|
Human 127 VPEP-PRPKGHWDYLCEEMQWLSADFAQERRWKRGVARKVVRMVIRHHEEQRQKEERARREEQAK 190
||.| |||:. :.|.:.....:.|...|....:|::.:|..: ..:|:...|...:||...:
Fly 6 VPAPQPRPRA----MAEPLHIQRLEAALNMRPFMNMAKRSLRKPL-SSDEETDDEHVVKREHDVQ 65
Human 191 LRRIASTMAKDVRQFWSNVEKVVQFKQQSRLEEKRKKALDLHLDFIVGQTEKYSDLLSQSLN-QP 254
....:||:. ||:.||.| |||..| :...|:...:.:|..| ..
Fly 66 DSDDSSTVG------------VVRMKQSS----KRKSRL-------LASKEERQSVKAQLYNFND 107
Human 255 LTSSKAGSSPCLGSSSAASSPPPPASRLDDEDGDFQPQEDEEEDDEETI--EVEEQQEGND---- 313
|||.:......| |.|.:.| .|...|:|..::.: .|.||::..:
Fly 108 LTSDREWLYDLL---------------LSDTESD-DPTITEDEYVQQLLREHVREQRQRKNYYKK 156
Human 314 -AEAQ----------------RREIEL--LRREGELPLEELLRSLPPQLLEGPSSPSQTPSSHDS 359
|.|| .|::.. :|:......:|:|.:...:...||..|.|.......
Fly 157 AANAQYAYYGSGLLSNHDIFAERQLATAGVRKRRRRTKQEILMARLAEAQAGPKPPKQRRRGRKK 221
Human 360 -DTRDGPEEGAEEEPPQVLEIKPPPSAVTQRNKQPWHPDEDDEEFTANEEEAEDEEDTIA----A 419
|....||.| :.|||.:.:.......|:.:|::....|.:.:.|..::| .
Fly 222 RDNMGSPESG-----------EVPPSELGKYTFGDTLPNNEDDDEDGGEVDYKRELASLALDYPE 275
Human 420 EEQLEGEVDHAMELSELAREGELSMEELLQQYAGAYAPG-------SGSSEDEDEDEVDANS--- 474
||::|.||| .|...||:::.....::...|.|.. ....|......:.:|:
Fly 276 EEEIEEEVD-----VEGGTEGQVTKVRRKRKNPAALAARRRRIWQIMSKKESGRLQRIKSNNHKE 335
Human 475 --SDCEPEGPVEAEEPPQEDSSSQS-----------------------DSVEDRSEDEEDEHSEE 514
::|:....:.|:...|...:||. :.||.....:::..:||
Fly 336 MLANCKRVAGMCAKVVRQRAINSQRIMKETVWRAKRLTREMLAYWKRYERVERDQRRKQEREAEE 400
Human 515 EETSGSSASEESESEE-----------------------SEDAQSQ--SQADEE-------EEDD 547
:........|....:. ||:.|.: ||.||| ::|.
Fly 401 QRKQDVELIEVKRQQRKLNFLITQTELYAHFMSKKLGQGSEEDQLRILSQLDEETNARLAAQDDY 465
Human 548 DFGVEYLLARDEE----QSEADAGSGPPTPGPTTLGPKKEITDIAAAAESL-----QPKGYTLAT 603
|.|...|||::.. |.:.| .|........|||..:...|.||: :|:
Fly 466 DAGEMKLLAQENAEAAMQRDLD-----KTRAFDVFAKKKEKEEEEQAQESVEDIKPEPR------ 519
Human 604 TQVK-TPIPLLLRGQLREYQHIGLDWLVTMYEKKLNGILADEMGLGKTIQTISLLAHLACEKGNW 667
.::| .|.|.:.:|.|:.||..|:.||..:|::.::||||||||||||:|:|:.|.|:|...|.|
Fly 520 PEMKDLPQPKMFKGTLKGYQIKGMTWLANIYDQGISGILADEMGLGKTVQSIAFLCHIAEHYGVW 584
Human 668 GPHLIIVPTSVMLNWEMELKRWCPSFKILTYYGAQKERKLKRQGW------TKPNAFHVCITSYK 726
||.|:|.|.|.:.||:.|:.|:.|.||::.|:|:..|||:.||.| |:..:|||.||||:
Fly 585 GPFLVISPASTLHNWQQEMSRFVPDFKVVPYWGSPAERKILRQFWDQKHLHTRDASFHVVITSYQ 649
Human 727 LVLQDHQAFRRKNWRYLILDEAQNIKNFKSQRWQSLLNFNSQRRLLLTGTPLQNSLMELWSLMHF 791
||:.|::.|.|..|:|::|||||.||:..||||:.||.|:.:.||||:|||:|||:.|||:|:||
Fly 650 LVVSDYKYFNRIKWQYMVLDEAQAIKSAASQRWKLLLGFSCRNRLLLSGTPIQNSMAELWALLHF 714
Human 792 LMPHVFQSHREFKEWFSNPLTGMIEGSQEYNEGLVKRLHKVLRPFLLRRVKVDVEKQMPKKYEHV 856
:||.:|.||.||.||||..:....|.....:|..:.|||.:|:||:|||:|.|||.::..|.|.:
Fly 715 IMPTLFDSHDEFNEWFSKDIESHAENKTGIDEKQISRLHMILKPFMLRRIKKDVENELSDKIEIM 779
Human 857 IRCRLSKRQRCLY---------DDFM----AQTTTKETLATGHFMSVINILMQLRKVCNHPNLFD 908
:.|.|:.||:.|| :|.: ..|||..:.:..:.| |::||.|||||||.||:
Fly 780 VYCPLTIRQKLLYRALKQKIRIEDLLHLTSGSTTTSSSSSASNLM---NLVMQFRKVCNHPELFE 841
Human 909 PRPVTSPFITPGICFSTASLVLRATDVHPLQRIDMGRFDLIGLEGRVSRYEADTFLPRHRLSRRV 973
.|...|||. :|..: :.:.| ||..||.:.| .|| ||:.
Fly 842 RRDARSPFF------------MRCAE-YTIPR-------LIHEEGLIHR-----MLP----SRKH 877
Human 974 LLEVATAPDPPPRPKPVKMKVNRMLQPVPKQEGRTVVVVNNPRAPLGPVPVRPPPGPELSAQPTP 1038
|| .||.
Fly 878 LL------------------YNRF----------------------------------------- 883
Human 1039 GPVPQVLPASLMVSASPAGPPLIPASRPPGPVLLPPLQPNSGSLPQVLPSPLGVLSGTSRPPTPT 1103
.:..:..:
Fly 884 ----NIFKSEYI----------------------------------------------------- 891
Human 1104 LSLKPTPPAPVRLSPAPPPGSSSLLKPLTVPPGYTFPPAAATTTSTTTATATTTAVPAPTPAPQR 1168
..||.:.:.|...:.|
Fly 892 --------------------QRSLFEDVNVNSCFGF----------------------------- 907
Human 1169 LILSPDMQARLPSGEVVSIGQLASLAQRPVANAGGSKPLTFQIQGNKLTLTGAQVRQLAVGQPRP 1233
.||.. :|:|.:. ::||.|
Fly 908 --------TRLCD---LSVGDMV-----------------------EVTLNG------------- 925
Human 1234 LQRNVVHLVSAGGQHHLISQPAHVALIQAVAPTPGPTPVSVLPSSTPSTTPAPTGLSLPLAANQV 1298
||....|..
Fly 926 ----------------LIDFLLHYR---------------------------------------- 934
Human 1299 PPTMVNNTGVVKIVVRQAPRDGLTPVPPLAPAPRPPSSGLPAVLNPRPTLTPGRLPTPTLGTARA 1363
.||...|.|...| ....:.
Fly 935 -----------------------------------------RVLEKYPLLAYRR-----FWWKKQ 953
Human 1364 PMPTPTLVRPLL--KLVHSPSPEVSASAPGAAPLTISSPLHVPSSLPGPASSPMPIPNSSPLASP 1426
|.....|:.|:| || |...|| ||
Fly 954 PDSRYQLLEPMLENKL---------------------------------ALDYMP-PN------- 977
Human 1427 VSSTVSVPLSSSLPISVPTTLPAPASAPLTIPISAPLTVSASGPALLTSVTPPLAPVVPAAPGPP 1491
Fly 978 ----------------------------------------------------------------- 977
Human 1492 SLAPSGASPSASALTLGLATAPSLSSSQTPGHPLLLAPTSSHVPGLNSTVAPACSPVLVPASALA 1556
|.|...:.||
Fly 978 -----------SVLKNFIFTA-------------------------------------------- 987
Human 1557 SPFPSAPNPAPAQASLLAPASSASQALATPLAPMAAPQTAILAPSPAPPLAPLPVLAPSPGAAPV 1621
|.|.::::.|
Fly 988 ---------------------------------MTANESSVYA---------------------- 997
Human 1622 LASSQTPVPVMAPSSTPGTSLASASPVPAPTPVLAPSSTQTMLPAPVPSPLPSPASTQTLALAPA 1686
Fly 998 ----------------------------------------------------------------- 997
Human 1687 LAPTLGGSSPSQTLSLGTGNPQGPFPTQTLSLTPASSLVPTPAQTLSLAPGPPLGPTQTLSLAPA 1751
.|.:.|..:..|....::
Fly 998 ---------------------FGDYFTYNMQETIEHRVI-------------------------- 1015
Human 1752 PPLAPASPVGPAPAHTLTLAPASSSASLLAPASVQTLTLSPAPVPTLGPAAAQTLALAPASTQSP 1816
.:..|...:|....:...|.|.|.:....|.|
Fly 1016 --------------RSKILKKKTSLIEEMEDVSKQKLEIESVEVQT------------------- 1047
Human 1817 ASQASSLVVSASGAAPLPVTMVSRLPVSKDEPDTLTLRSGPPSPPSTATSFGGPRPRRQPPPPPR 1881
.::..:.:.||.:..||.....| .:||:....|..
Fly 1048 ---------KSNAKSDVKVTTLLLLPEFPHRP---------------------RKPRKYVCEPLS 1082
Human 1882 SPFYLDSLEEKRKRQRSERLERIFQLSEAHGALAPVYGTEVLDFCTLPQPVASPIGPRSPGPSHP 1946
.|..|..|.:| :...|..| :|.
Fly 1083 MPRILYDLGQK--------------VQAVHRYL----------YCD------------------- 1104
Human 1947 TFWTYTEAAHRAVLFPQQRLDQLSEIIERFIFVMPPVEAPPPSLHACHP-PPWLAPRQAAFQEQL 2010
.|:..:.|.|.:|......| |.....|..|.| ..|.:
Fly 1105 ---------SRSAAWSQIRHNQCENSQGR--------ELVSSGLALCKPHGGWSS---------- 1142
Human 2011 ASELWPRARPLHRIVCNMRTQFPDLRLIQYDCGKLQTLAVLLRQLKAEGHRVLIFTQMTRMLDVL 2075
|| .||...:..|.|||..|..||.:|||.||||||::|||:|:|:|
Fly 1143 -------------IV------VPDKETLITDAGKLFVLDNLLTRLKANGHRVLIYSQMTKMIDLL 1188
Human 2076 EQFLTYHGHLYLRLDGSTRVEQRQALMERFNADKRIFCFILSTRSGGVGVNLTGADTVVFYDSDW 2140
|:::.:..|.|:|||||:::..|:.::..|.....||.|:||||:||:|:|||.||||:||||||
Fly 1189 EEYMWHRKHRYMRLDGSSKISARRDMVADFQTRADIFVFLLSTRAGGLGINLTAADTVIFYDSDW 1253
Human 2141 NPTMDAQAQDRCHRIGQTRDVHIYRLISERTVEENILKKANQKRMLGDMAIEGGNFTTAYFKQQT 2205
|||:|.||.||.||:|||:.|.:||||.:.|:||.||::|.:|..:..|.|.||| ||..|
Fly 1254 NPTVDQQAMDRAHRLGQTKQVTVYRLICKGTIEERILQRAREKSEIQRMVISGGN-----FKPDT 1313
Human 2206 I--RELFDMPLEE-------------PSSSSVPSAPEEE------EETVASKQTHILEQALCRAE 2249
: :|:..:.|:: .|||.:|:|.:.| ::.|....|.|...:..:..
Fly 1314 LKPKEVVSLLLDDEEIEMKYRQEAKLQSSSPIPAATQSERKRRHPQKDVNMGGTTIAATSATQNP 1378
Human 2250 DEEDIRAATQAKAEQVAELAEFNE-----------NDGFPAGEGEEAGRPGAEDEEMSRAEQEIA 2303
|::....::.||..::....:|.: .|.......:|...|||...:.:..:.|..
Fly 1379 DDDVPSCSSAAKRIKLETEEDFIDVGITSSASSVGTDSNHPTLSQETYVPGATCVQQTEIDSENE 1443
Human 2304 ALV---EQLTPI-ERYAMKFLEASLEEVSREELKQAEEQVEAARKDLDQAKEEVFRLPQEEEEGP 2364
||| :..|.: :..:|.||: .|..:|....:.. |:....|.
Fly 1444 ALVVDGDSPTMLGQNESMNFLD-DLSGISPMRRRHH---------------------PRGTRRGR 1486
Human 2365 GAGDESSCGTGGGTHR--RSKKAKAPERPGTRVSERLRGARA-----------ETQGANHTPVIS 2416
..|.....|..|...| ...:|..|..|.|.......|..| |..|......:.
Fly 1487 PRGSTRRGGGHGSIPRVLTPTQAATPAVPATASQAAAAGTGAAAGTSSPLPQQEVSGGGDNAGVP 1551
Human 2417 AHQTRSTTTPPRCSPARERVPRPAPRPR---PTPAS-----APAAI----PALVPV--------P 2461
.|:....|:|...||. ....|...||| .||.| ||.|. |.|||: |
Fly 1552 LHEEEYRTSPSGQSPG-VSCKRGPGRPRSKTATPISRGTRGAPRARRPMGPLLVPLGRSPDDTPP 1615
Human 2462 VSAPVPISAPNPIT 2475
.|:|....||:|::
Fly 1616 SSSPATSRAPSPLS 1629
| 
