Protein Alignment TUBGCP2 and SPC97

DIOPT Version :10

• Sequence 1: NP_001243546.1
• Gene: TUBGCP2 / 10844
• HGNCID: 18599
• Length: 930
• Species: Homo sapiens
• Sequence 2: NP_012042.1
• Gene: SPC97 / 856577
• SGDID: S000001215
• Length: 823
• Species: Saccharomyces cerevisiae
• Alignment Length: 829
• Identity: 179/829 - (21%)
• Similarity: 311/829 - (37%)
• Gaps: 219/829 - (26%)

Human   241 QESAVVEDLLYVLVGVDGRYV----SAQPLAGRQSRTFLVDPNLDLSIRELVHRILPVAASYSAV 301
            ||:.||:|||.||:|::|.|:    ..:|........|.:...:|.|.:....||:.....|..:
Yeast    55 QEALVVKDLLNVLIGLEGTYIRYFNDYEPSDPETPIEFKIAKKMDPSFKTFSRRIVRYGKQYMIL 119

Human   302 TRFIEEKSSFEYGQVNHALAAAMRTLVKEHLI--LVSQLEQ-LHRQGLLSLQKLWFYIQ--PAMR 361
            ||..|:.|...:|.|....|..:|..:::..:  ||.:||: .::....|:::|...|.  ...:
Yeast   120 TRAYEKWSDTSFGMVLQRFAYEIRRFLEDVYLKTLVERLERDFNKVPNFSIRELEQIINETEVNK 184

Human   362 TMDILASLATSV-----------------------DKGEC------------------LGGSTLS 385
            .|::|.::...:                       .|.|.                  .||:.|.
Yeast   185 QMELLYNIYEEIFREIEERRTNQSSQEDFNNFMDSMKNESSLHLRLMVAFDTTVYPVPKGGAILK 249

Human   386 LLHDRSFSYTGDSQAQELCLYLTKAASAPYFEVLEKWIYRGIIHDPYSEFMV-EEHELRKERIQE 449
            :...:.....||..:......|....|..|..:|.:|:.:||::|||.|||. ::.|.:.:.| .
Yeast   250 IFQQKILENLGDRSSVMFLKKLLNNISQDYCTMLYEWLTQGILNDPYQEFMTYDDLEGKTDNI-F 313

Human   450 DYNDKYWDQRYTIVQQQIPSFLQKMAD-----KILSTGKYLNVVRECGHDVTCP------VAKEI 503
            |..|:.||.:|.|.:..:........|     |:|.||..|.|||......|.|      ..:||
Yeast   314 DTRDRAWDTQYFIRKDVLLRDCDSEEDKNLLFKMLRTGILLKVVRASLQIPTIPSNSSDITIQEI 378

Human   504 --IYTLKERAYVE-QIEKAFNYASKVLLDFLMEEKELVAHLRSIKRYFL-MDQGDFFVHFMDLAE 564
              ...|.|.:.:| .::|.::.|:::.|....:..:|:..|:.:::.|| ...|...:.|:....
Yeast   379 NDFADLMEGSNLELYVDKCYSRANEIFLKLFFQGYDLINVLKHLQQIFLGYQSGHNVLKFLTKNM 443

Human   565 EELRKPVEDITPPRLEALLE-LALRMSTANTDPFKDDLKIDLMPHDLITQLLRVLAIETKQEKAM 628
            .||.|...:......:.||: ..|...:.|             |::|:.|||.:........:.:
Yeast   444 GELTKHYRNDNNANYDKLLQNFELERQSEN-------------PNNLMRQLLMIQFDTETLPQVL 495

Human   629 AH-----------------ADP---------------TELAL--------SGLEAFS-------- 645
            :|                 :||               .||:.        |.||.::
Yeast   496 SHYLQIYPEVPENNSANDDSDPLMHANNFKNMNAILFDELSKERTGAYHGSNLELYTPKSAIYHL 560

Human   646 -FDYIVKWPLSLIINRKALTRYQMLFRHMFYCKHVERQLCSVWIS-NK-----------TAKQHS 697
             ||..:.:||::||:|..:.:||::.|:....::..|.|...|:. ||           |.|:..
Yeast   561 KFDINIPYPLNIIISRTCMIKYQIILRYQLVLQYHSRLLDETWMDLNKTPSWKYRGYSHTVKRRI 625

Human   698 LHSAQWFAGAFTLRQRMLNFVQNIQYYMMFEVMEPTWHILEK---NLKSASNIDDVL-GHHTGFL 758
            :.:.:      .|..:|.:|::.|..|....|::...:.|||   |...|..|.:.| |..|..:
Yeast   626 VRATR------VLHAKMNHFIKTIMEYFNQNVIDKEVYSLEKCYRNPTLAVAIQNELEGGLTNIM 684

Human   759 -DTCLKDCMLTNPELLKVFSKLMSVCVMFTNCMQKFTQSMK-----LDGEL-------------- 803
             :.||.|.:   |..|::|..:...|        ||.:||:     ||..|
Yeast   685 TNRCLSDLI---PLQLQIFDIVYKFC--------KFIKSMRAKLCQLDPVLYEKHKSGMMKTLNE 738

Human   804 ------GGQTLEHSTVLGLPAGAEERARKELARKHLAEHADTVQLVSGFEATINKFDKNFSAHLL 862
                  |||.         ..|.:|.|..||.:|       .::.:|...:...|...||:..|
Yeast   739 GYRTNNGGQE---------DVGYQEDAALELIQK-------LIEYISNASSIFRKCLINFTQEL- 786

Human   863 DLLARLSIYSTSDCEHGMASVISRLDFNGFYTERLERLSAERSQKATPQ 911
             ...:...|.:|..:   |:.|.|:         |..:...||..|:.|
Yeast   787 -STEKFDFYDSSSVD---AAGIERV---------LYSIVPPRSASASSQ 822

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TUBGCP2	NP_001243546.1	GCP_N_terminal	246..534	CDD:465456	80/352 (23%)
		GCP_C_terminal	537..893	CDD:461187	91/448 (20%)
SPC97	NP_012042.1	GCP_N_terminal	60..410	CDD:465456	80/350 (23%)
		GCP_C_terminal	<560..>653	CDD:461187	23/98 (23%)