Protein Alignment HSPH1 and Hsp70Aa

DIOPT Version :10

• Sequence 1: NP_001273433.1
• Gene: HSPH1 / 10808
• HGNCID: 16969
• Length: 860
• Species: Homo sapiens
• Sequence 2: NP_731651.1
• Gene: Hsp70Aa / 48581
• FlyBaseID: FBgn0013275
• Length: 642
• Species: Drosophila melanogaster
• Alignment Length: 683
• Identity: 201/683 - (29%)
• Similarity: 325/683 - (47%)
• Gaps: 121/683 - (17%)

Human    39 SVISFGSKNRTIGVAAKNQQITHANNTVSNFKRFHGRAFNDPFIQKEKENLSYDLVPLKNGG--- 100
            |.::|....|.||..||||...:..|||.:.||..||.::||.|.::.::..:.:|  .:||
  Fly    37 SYVAFTDSERLIGDPAKNQVAMNPRNTVFDAKRLIGRKYDDPKIAEDMKHWPFKVV--SDGGKPK 99

Human   101 VGIKVMYMGEEHLFSVEQITAMLLTKLKETAENSLKKPVTDCVISVPSFFTDAERRSVLDAAQIV 165
            :|::  |.||...|:.|:|::|:|||:|||||..|.:.:||.||:||::|.|::|::..||..|.
  Fly   100 IGVE--YKGESKRFAPEEISSMVLTKMKETAEAYLGESITDAVITVPAYFNDSQRQATKDAGHIA 162

Human   166 GLNCLRLMNDMTAVALNYGIYKQDLPSLDEKPRIVVFVDMGHSAFQVSACAFNKGKL-KVLGTAF 229
            |||.||::|:.||.||.||:.|    :|..:..:::| |:|...|.||....::|.| :|..||.
  Fly   163 GLNVLRIINEPTAAALAYGLDK----NLKGERNVLIF-DLGGGTFDVSILTIDEGSLFEVRSTAG 222

Human   230 DPFLGGKNFDEKLVEHFCAEFKTKYKLDAKSKIRALLRLYQECEKLKKLMSSNSTDLPLNIECFM 294
            |..|||::||.:||.|...|||.|||.|.:|..|||.||....|:.|:.:|| ||:..:.|:...
  Fly   223 DTHLGGEDFDNRLVTHLADEFKRKYKKDLRSNPRALRRLRTAAERAKRTLSS-STEATIEIDALF 286

Human   295 NDKDVSGKMNRSQFEELCAELLQKIEVPLYSLLEQTHLKVEDVSAVEIVGGATRIPAVKERIAKF 359
            ..:|...|::|::||||||:|.:....|:...|....:....:..:.:|||:||||.|:..:..|
  Fly   287 EGQDFYTKVSRARFEELCADLFRNTLQPVEKALNDAKMDKGQIHDIVLVGGSTRIPKVQSLLQDF 351

Human   360 F-GKDISTTLNADEAVARGCALQCAILS--PAFKVREFSVTDAVPFPISLIWNHDSEDTEG--VH 419
            | ||:::.::|.|||||.|.|:|.||||  .:.|:::..:.|..|..:.:       :|.|  :.
  Fly   352 FHGKNLNLSINPDEAVAYGAAVQAAILSGDQSGKIQDVLLVDVAPLSLGI-------ETAGGVMT 409

Human   420 EVFSRNHAAPFSKVLTFLRRGPFELEAFYSDPQGVPYPEAKIGRFVVQNVSAQ-KDGEKSRVKVK 483
            ::..||...|..:..||         :.|:|.|              ..||.| .:||::..|
  Fly   410 KLIERNCRIPCKQTKTF---------STYADNQ--------------PGVSIQVYEGERAMTK-- 449

Human   484 VRVNTHGIFTISTASMVEKVPTEENEMSSEADMECLNQRPPENPDTDKNVQQDNSEAGTQPQVQT 548
                                                                ||:..||
  Fly   450 ----------------------------------------------------DNNALGT------ 456

Human   549 DAQQTSQSPPSPELTSEENKIPDADKANEKKVDQPPEAKKPKIKVVNVELPIEANLVWQLGKDLL 613
              ...|..||:|....:.....|.| ||........|....|.|.:.::     |...:|.:..:
  Fly   457 --FDLSGIPPAPRGVPQIEVTFDLD-ANGILNVSAKEMSTGKAKNITIK-----NDKGRLSQAEI 513

Human   614 NMYIETEGKMIMQDKLEKERNDAKNAVEEYVYEFRDKL-CGPYEKFICEQDHQNFLRLLTETEDW 677
            :..:....|...:|:..::|..::||:|.||:..:..: ..|..| :.|.|..:.|....:|..|
  Fly   514 DRMVNEAEKYADEDEKHRQRITSRNALESYVFNVKQAVEQAPAGK-LDEADKNSVLDKCNDTIRW 577

Human   678 LYEEGEDQAKQAYVDKLEELMKIGTPVKVRFQE 710
            | :......|:.:..|||||.:..:|:..:..:
  Fly   578 L-DSNTTAEKEEFDHKLEELTRHCSPIMTKMHQ 609

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HSPH1	NP_001273433.1	ASKHA_NBD_HSP70_HSPH1	39..383	CDD:466845	138/348 (40%)
Hsp70Aa	NP_731651.1	PTZ00009	2..642	CDD:240227	201/683 (29%)