Protein Alignment CYP46A1 and Cyp312a1

DIOPT Version :9

• Sequence 1: NP_006659.1
• Gene: CYP46A1 / 10858
• HGNCID: 2641
• Length: 500
• Species: Homo sapiens
• Sequence 2: NP_001262008.1
• Gene: Cyp312a1 / 40005
• FlyBaseID: FBgn0036778
• Length: 510
• Species: Drosophila melanogaster
• Alignment Length: 537
• Identity: 127/537 - (23%)
• Similarity: 224/537 - (41%)
• Gaps: 95/537 - (17%)

Human     4 GLLLLGSAVLLAFGLCCTFVHRARSRYEHI----PGPPRPSFLLGHLPCFWKKDEVGGRVLQDVF 64
            |||      |||..|...:|...:||.:.:    |.||...| :|||           .:|
  Fly     7 GLL------LLALSLYLLYVFERQSRIDRLTHKWPAPPALPF-IGHL-----------HIL---- 49

Human    65 LDWAKKYGP------VVRVNV-FH----------KTSVIVTSPESVKKFLMSTKYNKDSKMYRAL 112
               ||..||      ...:|. .|          |..::..:|:.::....:.:..:.:..||..
  Fly    50 ---AKLVGPHPLRRATEMINEHLHDHRAKLWMGTKLYLVDCNPKDIQALCSAQQLLQKTNDYRVF 111

Human   113 QTVFGERLFGQGLVSECNYERWHKQRRVIDLAFSRSSLVSLMETFNEKAEQLVEILEAKADGQTP 177
            :....|.||..|      :|:|..:|:::..||:.:.:...:..|.:::..|:..:...|:....
  Fly   112 ENWLCEGLFTSG------FEKWSHRRKIVMPAFNYTMIKQFVAVFEKQSRILLTNVAKFAESGDQ 170

Human   178 VSMQDMLTYTAMDILAKAAFGMETSMLLGAQKPLSQAVKLMLEGITAS------RNTLAKFLPGK 236
            :....:::...:|.:.:.|.|:.......|:.....|||.:|..|...      ||:   |:..:
  Fly   171 IDFLQLISCFTLDTICETALGVSVGSQSSAKSEYLDAVKSILVIIDKRLKNIFYRNS---FIFKR 232

Human   237 RKQLREVRESIRFLRQVGRDWVQRRREALKRGEEVPADILTQILKAE-EGAQDDEGLLDNFV--- 297
            ....:..:|.|:.|.......:|:|.:.:.:..|   :...|...|| :|.:.....||..:
  Fly   233 TSHYKREQELIKTLHGFTEGIIQKRIDEINQDAE---NRNYQSSDAELDGVKRTLCFLDTLLLSK 294

Human   298 -----------------TFFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVIGSKRY--LD 343
                             |....|.:.:|..|.|.:..::..||...|.:.||..|.|..:.  :.
  Fly   295 GPDGKPLTVKDIREEVDTIIFGGFDLTATTLNFFMYNMTLHPEHQQRCREEVWSVCGKDKSEPIS 359

Human   344 FEDLGRLQYLSQVLKESLRLYPPAWGTFRLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDP 408
            .|.:.:|::|...:||:||:||....|.|.......|:...:|..:.::.|...|||...:|.||
  Fly   360 IEQVRQLEFLEACIKETLRMYPSGPLTARKATANCTINDFFIPKGSDVIISPIYMGRCKDFFPDP 424

Human   409 LTFNPDRFGPGAPKPRF---TYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRLEFRLVPGQR--- 467
            :.|.|||:..|| :|:.   |:.||..|.|||:||::|.:.:|:|:|.||:...|..: |:|
  Fly   425 MVFKPDRWAIGA-EPKIEATTFIPFMAGARSCMGQRYAMVMLKMVLAHLLRNFLFEPL-GERQVK 487

Human   468 FGLQEQATLKPLDPVLC 484
            ..|....||..::|.||
  Fly   488 LKLNFVITLHTVEPYLC 504

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CYP46A1	NP_006659.1	p450	34..466	CDD:365848	109/480 (23%)
Cyp312a1	NP_001262008.1	p450	35..505	CDD:278495	117/503 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D825914at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920