Protein Alignment CYP46A1 and Cyp4d2

DIOPT Version :9

• Sequence 1: NP_006659.1
• Gene: CYP46A1 / 10858
• HGNCID: 2641
• Length: 500
• Species: Homo sapiens
• Sequence 2: NP_001284806.1
• Gene: Cyp4d2 / 31192
• FlyBaseID: FBgn0011576
• Length: 501
• Species: Drosophila melanogaster
• Alignment Length: 520
• Identity: 158/520 - (30%)
• Similarity: 256/520 - (49%)
• Gaps: 60/520 - (11%)

Human     7 LLGSAVLLAFG--LCCTFVHRARSRYEHIPGPPRPSFLLGHLPCFWKKDEVGGRVLQDVFLDWAK 69
            ::|..:|:||.  |...|:.|.|.. ..:|| |||...||:|..:...|       .:..:|:.|
  Fly     4 VVGVLLLVAFATLLLWDFLWRRRGN-GILPG-PRPLPFLGNLLMYRGLD-------PEQIMDFVK 59

Human    70 ----KYGPVVRVNVFHKTSVIVTSPESVKKFLMSTKYNKDSKMYRALQTVFGERLFGQGLVSECN 130
                |||.:.||.:.|:.:|..|.|..::..|.|.::...:.:|:.|....|:     ||:....
  Fly    60 KNQRKYGRLYRVWILHQLAVFSTDPRDIEFVLSSQQHITKNNLYKLLNCWLGD-----GLLMSTG 119

Human   131 YERWHKQRRVIDLAFSRSSLVSLMETFNEKAEQLVEILEAKADGQTPVSMQDMLTYTAMDILAKA 195
             .:||.:|::|...|....|...:|.|::::..:||.|:::|||.||:::..::..||:||:|:.
  Fly   120 -RKWHGRRKIITPTFHFKILEQFVEIFDQQSAVMVEQLQSRADGMTPINIFPVICLTALDIIAET 183

Human   196 AFGMETSMLLGAQK----PLSQAVK-----LMLEGITASRNTLAKFLPGKRKQLREVRESIRFLR 251
            |.|.:    :.|||    |..|||.     |:...|.|.:.....|...:..:.:...::|:.:.
  Fly   184 AMGTK----INAQKNPNLPYVQAVNDVTNILIKRFIHAWQRVDWIFRLTQPTEAKRQDKAIKVMH 244

Human   252 QVGRDWVQRRREALKRG-------EEVP----------ADILTQILKAEEGAQ-DDEGLLDNFVT 298
            ....:.::.|||.|...       |||.          .|:|.|  ...:||. .||.:.:...|
  Fly   245 DFTENIIRERRETLVNNSKETTPEEEVNFLGQKRRMALLDVLLQ--STIDGAPLSDEDIREEVDT 307

Human   299 FFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVIGSKRY--LDFEDLGRLQYLSQVLKESL 361
            |...||:|:.:.::|.:.|:||.||:..|||.|:.:|:|..|.  :...|||.|:::..|:||||
  Fly   308 FMFEGHDTTTSAISFCLYEISRHPEVQQRLQQEIRDVLGEDRKSPVTLRDLGELKFMENVIKESL 372

Human   362 RLYPPAWGTFRLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRFGPGAPKPR-F 425
            ||:||.....|...|:..|.|..:|..|......:|:.|...|||.|..|.|:||....|:.. :
  Fly   373 RLHPPVPMIGRWFAEDVEIRGKHIPAGTNFTMGIFVLLRDPEYFESPDEFRPERFDADVPQIHPY 437

Human   426 TYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRLE-FRLVPGQRFGLQEQATLKPLDPVLCTLRPR 489
            .|.|||.|.|:||||:||.:|:|..::|||:..| ..|.|..|..:  ...|:..:.|...|:||
  Fly   438 AYIPFSAGPRNCIGQKFAMLEMKSTVSKLLRHFELLPLGPEPRHSM--NIVLRSANGVHLGLKPR 500

Human   490  489
              Fly   501  500

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CYP46A1	NP_006659.1	p450	34..466	CDD:365848	144/466 (31%)
Cyp4d2	NP_001284806.1	p450	32..495	CDD:278495	147/484 (30%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810