Protein Alignment HSPH1 and Hsp70Bc

DIOPT Version :9

• Sequence 1: NP_001273433.1
• Gene: HSPH1 / 10808
• HGNCID: 16969
• Length: 860
• Species: Homo sapiens
• Sequence 2: NP_650209.1
• Gene: Hsp70Bc / 48583
• FlyBaseID: FBgn0013279
• Length: 641
• Species: Drosophila melanogaster
• Alignment Length: 683
• Identity: 202/683 - (29%)
• Similarity: 326/683 - (47%)
• Gaps: 121/683 - (17%)

Human    39 SVISFGSKNRTIGVAAKNQQITHANNTVSNFKRFHGRAFNDPFIQKEKENLSYDLVPLKNGG--- 100
            |.::|....|.||..||||...:..|||.:.||..||.::||.|.::.::..:.:|  .:||
  Fly    37 SYVAFTDSERLIGDPAKNQVAMNPRNTVFDAKRLIGRKYDDPKIAEDMKHWPFKVV--SDGGKPK 99

Human   101 VGIKVMYMGEEHLFSVEQITAMLLTKLKETAENSLKKPVTDCVISVPSFFTDAERRSVLDAAQIV 165
            :|::  |.||...|:.|:|::|:|||:|||||..|.:.:||.||:||::|.|::|::..||..|.
  Fly   100 IGVE--YKGESKRFAPEEISSMVLTKMKETAEAYLGESITDAVITVPAYFNDSQRQATKDAGHIA 162

Human   166 GLNCLRLMNDMTAVALNYGIYKQDLPSLDEKPRIVVFVDMGHSAFQVSACAFNKGKL-KVLGTAF 229
            |||.||::|:.||.||.||:.|    :|..:..:::| |:|...|.||....::|.| :|..||.
  Fly   163 GLNVLRIINEPTAAALAYGLDK----NLKGERNVLIF-DLGGGTFDVSILTIDEGSLFEVRSTAG 222

Human   230 DPFLGGKNFDEKLVEHFCAEFKTKYKLDAKSKIRALLRLYQECEKLKKLMSSNSTDLPLNIECFM 294
            |..|||::||.:||.|...|||.|||.|.:|..|||.||....|:.|:.:|| ||:..:.|:...
  Fly   223 DTHLGGEDFDNRLVTHLAEEFKRKYKKDLRSNPRALRRLRTAAERAKRTLSS-STEATIEIDALF 286

Human   295 NDKDVSGKMNRSQFEELCAELLQKIEVPLYSLLEQTHLKVEDVSAVEIVGGATRIPAVKERIAKF 359
            ..:|...|::|::||||||:|.:....|:...|....:....:..:.:|||:||||.|:..:.:|
  Fly   287 EGQDFYTKVSRARFEELCADLFRNTLQPVEKALNDAKMDKGQIHDIVLVGGSTRIPKVQSLLQEF 351

Human   360 F-GKDISTTLNADEAVARGCALQCAILS--PAFKVREFSVTDAVPFPISLIWNHDSEDTEG--VH 419
            | ||:::.::|.|||||.|.|:|.||||  .:.|:::..:.|..|..:.:       :|.|  :.
  Fly   352 FHGKNLNLSINPDEAVAYGAAVQAAILSGDQSGKIQDVLLVDVAPLSLGI-------ETAGGVMT 409

Human   420 EVFSRNHAAPFSKVLTFLRRGPFELEAFYSDPQGVPYPEAKIGRFVVQNVSAQ-KDGEKSRVKVK 483
            ::..||...|..:..||         :.|||.|              ..||.| .:||::..|
  Fly   410 KLIERNCRIPCKQTKTF---------STYSDNQ--------------PGVSIQVYEGERAMTK-- 449

Human   484 VRVNTHGIFTISTASMVEKVPTEENEMSSEADMECLNQRPPENPDTDKNVQQDNSEAGTQPQVQT 548
                                                                ||:..||
  Fly   450 ----------------------------------------------------DNNALGT------ 456

Human   549 DAQQTSQSPPSPELTSEENKIPDADKANEKKVDQPPEAKKPKIKVVNVELPIEANLVWQLGKDLL 613
              ...|..||:|....:.....|.| ||........|....|.|.:.::     |...:|.:..:
  Fly   457 --FDLSGIPPAPRGVPQIEVTFDLD-ANGILNVSAKEMSTGKAKNITIK-----NDKGRLSQAEI 513

Human   614 NMYIETEGKMIMQDKLEKERNDAKNAVEEYVYEFRDKL-CGPYEKFICEQDHQNFLRLLTETEDW 677
            :..:....|...:|:..::|..::||:|.||:..:..: ..|..| :.|.|..:.|....||..|
  Fly   514 DRMVNEAEKYADEDEKHRQRITSRNALESYVFNVKQSVEQAPAGK-LDEADKNSVLDKCNETIRW 577

Human   678 LYEEGEDQAKQAYVDKLEELMKIGTPVKVRFQE 710
            | :......|:.:..|:|||.:..:|:..:..:
  Fly   578 L-DSNTTAEKEEFDHKMEELTRHCSPIMTKMHQ 609

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HSPH1	NP_001273433.1	NBD_sugar-kinase_HSP70_actin	39..386	CDD:327376	140/351 (40%)
Hsp70Bc	NP_650209.1	PTZ00009	2..641	CDD:240227	202/683 (30%)
		HSPA1-2_6-8-like_NBD	3..379	CDD:212675	140/351 (40%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810