|
Human 5 PSP----AHPQLPVLQTQMVSDGMTGSNPVSP------------------ASSSSPASSGAGG-I 46
|:| .:|.:|: :.|..|:.| |||.|.|:||.|| :
Fly 410 PAPPAAVGNPSVPL---------VPGGTPLLPCNTSAGSTALRRPQGQNNASSGSAAASGGGGSL 465
Human 47 SPQHIAQ---DSSLDGPPGPPDGATVPLEGFSLSQAADLANKGPKWEKSHAEIAEQAKHEAEIET 108
:|..:.. .::|.|..|...| .|..|..||.|....:..| ..:..|.:.:||.|..:..
Fly 466 TPTPLYTGNGPAALGGSGGLTPG--TPTSGSLLSPALGGGSGTP--NSAAQEFSFKAKQEVYVMQ 526
Human 109 RIAELRKEGFWSLKRLPKVPEPPRPKGHWDYLCEEMQWLSADFAQERRWKRGVARKVVRMVIRHH 173
||:||::||.|:.:||||:.||.|||.|||||.|||.||:|||||||:||:..|:|..:||.::.
Fly 527 RISELQREGLWTERRLPKLQEPSRPKAHWDYLLEEMVWLAADFAQERKWKKNAAKKCAKMVQKYF 591
Human 174 EEQRQKEERARREEQAKLRRIASTMAKDVRQFWSNVEKVVQFKQQSRLEEKRKKALDLHLDFIVG 238
:::....:||.:.::.:|:|:||.:|::|:.|||||||:|::|.|:::|||||:|||.||.|||.
Fly 592 QDKATAAQRAEKAQELQLKRVASFIAREVKSFWSNVEKLVEYKHQTKIEEKRKQALDQHLSFIVD 656
Human 239 QTEKYSDLLSQSLNQPLTSSKAGSSPCLGSSSAASSPPPPASRLDDEDGDFQPQEDEEEDDEETI 303
||||:|..|.:.:|: ....:|.|.||...| |....|| ||:| |...|||||||
Fly 657 QTEKFSQQLVEGMNK-----SVADTPSLNSSRLTS----PKRESDD---DFRP-ESGSEDDEETI 708
Human 304 EVEEQQEGNDAEAQRREIELLRREGELPLEELLRSLPPQLLEGPSSPSQTPSSHDSDTRDGPEEG 368
...|: ||...:.|:..|.:|.|:..::.|..|||..|| .|| :.
Fly 709 AKAEE----DAADVKEEVTALAKESEMDFDDFLNDLPPGYLE---------------NRD---KL 751
Human 369 AEEEPPQVLEIKPPPSAVTQRNKQPWHPDEDDEEFTANEEEAEDEEDTIAAEEQLEGEVDHAMEL 433
.:||....::.:.| .|.||.||.| :|.::|:|:||:.:|:.|.|:||..|:
Fly 752 MKEEQSSAIKTETP-------------DDSDDSEFEA-KEASDDDENTISKQEEAEQEIDHKKEI 802
Human 434 SELAREGELSMEELLQQYAGAYAPGSGSSEDEDEDEVDANSSDCEPEGPVEAEEPPQEDSSSQSD 498
.||..:.:||:|:||.:|.....| .|:....|...|:.||...|.
Fly 803 DELEADNDLSVEQLLAKYKSEQPP--------------------SPKRRKLAPRDPELDSDDDST 847
Human 499 SVEDRSEDEEDEHSEEEETSGSSASEESESEESEDAQSQSQADEEEEDDDFGVEYLLARDEEQSE 563
:| |.:|:.||..:|:||.. |:...:::.|| .:|:|| |::.|:| :
Fly 848 AV-DSTEESEDAATEDEEDL-STVKTDTDMEE----------QDEQED---GLKSLMA------D 891
Human 564 ADAGSGPPTPGPT--TLGPKKE-ITDIAAAAESLQPKGYTLATTQVKTPIPLLLRGQLREYQHIG 625
|||.||....|.| ..|.|.: :.|.||.||||||||.||::|.|.||:|.||:..||||||||
Fly 892 ADATSGAAGSGSTAGASGNKDDMLNDAAALAESLQPKGNTLSSTNVVTPVPFLLKHSLREYQHIG 956
Human 626 LDWLVTMYEKKLNGILADEMGLGKTIQTISLLAHLACEKGNWGPHLIIVPTSVMLNWEMELKRWC 690
|||||||.|:|||||||||||||||||||:|||||||.|||||||||:||:|||||||||.|:||
Fly 957 LDWLVTMNERKLNGILADEMGLGKTIQTIALLAHLACAKGNWGPHLIVVPSSVMLNWEMEFKKWC 1021
Human 691 PSFKILTYYGAQKERKLKRQGWTKPNAFHVCITSYKLVLQDHQAFRRKNWRYLILDEAQNIKNFK 755
|.||||||||:||||||||.||||||||||||||||||:||.|:||||.|:||||||||||||||
Fly 1022 PGFKILTYYGSQKERKLKRVGWTKPNAFHVCITSYKLVVQDQQSFRRKKWKYLILDEAQNIKNFK 1086
Human 756 SQRWQSLLNFNSQRRLLLTGTPLQNSLMELWSLMHFLMPHVFQSHREFKEWFSNPLTGMIEGSQE 820
|||||.||||:::||||||||||||.|||||||||||||:||.||||||||||||:||||||:.|
Fly 1087 SQRWQLLLNFSTERRLLLTGTPLQNDLMELWSLMHFLMPYVFSSHREFKEWFSNPMTGMIEGNME 1151
Human 821 YNEGLVKRLHKVLRPFLLRRVKVDVEKQMPKKYEHVIRCRLSKRQRCLYDDFMAQTTTKETLATG 885
|||.|:.|||||:|||||||:|.:|||||||||||||.||||.|||.||:|||::..|:|||.||
Fly 1152 YNETLITRLHKVIRPFLLRRLKKEVEKQMPKKYEHVITCRLSNRQRYLYEDFMSRAKTRETLQTG 1216
Human 886 HFMSVINILMQLRKVCNHPNLFDPRPVTSPFITPGICFSTASLVLRATDVHPLQRIDMGRFD--L 948
:.:||||:||||||||||||:|:.||..|||...||.|.|..||....:..|..:|::...: |
Fly 1217 NLLSVINVLMQLRKVCNHPNMFEARPTISPFQMDGITFHTPRLVCDIMEYDPFTQINLETLNLLL 1281
Human 949 IGLEGRVSRYEADTFLPRHRL---SRRVLLEVATAPDPPPRPKPVKMKVNRMLQPVPKQEGRTVV 1010
:.||..::.|.:. :.|| .|:::.::.|||.|.||....|.:.:
Fly 1282 LHLEQTMTAYVSH----KSRLLAPPRKLIEDIDTAPLPAPRCPNGKYRFH--------------- 1327
Human 1011 VVNNPRAPLGPVPVRPPPGPELSAQPTPGPVPQVLPASLMVSASPAGPPLIPASRPPGPVLLPPL 1075
:.|| ||: |...:.::|...|.. ||.|..|..::|
Fly 1328 -----------IRVR-------SAE---------LAQRIKLNAVKVGAS--PAMRLEGSKIMP-- 1361
Human 1076 QPNSGSLPQVLPSPLGVLSGTSRPPTPTLSLKPTPPAPVRLSPAPPPGSSSLLKPLTVPPGYTFP 1140
:..:|||. .||...| .|:.|...| |||:.:
Fly 1362 ------MRNLLPSG-RVLKRVS------ASINPVNMA---------------LKPVVI------- 1391
Human 1141 PAAATTTSTTTATATTTAVPAPTPAPQRLILSPDMQARLPSGEVVSIGQLASLAQRPVANAGGSK 1205
.|..|.|:::|...:|| |.|:.|: .||
Fly 1392 ------NSVVTTTSSSTTASSPT------------------------GALSVLS--------NSK 1418
Human 1206 PLTFQIQGNKLTLTGAQVRQLAVGQPRPLQRNVVHLVSAGGQHHLISQPAHVALIQAVAPTPGPT 1270
|.||: .|..||||.
Fly 1419 ------------LLGAR-------------------------------------SQINAPTPA-- 1432
Human 1271 PVSVLPSSTPSTTPAPTGLSLPLAANQVPPTMVNNTGVVKIVVRQAPRDGLTPVPPLAPAPRPPS 1335
:|..|| :||
Fly 1433 --------------------------KVAKTM---------------QDG--------------- 1441
Human 1336 SGLPAVLNPRPTLTPGRLPTPTLGTARAPMPTPTLVRPLLKLVHSPSPEVSASAPGAAPLTISSP 1400
:|...| :|..::.|.||. ||::|
Fly 1442 ------------------------------------KPFFYL----TPATNSGAAGAR-LTLTS- 1464
Human 1401 LHVPSSLPGPASSPMPIPNSSPLASPVSSTVSVPLSSSLPISVPTTLPAPASAPLTIPISAPLTV 1465
..|.
Fly 1465 -------------------------------------------------------------KTTA 1468
Human 1466 SASGPALLTSVTPPLAPVVPAAPGPPSLAPSGASPSASALTLGLATAPSLSSSQTPGHPLLLAP- 1529
|||.....|:|| :|.|.|..|:..|
Fly 1469 SASTTTSRTTVT---------------------------------------ASTTSGQQLIRDPI 1494
Human 1530 ---TSSHVPGLNSTVAPACSPVLVPASALASPFPSAPNPAPAQASLLAPASSASQALATPLAPMA 1591
.::|| .|||
Fly 1495 VKDLATHV---KSTV-------------------------------------------------- 1506
Human 1592 APQTAILAPSPAPPLAPLPVLAPSPGAAPVLASSQTPVPVMAPSSTPGTSLASASPVPAPTPVLA 1656
Fly 1507 ----------------------------------------------------------------- 1506
Human 1657 PSSTQTMLPAPVPSPLPSPASTQTLALAPALAPTLGGSSPSQTLSLGTGNPQGPFPTQTLSLTPA 1721
Fly 1507 ----------------------------------------------------------------- 1506
Human 1722 SSLVPTPAQTLSLAPGPPLGPTQTLSLAPAPPLAPASPVGPAPAHTLTLAPASSSASLLAPASVQ 1786
|..|:|.|
Fly 1507 --------QKQSIANG------------------------------------------------- 1514
Human 1787 TLTLSPAPVPTLGPAAAQTLALAPASTQSPASQASSLVVSASGAAPLPVTMVSRLPVSKDEPDTL 1851
|.||:..
Fly 1515 ----------------------------------------------------------KTEPEEE 1521
Human 1852 TLRSGPPSPPSTATSFGGPRPRRQPPPPPRSPFYLDSLEEKRKRQRSERLERIFQLSEAHGALAP 1916
| ....|:.:..|.:.||.||...|:|:..::.......|
Fly 1522 T--------------------------EAEDPYKVQELIQMRKEQRLAALKRMAMINRRRTDATP 1560
Human 1917 VYG---TEVLDFC-----TLPQPVASPIGPRS--PGPSHPTFWTYTEAAHRAVLFPQQRLDQLSE 1971
:|| .|.:..| :|.:......|..: ...:|...|:.. |....| ::|...|..
Fly 1561 IYGEDCREAIQRCMQATRSLKRSTWQTRGYANCCTAMAHRNGWSLN---HLLKSF-EERCADLKP 1621
Human 1972 IIERFIFVMPPVEAPPPSLHACHPPPWLAPRQAAFQEQLASELW---------------PRARPL 2021
:...|:..:|.| | |||...:.:.|:|..| |:...|
Fly 1622 VFANFVIYVPSV---------C------APRIRRYVQNLSSTHWQHEQRIENIVDQALRPKLALL 1671
Human 2022 HRIVCNMRTQFPDLRLIQYDCGKLQTLAVLLRQLKAEGHRVLIFTQMTRMLDVLEQFLTYHGHLY 2086
|.|:..|.|:|||.||||||||||||:..||||||..|||||||||||:||||||.||.||||:|
Fly 1672 HPIISEMTTKFPDPRLIQYDCGKLQTMDRLLRQLKVNGHRVLIFTQMTKMLDVLEAFLNYHGHIY 1736
Human 2087 LRLDGSTRVEQRQALMERFNADKRIFCFILSTRSGGVGVNLTGADTVVFYDSDWNPTMDAQAQDR 2151
|||||||||||||.||||||.|||||||||||||||||:||||||||:|||||||||||||||||
Fly 1737 LRLDGSTRVEQRQILMERFNGDKRIFCFILSTRSGGVGINLTGADTVIFYDSDWNPTMDAQAQDR 1801
Human 2152 CHRIGQTRDVHIYRLISERTVEENILKKANQKRMLGDMAIEGGNFTTAYFKQQTIRELFDMPLEE 2216
|||||||||||||||:||||:|.||||||||||||.|||||||||||.|||..||::||.|...|
Fly 1802 CHRIGQTRDVHIYRLVSERTIEVNILKKANQKRMLSDMAIEGGNFTTTYFKSSTIKDLFTMEQSE 1866
Human 2217 PSSSSVPSAPEEEEETVAS--------------KQT-HILEQALCRAEDEEDIRAATQAKAEQVA 2266
...||...: |.::..||: ||: ...|.||..||||:|::|...||||..|
Fly 1867 QDESSQEKS-ENKDRIVATTTLSDTPSTVVETEKQSLRAFEHALAAAEDEQDVQATKTAKAEVAA 1930
Human 2267 ELAEFNENDGFPAGEGEEAGRPGAEDEEMSRAEQEIAALVEQLTPIERYAMKFLEASLEEVSREE 2331
:||||:|| .|... |:....|....|:|:|:.|:..||:||:|||||||:|:|.:....:.|:
Fly 1931 DLAEFDEN--IPIAT-EDPNAEGGPQVELSKADLEMQNLVKQLSPIERYAMRFVEETGAAWTAEQ 1992
Human 2332 LKQAEEQVEAARKDLD-------QAKEEVFRLPQEEEE--------------------------- 2362
|:.||.::||.:::.: ..:||:.:...|.||
Fly 1993 LRAAEAELEAQKREWEANRLAAMHKEEELLKQETEAEEMLTYSRKDSSNQVWISRNTMEQMPMWC 2057
Human 2363 ---GPGAGD---------------------------------ESSCGTGGGTHRRSKKAKAP--- 2388
.|...| .|....|....||..|.:..
Fly 2058 PPTPPQDNDNDIYIDYSLSFMYELEPIAETDLPPVYVRKEHKRSRTDAGYDGSRRPNKMRREDNY 2122
Human 2389 -------ERPGTRV--------SERLRG------------------------ARAE--------- 2405
:||..:: |:|.|| |.||
Fly 2123 VPPRSLFDRPTPQLARLRRELKSQRFRGSFKPNMPIPGLKPQLPTKPLTEPEAMAEWCVFEDMAI 2187
Human 2406 ------TQG---------ANHTP---------------VISAHQTR---STTTPPR------CSP 2431
.|| ...|| ..||.|.| .|...|| .||
Fly 2188 LHVLVNLQGLPCSLMLLSPGQTPNWDLVSEMVNFCSKTYRSARQCRWRYETHIQPREEGKVVESP 2252
Human 2432 ARERVPRP----------------------------------------------APRPRPTPASA 2450
.:::..:| ||.|: ...||
Fly 2253 KKQKKLKPTLRTEYLKSPLRYLRTTQLYVSDNNASFYKTMRSRFDSIKTAYLKKAPPPK-RQFSA 2316
Human 2451 PAAI-PALVPV-----------PVSAPVPISAPN----------------PITILPVHIL----- 2482
|:.: |..:.| ||| |..|:|.. |:.:..|..:
Fly 2317 PSLMNPKHMEVLQEFGILNYDQPVS-PQNIAAMKANKIREKQRGQQMSQPPVGVGVVQQMQQQSQ 2380
Human 2483 ----PSPPP------------------------------PSQIPPCSSPACTPPPACTPPPAHTP 2513
|:||| ..|:|..|:...|.|...|.......
Fly 2381 QQQQPAPPPLPQQQQPQQVVQQVQQQQQQQQQQQQQQVVQQQLPTVSNVQQTLPVQQTVELVQQQ 2445
Human 2514 PPAQTCLVTPS------------------SP-----LLLGPPS---------------------- 2533
|...|.:..|: || :||..|.
Fly 2446 PTTTTTVAVPAAGGQLQQLQIQHLTSSNVSPGQQTAILLHQPQQQLRTHPGQGGQSNTQQLVKTI 2510
Human 2534 VPISASVTNLPLGLRPEAELCAQALASPESLELASVASSETSSLSLV--PPKDLLPVAV------ 2590
|..|:|:|...| |.|| :.::|||...||:|:| .|...||..|
Fly 2511 VGTSSSLTAGQL----------QQLA-----QQSAVASGGQSSVSVVLTTPVQTLPSVVQPQIGS 2560
Human 2591 --EILPVSEKNLSLTPSAPSL--TLEAGSIP-------------------NGQEQEAPDSAEGTT 2632
:|:.:|.:.|.:. |:|.| .::..|:| |..:|:...:|..|.
Fly 2561 GAQIVSISSQTLPVN-SSPQLGSIVQTQSLPQVVSVSTLPTVGTVLTTTANQPQQQHQTTAVTTL 2624
Human 2633 LTVLPEGEELPLCVSESNGLELPPSAASDEPLQEP-----LEADRTSEELTEAKTPTSSPEKPQE 2692
.|.:..|:.: :..:..|.|:...:|.....:..| ....:...:|..|..|||...:..:
Fly 2625 NTTMLRGQRI-VSTAAGNTLQQRTTAGGQSIVSMPNLGQGASPSQFQTQLRLAAVPTSPATQTTQ 2688
Human 2693 LVTAE---VAAPSTSSSATSSP----EGPSPARPPRRRTSADVEIRGQGTGRPGQPPGPKVLRKL 2750
|||.: |:|.......|..| .|.:..:..|:|:...::...|.. |.|.......
Fly 2689 LVTTKGIPVSALQQGGKTTVIPVTQQSGGAHIQLYRQRSLKVLQTTTQAV-----PSGSAGATGA 2748
Human 2751 PGRLV----TVVEEKELVRRRRQQRGAASTLVPGVSETSASPGSPSVRSMSGPESSPPI----GG 2807
...|| |:::...:......|:.|.|.: ||.|.|..:....|...|.|...:..| .|
Fly 2749 TANLVQAGGTIIQASNMATHVTSQKVAVSGM-PGTSTTVQAGNVVSSVQMHGQARTQFIKQMAAG 2812
Human 2808 PCE------AAPSSSLPTPPQQPFIARRHIELGVTGGGSPENGDGALLAIT---PPAVKRRRGRP 2863
..: :|..::..|......:.:|| .:......:...|||...| ....::::|:.
Fly 2813 KQQLQRQVVSADGTTTTTAAGDMLLVKRH---NILAAQKAQQASGALFTTTTGQQQQQQQQQGQL 2874
Human 2864 PKKNRSPADAGRGVDEAPSSTLKGKTNGADPVPGPETLIVADPVLE--------PQLIPGPQPLG 2920
|...:........:.....::.....:|:....|..|:...:|.:: |||.||.|
Fly 2875 PVAGQPQQVTQHQIASLVKASTAAAASGSSVNAGGVTVSATNPTVQAGSVNMTLPQLKPGSQ--- 2936
Human 2921 PQPVHRPNPLLSPVEKRRRGRPPKARDLPIPGTISSAGDGNSESRTQPPPHPSPLTPLPPLLVCP 2985
..|..||.: |.|.: :.:...|...|.:|.|......|
Fly 2937 -IKVTMPNQM---------------RHLQM------------QQQLTMPRKISRMTQLVSASGQP 2973
Human 2986 TATVANTVTTVTISTSPPKRKRGRPPKNPPSPRPSQLPVLDRDSTSVLESCGLGRRRQPQGQGES 3050
||| |.:|| |.|.::::|..... ...||.: ..:::|.|.|.:.
Fly 2974 TAT--NIITT----TGPQQQQQGVTVSG-----GGTLPTV------------ASQQQQQQHQQKV 3015
Human 3051 EGSSSDE------DGSRPLTRLARLRLEAEGMRGRKSGGSMVVAVIQDDLDLADSGPGGLELTPP 3109
.|.:|.: ..::.|:....::...:.||..:.| .:...:|.|..:..| .:.|.
Fly 3016 GGGNSVQAQLLHIQNTKGLSNSVTMQQIQQVMRSGQQG-----TLATTNLVLGKTSVG--RVIPV 3073
Human 3110 VVSLTPKLRSTRLRPGSLVPPLETEKLPRKRAGAPVGGSPGLAKRGRLQPPSPLGPEGSVEESEA 3174
.|:.....|.|. .:|.....:.|........|.| |.:|...::..|...|.: :.:::..
Fly 3074 SVASQANQRQTI----QVVSAASAQALAAGNLRTHVAG-PSIASTLKVAAPGSAGGQ-TTQQTLI 3132
Human 3175 EASGEEEEGDGTPRR--RPGPRRLVGTTNQGDQRILRSSAPPSLAGPA 3220
.|....:..:.:|.| ......|:....|..|:...|.|.|: ||||
Fly 3133 AALQHNQRQNASPVRLQTTAGGNLLAVVQQQQQQQHTSIAGPT-AGPA 3179
| 
