DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ALDH1L1 and CG31075

DIOPT Version :9

Sequence 1:	NP_001257293.1	Gene:	ALDH1L1 / 10840	HGNCID:	3978	Length:	912	Species:	Homo sapiens
Sequence 2:	NP_001247324.1	Gene:	CG31075 / 43244	FlyBaseID:	FBgn0051075	Length:	508	Species:	Drosophila melanogaster

Alignment Length:	503	Identity:	227/503 - (45%)
Similarity:	317/503 - (63%)	Gaps:	19/503 - (3%)

- Green bases have known domain annotations that are detailed below.

Human   420 EMAVNKRTVRMPH----------QLFIGGEFVDAEGAKTSETINPTDGSVICQVSLAQVTDVDKA 474
            ::||:::..:..|          ||||..||||:...||..|.||.....|.|||.....|:|.|
  Fly    12 QLAVSRKWSKFDHTYAQCEPNYCQLFINNEFVDSVSGKTFATFNPATSKEIVQVSEGDKADIDLA 76

Human   475 VAAAKDAF-ENGRWGKISARDRGRLMYRLADLMEQHQEELATIEALDAGAVYTLALKTHVGMSIQ 538
            |.|||.|| .:..|.|:|...|..||.:|..||::.:..||::|..|.|..|..|| ..|..||.
  Fly    77 VKAAKKAFHRDSEWRKLSPLQRTNLMNKLCALMDRDKAFLASLETQDNGKPYAEAL-FDVTYSIL 140

Human   539 TFRYFAGWCDKIQGSTIPINQARPNRNLTLTRKEPVGVCGIIIPWNYPLMMLSWKTAACLAAGNT 603
            |.:|:|||.||..|.|||....     :::||||||||.|.||||||||:||:||....||.|.|
  Fly   141 TLQYYAGWTDKFFGDTIPAGGF-----VSMTRKEPVGVVGQIIPWNYPLLMLAWKWGPALAVGCT 200

Human   604 VVIKPAQVTPLTALKFAELTLKAGIPKGVVNVLPGSGSLVGQRLSDHPDVRKIGFTGSTEVGKHI 668
            :::|||:.||||||..|.|..:||.|.||:||:.|.|...|..:|.|||:.|:.||||.|:|:.:
  Fly   201 IIMKPAEQTPLTALHMAALAKEAGFPAGVINVVNGFGPTAGAAISAHPDIAKVAFTGSVEIGRIV 265

Human   669 MKSCAISNVKKVSLELGGKSPLIIFADCDLNKAVQMGMSSVFFNKGENCIAAGRLFVEDSIHDEF 733
            |::.|.||:|:||||||||||:::|.|.|::.||:....::|.|.|::|.|..|.:|.:.|:|||
  Fly   266 MQAAATSNLKRVSLELGGKSPVVVFDDADIDFAVETTHEALFSNHGQSCCAGSRTYVHEKIYDEF 330

Human   734 VRRVVEEVRKMKVGNPLDRDTDHGPQNHHAHLVKLMEYCQHGVKEGATLVCGGNQVPRPGFFFEP 798
            |.:...:.:..|||||.:::...|||.....|.|::.|.:.|.||||.|..||.::...|||.||
  Fly   331 VAKAAAKAKARKVGNPFEQNVQQGPQIDDDMLTKVLGYIESGKKEGAKLQAGGKRIGNVGFFVEP 395

Human   799 TVFTDVEDHMFIAKEESFGPVMIISRFADGDLDAVLSRANATEFGLASGVFTRDINKALYVSDKL 863
            |||:||:|.|.||:||.||||..|.:|:  .|:.::.|||..::|||:||.|.||||||..::.:
  Fly   396 TVFSDVKDDMRIAQEEIFGPVQSIFKFS--SLEEMIDRANNVQYGLAAGVITNDINKALKFANNV 458

Human   864 QAGTVFVNTYNKTDVAAPFGGFKQSGFGKDLGEAALNEYLRVKTVTFE 911
            .||:|::|.|:....:.||||:|.||.|::||:..|:.||..||:|.:
  Fly   459 DAGSVWINCYDAVLPSTPFGGYKHSGIGRELGKDGLDNYLETKTITMK 506

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ALDH1L1	NP_001257293.1	Fmt	10..319	CDD:223301
		FMT_core_FDH_N	11..213	CDD:187716
		FDH_Hydrolase_C	216..316	CDD:187731
		PP-binding	335..401	CDD:278949
		ALDH_F1L_FTFDH	427..912	CDD:143458	225/496 (45%)
CG31075	NP_001247324.1	ALDH-SF	33..506	CDD:299846	224/480 (47%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150017
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1012
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D153834at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.750