Protein Alignment CYP46A1 and Cyp313a5

DIOPT Version :9

• Sequence 1: NP_006659.1
• Gene: CYP46A1 / 10858
• HGNCID: 2641
• Length: 500
• Species: Homo sapiens
• Sequence 2: NP_650168.1
• Gene: Cyp313a5 / 41486
• FlyBaseID: FBgn0038005
• Length: 487
• Species: Drosophila melanogaster
• Alignment Length: 511
• Identity: 120/511 - (23%)
• Similarity: 219/511 - (42%)
• Gaps: 71/511 - (13%)

Human     7 LLGSAVLLAFG--LCCTFVHRARSRY---EHIPGPPRPSFLLGHLPCFWKKDEVGGRVLQDVFLD 66
            :|...:..||.  ||..|:...|..|   ..:|||....|:.........|.::..|.:  :|
  Fly     1 MLTLQIFEAFAIILCVYFLWSRRRFYIMMLKLPGPMGFPFIGLAFEYIRLKRKIRLRTI--LF-- 61

Human    67 WAKKYGPVVRVNVFHKTSVIVT-SPESVKKFLMSTK-YNKDSKMYRALQTVFGERLFGQGLVSEC 129
              |.||..| :.....|.|:|| .|:.::....|.. .|:.|.:.:|:.:     ..|.||::..
  Fly    62 --KIYGKTV-LTWIGLTPVLVTCEPKILEDIFTSPNCSNRSSVVDKAISS-----CLGLGLLTLK 118

Human   130 NYERWHKQRRVIDLAFSRSSLVSLMETFNEKAEQLVEILEAKADGQTPVSMQDMLTYTAMDILAK 194
            | ..|:::|:::..:|..::::|.:...|.:|..||.:|....|| ..:::...|...:..|.|:
  Fly   119 N-NHWNERRKLLLPSFKNNAVLSFVPVLNNEANFLVTLLAEFVDG-GDINLLPELNKWSFKIAAQ 181

Human   195 AAFGME--------TSMLLGAQKPLSQAVKLMLEGITAS--RNT-LAKFLPGKRKQLREVRESIR 248
            ...|.|        ...||.:.|.|:..:.:   |:...  ||. |.|....::::|....:|..
  Fly   182 ITMGDEVRNQANYQNGNLLESYKALNNLIPI---GVVMPWLRNKYLGKLFSYEKRRLEAATQSNA 243

Human   249 FLRQVGRDWVQRRREALKRGEEVPA--DILTQILKAEEGAQDDEGLLDNFVTFFIAGHETSANHL 311
            |:    :|.:.::..:.....| ||  |.:..:::..|.:.||  ::..|.....|..:|.:..:
  Fly   244 FI----KDIIDKKLSSTDNSSE-PALIDRILNLVRIGELSYDD--VMGEFSNIIFAASDTLSITV 301

Human   312 AFTVMELSRQPEIVARLQAEVDEVIGSKRYLDFE----DLGRLQYLSQVLKESLRLYPPAWGTFR 372
            ...::.::..|:....:..|:.||..|..  :||    ||.:|..|.:||.|::||.|    ...
  Fly   302 NNVLILMAMFPKYQDNVFEELAEVFPSGG--EFEASHADLEKLVKLDRVLHETMRLIP----AVP 360

Human   373 LLEEET-----LIDGVRVPGNTPLLFSTYVMGR-MDTYFEDPLTFNPDRFGP--GAPKPRFTYFP 429
            ||..:|     |.:|..:|....|:...:...| .|.:......||||.|.|  ...:|.::|.|
  Fly   361 LLIRQTSHSIQLSNGFYIPEGVTLMIDIFHTHRNKDIWGPQANAFNPDNFLPENKRARPPYSYLP 425

Human   430 FSLGHRSCIGQQFAQMEVKVVMAKLLQRL---------EFRLVPGQRFGLQEQATL 476
            ||.|.::|:|.:.:.:..|:.:||:|:..         :.|.:......|.||..|
  Fly   426 FSKGKKTCLGWKLSLISAKLALAKILRNYMLSTTFLYKDLRFIDNTTMKLAEQPLL 481

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CYP46A1	NP_006659.1	p450	34..466	CDD:365848	108/467 (23%)
Cyp313a5	NP_650168.1	p450	33..458	CDD:299894	107/454 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D825914at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.010