Protein Alignment CYP46A1 and Cyp4g1

DIOPT Version :9

• Sequence 1: NP_006659.1
• Gene: CYP46A1 / 10858
• HGNCID: 2641
• Length: 500
• Species: Homo sapiens
• Sequence 2: NP_525031.1
• Gene: Cyp4g1 / 30986
• FlyBaseID: FBgn0010019
• Length: 556
• Species: Drosophila melanogaster
• Alignment Length: 516
• Identity: 121/516 - (23%)
• Similarity: 226/516 - (43%)
• Gaps: 85/516 - (16%)

Human     2 SPGL-LLLGSAVLLAFGLCCTFVHRARSRYEH-----IPGPPRPSFLLGHLPCFWKKDEVGGRVL 60
            ||.| .|:|:.|.:|.     :.:..|:..|:     ||.||       .||...:.....|...
  Fly    25 SPMLTTLVGTLVAMAL-----YEYWRRNSREYRMVANIPSPP-------ELPILGQAHVAAGLSN 77

Human    61 QDVF---LDWAKKYGPVVRVNVFHKTSVIVTSPESVKKFLMSTKYNKDSKMYRALQTVFGERLFG 122
            .::.   |.:..|||..::..:.:...|.:|:|..::..|...::...::.||..:..||:.|
  Fly    78 AEILAVGLGYLNKYGETMKAWLGNVLLVFLTNPSDIELILSGHQHLTKAEEYRYFKPWFGDGL-- 140

Human   123 QGLVSECNYERWHKQRRVIDLAFSRSSLVSLMETFNEKAEQLVEILEAKADGQTPVSMQDMLTYT 187
              |:|  |...|...|::|...|.:|.|.|.:.||.:.::.:|..:..:| |:: ..:.|.::.|
  Fly   141 --LIS--NGHHWRHHRKMIAPTFHQSILKSFVPTFVDHSKAVVARMGLEA-GKS-FDVHDYMSQT 199

Human   188 AMDILAKAAFGMETSMLLGAQKPLSQAVKLMLEGITASR-------NTLAKFLPGKRKQLREVRE 245
            .:|||...|.|::...........:|||..|.:.|...:       :::.||...:.|..|.:..
  Fly   200 TVDILLSTAMGVKKLPEGNKSFEYAQAVVDMCDIIHKRQVKLLYRLDSIYKFTKLREKGDRMMNI 264

Human   246 SIRFLRQVGRDWVQRRREALKRG-----EEVPADILTQILKAEEGAQDD---------------- 289
            .:....:|.:|    |:|..:..     ||:...:.:.....:||.:||
  Fly   265 ILGMTSKVVKD----RKENFQEESRAIVEEISTPVASTPASKKEGLRDDLDDIDENDVGAKRRLA 325

Human   290 ------------------EGLLDNFVTFFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVI 336
                              :.::|...|....||:|::...:|.:..:....:|.|::.||...:.
  Fly   326 LLDAMVEMAKNPDIEWNEKDIMDEVNTIMFEGHDTTSAGSSFALCMMGIHKDIQAKVFAEQKAIF 390

Human   337 GSKRYLD--FEDLGRLQYLSQVLKESLRLYPPAWGTFRLLEEE-TLIDG-VRVPGNTPLLFSTYV 397
            |.....|  |.|...::||.:|:.|:||||||.....|.|:.: .|..| ..||..|.::...|.
  Fly   391 GDNMLRDCTFADTMEMKYLERVILETLRLYPPVPLIARRLDYDLKLASGPYTVPKGTTVIVLQYC 455

Human   398 MGRMDTYFEDPLTFNPDRFGPG--APKPRFTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQ 456
            :.|....:.:|..|:||.|.|.  |.:..:::.|||.|.|||:|:::|.:::||:::.:::
  Fly   456 VHRRPDIYPNPTKFDPDNFLPERMANRHYYSFIPFSAGPRSCVGRKYAMLKLKVLLSTIVR 516

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CYP46A1	NP_006659.1	p450	34..466	CDD:365848	111/478 (23%)
Cyp4g1	NP_525031.1	p450	58..518	CDD:278495	111/478 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910