Protein Alignment CYP46A1 and Cyp316a1

DIOPT Version :9

• Sequence 1: NP_006659.1
• Gene: CYP46A1 / 10858
• HGNCID: 2641
• Length: 500
• Species: Homo sapiens
• Sequence 2: NP_648129.2
• Gene: Cyp316a1 / 38840
• FlyBaseID: FBgn0035790
• Length: 484
• Species: Drosophila melanogaster
• Alignment Length: 519
• Identity: 120/519 - (23%)
• Similarity: 212/519 - (40%)
• Gaps: 89/519 - (17%)

Human    10 SAVLLAFGLCCTF----VHRARSRYEHIPGPPRPSFLLGHLPCFWKKDEVGGRVLQDVFL----- 65
            :|..:.|.|...|    ..|.||..:::.|           |..|   .:.|.:.:.:||
  Fly     4 TATFICFCLASAFNYFRARRQRSLIKNLKG-----------PFTW---PLMGAMHKLLFLTPINF 54

Human    66 -----DWAKKYGPVVRVNVFHKTSVIVTSPESVKKFLMSTKYNKDSKMYRALQTVFGERLFGQGL 125
                 ::..|||...|..|||:..:.:...|..::.|.:..:         |:|  |..|....|
  Fly    55 FQRSTEYLTKYGTFSRCWVFHRLFIPLADLELSRQLLENDTH---------LET--GYELMKDWL 108

Human   126 VS---ECNYERWHKQRRVIDLAFSRSSLVSLMETFNEKAEQLVEILEAKADGQTPVSMQDMLTYT 187
            |.   .|..|:|.|:..:|...|.:.:|..|::....:.|||::.|..:|| |....:...::..
  Fly   109 VGGVLMCQSEQWQKRHSLISGLFDKGNLEQLIDLSRHQTEQLLQKLAKQAD-QKVFDIWYTVSPI 172

Human   188 AMDILAKAAFGMETSMLLGAQ-KPLSQAV-KLMLEGITASR--------------NTLAKFLPGK 236
            .:|::.....|.:.|...... |.||:.. |..|...:|:|              |.|.|.|..:
  Fly   173 VLDLMVMTTCGAKPSEEYSKNLKDLSEIYRKRFLSLQSANRFNYWLSSPFMRKRQNRLIKRLNDE 237

Human   237 RKQLREVRESIRFLR-QVGRDWVQRRREALKRGEEVPADILTQILKAEEGAQDDEGLLDNFVTFF 300
            ...|..:.:|...|: :.|.|..|.|...||..:    .:|..:|::::.....|.:.....|..
  Fly   238 HNNLMAMHQSQNQLKIENGLDIYQLRPIPLKDHK----SLLEILLESKDPQLTGEEICGELNTCN 298

Human   301 IAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVIGSKRYLDFEDLGRLQYLSQVLKESLRLYP 365
            ..|::..:..|.|.::.::|.|.:   .|..:||:..::......||.:|.||..||.|::||||
  Fly   299 YLGYQLCSPALCFCLVTIARNPSV---QQKCLDELNLAQIKDQGWDLEKLNYLDAVLHETMRLYP 360

Human   366 PAWGTFRLLEEE-----TLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRFGPGAPKPRF 425
            |.....|.|:::     :::....:|..:.:..:.|.:.|.:..:.....|:..||....|:
  Fly   361 PQVIVGRQLKKDFPYTHSIVGDAELPCGSEIYINLYELQRNEVRYPKANHFDAQRFLDSPPE--- 422

Human   426 TYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQ-----------RLEFRLVPGQRFGLQEQATLKP 478
             ...:|||.|.|..::|:...:|.::|.:|.           ||:.|||.|...|.  |..|||
  Fly   423 -LLSYSLGPRCCPARKFSMQLLKTLLAPILANFEVLPYGDEVRLDLRLVLGSSNGF--QLALKP 483

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CYP46A1	NP_006659.1	p450	34..466	CDD:365848	107/477 (22%)
Cyp316a1	NP_648129.2	p450	33..466	CDD:299894	103/469 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910