Protein Alignment ALDH1L1 and CG8665

DIOPT Version :10

• Sequence 1: NP_001257293.1
• Gene: ALDH1L1 / 10840
• HGNCID: 3978
• Length: 912
• Species: Homo sapiens
• Sequence 2: NP_610107.1
• Gene: CG8665 / 35407
• FlyBaseID: FBgn0032945
• Length: 913
• Species: Drosophila melanogaster
• Alignment Length: 914
• Identity: 548/914 - (59%)
• Similarity: 682/914 - (74%)
• Gaps: 17/914 - (1%)

Human    11 MKIAVIGQSLFGQEVY-CHLRKEGHEVVGVFTVPDKDGKADPLGLEAEKDGVPVFKYSRWRAKGQ 74
            |:||:||||.|..:|. ..|.:...::|||||:|||..:.|.|...|....:||||::.||.||.
  Fly     5 MRIAIIGQSNFAADVLELLLDRSNIQIVGVFTIPDKGSREDILATTATIHNIPVFKFACWRRKGV 69

Human    75 ALPDVVAKYQALGAELNVLPFCSQFIPMEIISAPRHGSIIYHPSLLPRHRGASAINWTLIHGDKK 139
            |||:|:.:|:::||.||||||||||||||:|:....|||.||||:||||||||||:||||.||:.
  Fly    70 ALPEVLEQYKSVGATLNVLPFCSQFIPMEVINGALLGSICYHPSILPRHRGASAISWTLIEGDEV 134

Human   140 GGFSIFWADDGLDTGDLLLQKECEVLPDDTVSTLYNRFLFPEGIKGMVQAVRLIAEGKAPRLPQP 204
            .||||||||||||||.|||.::..|...||:.|:|.|||:|||:|.|..||.::|.|.||::.||
  Fly   135 AGFSIFWADDGLDTGPLLLTRQTNVESTDTLDTIYKRFLYPEGVKAMGVAVDMVASGTAPKIIQP 199

Human   205 EEGATYE-GIQKKETAKINWDQPAEAIHNWIRGNDKVPGAWT-----EACEQKLTFFNSTLNTSG 263
            |.||||: .:.|.|...||....||.|.|::||.|.||||..     ...|:::..|.:.|.::|
  Fly   200 EVGATYDPAMFKTENQVINLQATAEKIWNFVRGLDSVPGAIATVLHGNGTEEQIRLFGAHLYSAG 264

Human   264 LVPEGDALPIPGAHRPGVVTKAGLILFGNDDKMLLVKNIQLEDGKMILASNFFKGAA-SSVLELT 327
            .|..|..|.:.|..:...:...||::.|.|...:.::.|: ...|:|.||.:||.|. .|:.:.:
  Fly   265 PVSNGKVLRLRGLTKTAWIHSGGLLIEGTDGAFVNIRRIK-RGTKVISASEWFKQAEDQSITDFS 328

Human   328 EAELVTAEAVRSVWQRILPKVLEVEDSTDFFKSGAASVDVVRLVEEVKELCDGLELENEDVYMAS 392
            |.|||....:..:|:.||.:  :||.|||||.|||.|:|||||||||||..| :.|:||.|:||.
  Fly   329 EDELVKRSLLAGIWKAILKE--DVESSTDFFASGAGSMDVVRLVEEVKEAFD-VPLQNEQVFMAP 390

Human   393 TFGDFIQLLVRKLR-GDDEEGECSIDY--VEMAVNKRTVRMPHQLFIGGEFVDAEGAKTSETINP 454
            .|.:|..||||.|| |....|...:|:  ..:..|||.:|:|.||||.|||||||..:|.|.:||
  Fly   391 VFEEFFSLLVRFLRQGSAGFGNQQLDFEAFTLKANKREIRVPTQLFINGEFVDAEAQRTLEIVNP 455

Human   455 TDGSVICQVSLAQVTDVDKAVAAAKDAFENGRWGKISARDRGRLMYRLADLMEQHQEELATIEAL 519
            |:..|:|:|:.|..|||||||.||..|| .|.|.:|:.|.||:||..||||||:::|||||||::
  Fly   456 TNEEVLCKVACASATDVDKAVRAAHSAF-YGSWRQITPRQRGQLMLNLADLMERNKEELATIESV 519

Human   520 DAGAVYTLALKTHVGMSIQTFRYFAGWCDKIQGSTIPINQARPNRNLTLTRKEPVGVCGIIIPWN 584
            |:||||||||||||||||:.:||||||||||||:|||:|.||||..||.|||||:||||:|.|||
  Fly   520 DSGAVYTLALKTHVGMSIEAWRYFAGWCDKIQGNTIPVNPARPNNVLTFTRKEPIGVCGLITPWN 584

Human   585 YPLMMLSWKTAACLAAGNTVVIKPAQVTPLTALKFAELTLKAGIPKGVVNVLPGSGSLVGQRLSD 649
            |||||||||.|||:|||||.:|||||..|||||||||||::||.|.||:|||||.||..||.::|
  Fly   585 YPLMMLSWKMAACIAAGNTCLIKPAQTCPLTALKFAELTVRAGFPPGVINVLPGKGSDAGQAVAD 649

Human   650 HPDVRKIGFTGSTEVGKHIMKSCAISNVKKVSLELGGKSPLIIFADCDLNKAVQMGMSSVFFNKG 714
            |..|||:||||||.:|||||||||.||:||.|||||||||||||||||::|||:.||||||||||
  Fly   650 HELVRKLGFTGSTPIGKHIMKSCADSNLKKCSLELGGKSPLIIFADCDMDKAVKHGMSSVFFNKG 714

Human   715 ENCIAAGRLFVEDSIHDEFVRRVVEEVRKMKVGNPLDRDTDHGPQNHHAHLVKLMEYCQHGVKEG 779
            |||||||||||||.|||||:|||::::|.|.:|:||||.|.||||||.||..||:|:|:.||.||
  Fly   715 ENCIAAGRLFVEDRIHDEFIRRVLKDLRTMTIGDPLDRSTAHGPQNHKAHFDKLLEFCRRGVDEG 779

Human   780 ATLVCGGNQVPR-PGFFFEPTVFTDVEDHMFIAKEESFGPVMIISRFADGDLDAVLSRANATEFG 843
            |.||.||.:||. .|:||.|||||:|.|.||||:||||||:||||:|...|:|:::.|||.||:|
  Fly   780 AKLVYGGCRVPNLKGYFFTPTVFTNVTDDMFIAQEESFGPIMIISKFNGSDIDSLMQRANRTEYG 844

Human   844 LASGVFTRDINKALYVSDKLQAGTVFVNTYNKTDVAAPFGGFKQSGFGKDLGEAALNEYLRVKTV 908
            |||||||:||.|||..:|:::|||||||.|||||||||||||||||:|||||:.||||||:.|.|
  Fly   845 LASGVFTKDIGKALNFADRIEAGTVFVNVYNKTDVAAPFGGFKQSGYGKDLGQEALNEYLKTKCV 909

Human   909 TFEY 912
            |.||
  Fly   910 TVEY 913

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ALDH1L1	NP_001257293.1	FMT_core_FDH_N	11..213	CDD:187716	117/203 (58%)
		FDH_Hydrolase_C	216..316	CDD:187731	31/104 (30%)
		ALDH_F1L_FTFDH	427..912	CDD:143458	343/485 (71%)
CG8665	NP_610107.1	FMT_core	5..207	CDD:444886	117/201 (58%)
		FDH_Hydrolase_C	212..316	CDD:187731	31/104 (30%)
		PP-binding	336..394	CDD:425746	33/60 (55%)
		ALDH_F1L_FTFDH	428..913	CDD:143458	343/485 (71%)