|.:.....|..|:|.....|..|:.|
  Fly   441 IGWRYALISAKVTLAKLLRNYRFKTSFPFENLYFVEDITMKLKSVPLLELQKR 493

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CYP46A1	NP_006659.1	p450	34..466	CDD:365848	116/482 (24%)
Cyp313a4	NP_650224.3	p450	33..465	CDD:299894	115/477 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D825914at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920