DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Galnt2 and Pgant9

DIOPT Version :9

Sequence 1:	NP_644678.2	Gene:	Galnt2 / 108148	MGIID:	894694	Length:	570	Species:	Mus musculus
Sequence 2:	NP_001097342.1	Gene:	Pgant9 / 246627	FlyBaseID:	FBgn0050463	Length:	650	Species:	Drosophila melanogaster

Alignment Length:	650	Identity:	255/650 - (39%)
Similarity:	338/650 - (52%)	Gaps:	104/650 - (16%)

- Green bases have known domain annotations that are detailed below.

Mouse     2 RRRSR---MLLCFAL-LWVLGIAYYMY---------------SGGGSALAAGG------------ 35
            ||||.   .|:.||| :|.. ||:.:|               ||.|||...||
  Fly     6 RRRSTTIVKLVAFALAIWFC-IAFLVYTDDTRRRAAQEGAGASGAGSAPGVGGGAGGLGDPIALA 69

Mouse    36 -----------------GGAGRKGDWNDID-----SIKKKDLHHSRGDEKAQGVETLPP----GK 74
                             ||.|:|...::.|     ...|.||...|..:||.......|    .|
  Fly    70 LRNEPAGEDFGINGNVIGGGGQKQAHDEADIPPTVGKHKADLQAERMRKKAAEQPKKKPQEDSKK 134

Mouse    75 VRWPDFNQEAYVG-------------GTMVRSGQDPYARNKFNQVESDKLHMDRGIPDTRHDQCQ 126
            |..|..|.|...|             ..|.::..|.:.:|.|||..||.:.:.|.:||.|...|:
  Fly   135 VIDPPANFEENPGELGKPVRLPKEMSDEMKKAVDDGWTKNAFNQYVSDLISVHRTLPDPRDAWCK 199

Mouse   127 -RKQWRVDLPATSVVITFHNEARSALLRTVVSVLKRSPPHLIKEIILVDDYSNDP------EDGA 184
             ..::..:||.|.|:|.|||||.:.|||||.|||.|||.|||.:||||||||:.|      ||
  Fly   200 DEARYLTNLPKTDVIICFHNEAWTVLLRTVHSVLDRSPEHLIGKIILVDDYSDMPHLKRQLED-- 262

Mouse   185 LLGKIEKVRVLRNDRREGLMRSRVRGADAAQAKVLTFLDSHCECNERWLEPLLERVAEDRTRVVS 249
            ......||:::|..:||||:|:|:.||:.|::.|||:|||||||.|.||||||:|:|.:.|.||.
  Fly   263 YFAAYPKVQIIRGQKREGLIRARILGANHAKSPVLTYLDSHCECTEGWLEPLLDRIARNSTTVVC 327

Mouse   250 PIIDVINMDNFQY-----VGASADLKGGFDWNLVFKWDYMTPEQRRSRQGNPVAPIKTPMIAGGL 309
            |:||||:.:..:|     .|.:.   |||||||.|.| :..||:.|.|..:...|:.:|.:||||
  Fly   328 PVIDVISDETLEYHYRDSGGVNV---GGFDWNLQFSW-HPVPERERKRHNSTAEPVYSPTMAGGL 388

Mouse   310 FVMDKLYFEELGKYDMMMDVWGGENLEISFRVWQCGGSLEIIPCSRVGHVFRKQHPYTFPGGSGT 374
            |.:|:.:|:.||.||...|:|||||||:||:.|.|||:|||:|||.|||:|||:.||.:..|. .
  Fly   389 FSIDREFFDRLGTYDSGFDIWGGENLELSFKTWMCGGTLEIVPCSHVGHIFRKRSPYKWRSGV-N 452

Mouse   375 VFARNTRRAAEVWMDEYKHFYYAAVPSARNVPYGNIQSRLELRKKLGCKPFKWYLDNVYPELRVP 439
            |..:|:.|.||||||||..:||..:.:.:. .:|::..|.:||..|.||.|||||||:||||.:|
  Fly   453 VLKKNSVRLAEVWMDEYSQYYYHRIGNDKG-DWGDVSDRRKLRNDLKCKSFKWYLDNIYPELFIP 516

Mouse   440 DHQDIAFGALQQ----GTNCLDTLG--HFADGVVGIYECHNAGGNQEWALTKEKSVKHMDLCLTV 498
            . ..:|.|.::.    |..|||...  ......||.|.||..||||.|.|:|...::..|.||..
  Fly   517 G-DSVAHGEIRNLGYGGRTCLDAPAGKKHQKKAVGTYPCHRQGGNQYWMLSKAGEIRRDDSCLDY 580

Mouse   499 VDRSPGSLIRLQGCRENDSRQKWEQIEGNSKLRHVGSNLCLDSRTAKSGGLSVEVCGPALS-QQW 562
            .    |..:.|.||......|.|...|...:|.|..|..||....:|. .|.:|.|..:|| |||
  Fly   581 A----GKDVTLFGCHGGKGNQFWTYRENTKQLHHGTSGKCLAISESKD-KLLMEECSASLSRQQW 640

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Galnt2	NP_644678.2	Catalytic subdomain A	134..239		64/110 (58%)
		pp-GalNAc-T	138..433	CDD:133004	155/305 (51%)
		Catalytic subdomain B	299..361		36/61 (59%)
		Ricin_B_lectin	445..562	CDD:279046	40/123 (33%)
		RICIN	455..564	CDD:238092	38/110 (35%)
Pgant9	NP_001097342.1	WcaA	207..>478	CDD:223539	144/277 (52%)
		pp-GalNAc-T	213..510	CDD:133004	155/304 (51%)
		Ricin_B_lectin	521..640	CDD:279046	40/123 (33%)
		RICIN	523..642	CDD:238092	40/122 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3736
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D606683at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820