Protein Alignment TUBGCP2 and t-Grip91

DIOPT Version :10

• Sequence 1: NP_001243546.1
• Gene: TUBGCP2 / 10844
• HGNCID: 18599
• Length: 930
• Species: Homo sapiens
• Sequence 2: NP_723933.1
• Gene: t-Grip91 / 34931
• FlyBaseID: FBgn0028901
• Length: 1931
• Species: Drosophila melanogaster
• Alignment Length: 831
• Identity: 163/831 - (19%)
• Similarity: 299/831 - (35%)
• Gaps: 236/831 - (28%)

Human   123 PAAASKISMQELEEL--RKQLGSVATGSTLQQSLELKRKMLRDKQNKKNSGQHLPIFPAWVYERP 185
            |...:.:.:.:||:|  ||:          :.:.|..|...|||.::..|.:.|        ...
  Fly  1266 PDLITIVGVAQLEQLLTRKE----------RAAYESMRWQSRDKGDQDLSAESL--------FTD 1312

Human   186 ALIGDFLIGAGISTDTALPIVLLRWNLALSPRLKCSGVISAHCNLHLPGTLPLAS---QESAVVE 247
            ||.|  ::|.|                  ||.||.|.         |.|.|.|.|   ||| :.|
  Fly  1313 ALHG--MMGYG------------------SPHLKLSS---------LTGRLQLRSPHHQES-ISE 1347

Human   248 DLLYVLVGVDGRYVSAQPLAGRQSRTFLVDPNLDLSIRELVHRILPVAASYSAVTRFIEEKSSFE 312
            ..|.:.:|..|.:                       .|||...:..:|                |
  Fly  1348 SYLLLALGHFGYF-----------------------YRELKEHLARLA----------------E 1373

Human   313 YGQVNHALAAAMRTLVKEHLILVSQLEQLHRQGLLSLQKLWFYIQPAMRTMDILASLATSVDKGE 377
            .|..    |.|:|..::::|:.:.|...:.::...||..|:...:...|..:.|..:..:|.|.:
  Fly  1374 QGDT----ALALRKCLQKYLLNLHQFYDVQKRNPSSLLSLYRRTRDFQRNFEWLLEVFNNVQKAK 1434

Human   378 CLGGSTLSLLHDRSFSYTGDSQAQELCLYLTKAASAPYFEVLEKWIYRGII----HDPYSEFMVE 438
                |.:..|:..|...||  ..:.|.|...:....|....|..|:..|.:    ||   .|::|
  Fly  1435 ----SIVVYLYKESSRRTG--YQRNLLLKWLRLVIQPLIYNLHIWLLNGRLPSTDHD---MFVIE 1490

Human   439 EHELRKERIQEDYNDKYWDQRYTIVQQQIPSFLQKMADKILSTG-------KYLNVVRECGHDVT 496
            :.:..|.       |::|::||.|.:.....|..::::.::|.|       |||.:..|     :
  Fly  1491 QTKYSKV-------DEFWEKRYRITESFSGIFDPQLSEILISVGKTMEYSEKYLAINFE-----S 1543

Human   497 CPVAKEIIYTLKER-----AYVEQIEKAFNYASKVLLDFLMEEKELVAHLRSIK----------- 545
            |...||:...|.|.     .:.:| |..:|:...:.|:.   ..:::.:||..|
  Fly  1544 CVPRKEVRCMLLETFDKFLRHGDQ-EPLYNFVRNLHLEI---SSKVLKYLRKTKINPEYLFSGLH 1604

Human   546 RYFLMDQGDFFVHFMDLAEEELRKPVEDITPPRLEALLELALRMSTANTDPFKDDLKIDLMPHDL 610
            :|.::...:|.:.|::..|..|.:|                  .|:.|...|.:      |.:.:
  Fly  1605 KYIMLTDLNFIMEFINALESVLGEP------------------ESSFNIQLFNE------MKNKM 1645

Human   611 ITQLLRVLAIETKQEKA--------MAHADPTE-LALSGLEAFSFDYIVK--WPLSLI--INRKA 662
            :.:.:|.:.|:..:.:.        :....||. .||.|.::.:::.|.|  |....:  :..:.
  Fly  1646 LHKSVRDIYIDKSESEGSRCWSKLILRWKMPTHWRALLGEDSKAYEVIFKAMWRFHYVYYVLNER 1710

Human   663 LTRYQMLFRHMFYCKHVERQLCSVWISNKTAKQHSLHSAQWFAGAFTLRQRMLNFVQNIQYYMMF 727
            :.|.|:.|::...|.:.|.       .|.|.|..|           .|....|..:..:..|.:.
  Fly  1711 VHRQQIRFQNHIECTYFEG-------LNDTLKCFS-----------KLTNACLRLMNVLMEYFLD 1757

Human   728 EVMEPTWHILEKNLKSASNIDDVLGHHTGFLDTCLKDCMLTNPELLKVFSKLMSVCVMFTNCMQK 792
            .::||.:..|....::|..:|::|..:..:|.|.:...:.|. .|.|...:|..:.:...|...|
  Fly  1758 YLLEPAFARLLWYCRNAITVDELLVANRKYLKTIILGSLQTK-NLRKYLERLYDLILQLDNKHWK 1821

Human   793 FTQSMKLDGELGGQTLEHSTVLGLPAGAEERARKE--------LARKHLAEHADTVQLVSGFEAT 849
            |.:..:...|.         |:        |.|||        ..|:.:.:...|.|   .:...
  Fly  1822 FLRLCQTSVEY---------VI--------RVRKEKPQSIFSTYYRERMLQFRWTCQ---NYSDV 1866

Human   850 INKFDKNFSAHLLDLLARLSIYSTSDCEHGMASVISRLDFNGFYTERLERL 900
            ||:....|...::..|  |.::...|  ..:.|:..|||...:|.|:..||
  Fly  1867 INEMKDQFDLAMISFL--LCLHLADD--DSLRSLAKRLDPEHYYMEKDNRL 1913

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TUBGCP2	NP_001243546.1	GCP_N_terminal	246..534	CDD:465456	59/303 (19%)
		GCP_C_terminal	537..893	CDD:461187	69/387 (18%)
t-Grip91	NP_723933.1	GCP_N_terminal	1312..1591	CDD:465456	78/376 (21%)
		GCP_C_terminal	<1690..1906	CDD:461187	49/258 (19%)