Protein Alignment CYP46A1 and Cyp311a1

DIOPT Version :9

• Sequence 1: NP_006659.1
• Gene: CYP46A1 / 10858
• HGNCID: 2641
• Length: 500
• Species: Homo sapiens
• Sequence 2: NP_572780.3
• Gene: Cyp311a1 / 32170
• FlyBaseID: FBgn0030367
• Length: 483
• Species: Drosophila melanogaster
• Alignment Length: 501
• Identity: 129/501 - (25%)
• Similarity: 214/501 - (42%)
• Gaps: 79/501 - (15%)

Human     5 LLLLGSAVLLAFGLCCTFVHRARSRYEHIPGP---PRPSFLLGHLPCFWKKDEVGGRVLQD---- 62
            ||.|||:                     :|||   |    |||:.       ::.|::..:
  Fly    22 LLRLGSS---------------------LPGPWAFP----LLGNA-------QMVGKLRPEYIFL 54

Human    63 VFLDWAKKYGPVVRVNVFHKTSVIVTSPESVKKFLMSTKYNKDSKMYRALQTVFGERLFGQGLVS 127
            ||.:...::|...|:.:..:..|.:.|.|..::.|      .|..:.:|...:..|.|.|.||:.
  Fly    55 VFTELRDRFGATYRLRLGPQLWVFLHSAEETRQAL------HDPTLRKADTFMQLEPLIGNGLLI 113

Human   128 ECNYERWHKQRRVIDLAFSRSSLVSLMETFNEKAEQLVEILEAKADGQTPVSMQDMLTYTAMDIL 192
            . :...|.:|||::..||....|.|.........|:||..|.|.......|:  :.|....:|.:
  Fly   114 S-HGAHWTRQRRLLTPAFQPQLLRSFAPAIGGHVERLVGRLGATRGAFLEVT--EPLFACLLDAI 175

Human   193 AKAAFGMETSMLLGAQKPLSQA--------VKLMLEGITASRNTLAKFLPGKRKQL-REVRESIR 248
            ...:.|.:.........|:.||        .|.|:..:.:|....      :|.|| |::.|.::
  Fly   176 VDTSMGAQLDTQSVDHSPIIQAFHLSSKLLFKRMINPLLSSDWIF------QRTQLWRDLDEQLQ 234

Human   249 FLRQVGRDWVQRR-REALKRGEEVPA----DILTQILKAE-EG-AQDDEGLLDNFVTFFIAGHET 306
            .:.......:::| :|.|..||  ||    ::|..:|.|: || :.....:.|...||..||.:|
  Fly   235 VIHSQMESVIEKRAKELLDMGE--PAGRAHNLLDTLLLAKFEGQSLSRREIRDEINTFVFAGVDT 297

Human   307 SANHLAFTVMELSRQPEIVARLQAEVDEVIGSKRYLDFEDLGRLQYLSQVLKESLRLYPPAWGTF 371
            :...::|.:..|::.||...||:.|:.:| ......|.:.|..|.||..::||.||||.....|.
  Fly   298 TTAAMSFVLYALAKFPETQTRLRKELQDV-ALDETTDLDALNGLPYLEALIKEVLRLYTIVPTTG 361

Human   372 RLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRF----GPGAPKPRFTYFPFSL 432
            |...:.|.|.|........|..:.|.:.....|:.||..|.|:|:    |..|| |.|:|.|||.
  Fly   362 RQTTQSTEIGGRTYCAGVTLWINMYGLAHDKEYYPDPYAFKPERWLPEDGAVAP-PAFSYIPFSG 425

Human   433 GHRSCIGQQFAQMEVKVVMAKLLQRLEFRLVPGQR-FGLQEQATLK 477
            |...|||::::.:.:|::.|:|::..:..|.|.|. ..|:.|..||
  Fly   426 GPHVCIGRRYSLLLMKLLTARLVREFQMELSPEQAPLRLEAQMVLK 471

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CYP46A1	NP_006659.1	p450	34..466	CDD:365848	119/458 (26%)
Cyp311a1	NP_572780.3	p450	30..480	CDD:278495	124/472 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910