Protein Alignment ALDH1L1 and CG6661

DIOPT Version :10

• Sequence 1: NP_001257293.1
• Gene: ALDH1L1 / 10840
• HGNCID: 3978
• Length: 912
• Species: Homo sapiens
• Sequence 2: NP_648686.3
• Gene: CG6661 / 39556
• FlyBaseID: FBgn0036403
• Length: 581
• Species: Drosophila melanogaster
• Alignment Length: 520
• Identity: 111/520 - (21%)
• Similarity: 206/520 - (39%)
• Gaps: 76/520 - (14%)

Human   416 IDYVEMAVNKRTVRMPHQLFIGGEFVDAEGAKTSETINPTDGSVIC-----QVSLAQV-----TD 470
            :::....:..|.:.:|  ..||           .:|:...|...:|     |.:||.|     ..
  Fly    71 VNHAIQEIQHRPLEVP--TIIG-----------DDTVYTMDTQRVCCPHHLQTNLAHVYYANRKQ 122

Human   471 VDKAVAAAKDAFENGRWGKISARDRGRLMYRLADLMEQHQEELATI------EALDAGAVYTLAL 529
            ::.|:.:|..|  .|.|..:....|..:..|.|.::|:.:..|...      :..|........|
  Fly   123 IEAAIKSALSA--QGTWSLVPIAQRLAIWRRAATIIEEDELRLRVFLMMTLSKTADDATRDIRRL 185

Human   530 KTHVGMSIQTFRYFAGWCDKIQG--STIPINQARPNRNLTLTRKEPVGVCGIIIPWNYPLMMLSW 592
            .|.:..:.....:.:....:|||  :..|....||..          |....:.|  :..:.||.
  Fly   186 LTSLRANADYLEHLSELRFEIQGDMNVFPSFHLRPMD----------GFVAALAP--FESVALSS 238

Human   593 KTAACLA-AGNTVVIKPA-QVTPLTALKFAELTLKAGIPKGVVNVLPGSGSLVGQRLSDHPDVRK 655
            ..|.|.| .||||:..|: :|.|::.|.|.... :||:|.||:|.:|.:..|....::|......
  Fly   239 SLALCPALMGNTVLWNPSLEVAPVSYLIFRAFQ-EAGLPSGVINFVPANERLFLDTITDAVHFAG 302

Human   656 IGFTGSTEVGKHIMKSCAISN-------VKKVSLELGGKSPLIIFADCDLNKAVQMGMSSVFFNK 713
            :....|....:|:.|  .:|:       ..::..|..|::...:.|...:...|...:.:.|...
  Fly   303 LNTQASAAFYRHVHK--LVSDRMERYICFPRLVAECPGQNFHFVHASAKVESVVSATVQAAFGFA 365

Human   714 GENCIAAGRLFVEDSIHDEFVRRVVEEVRKMKVGNPLDRDTDHGPQNHHAHLVKLMEYCQHGVKE 778
            |:...:..|::|..|:.......:||...::.:|:|::.:||.|...|.....::.:..|.  .:
  Fly   366 GQYANSLSRMYVPSSMWPRLREELVEATEQLTIGDPIESETDIGAMVHINDFRRMQKLLQR--TK 428

Human   779 GATLVCGGNQVPRPGFFFEPTV--FTDVEDHMFIAKEESFGPVMIISRFADGDL-DAVLSRANAT 840
            ....:|||:.....|.|.:||:  .:|..|.:..  |...||.:.:..::|... :|:...||.:
  Fly   429 NMEQLCGGSCDDSTGRFVDPTIVRVSDPLDPLLC--EPCCGPFLPVFVYSDDSFSEALKLAANQS 491

Human   841 EFGLASGVFTRDINKALYVSDKLQ--AGTVFVN------TYNKTDVAAPFGGFKQSGFGKDLGEA 897
            .:.|:..:|.......|:..::|:  |..::||      ||..|    ||||.:.||.....|.|
  Fly   492 RYALSGSIFASQDEVILHCLNQLRMSASNLYVNERCTGSTYGLT----PFGGNRLSGTNDKSGSA 552

Human   898  897
              Fly   553  552

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ALDH1L1	NP_001257293.1	FMT_core_FDH_N	11..213	CDD:187716
		FDH_Hydrolase_C	216..316	CDD:187731
		ALDH_F1L_FTFDH	427..912	CDD:143458	110/509 (22%)
CG6661	NP_648686.3	ALDH-SF	68..567	CDD:448367	111/520 (21%)