Protein Alignment HSPH1 and Hsc70-4

DIOPT Version :10

• Sequence 1: NP_001273433.1
• Gene: HSPH1 / 10808
• HGNCID: 16969
• Length: 860
• Species: Homo sapiens
• Sequence 2: NP_524356.1
• Gene: Hsc70-4 / 41840
• FlyBaseID: FBgn0266599
• Length: 651
• Species: Drosophila melanogaster
• Alignment Length: 694
• Identity: 202/694 - (29%)
• Similarity: 312/694 - (44%)
• Gaps: 133/694 - (19%)

Human    39 SVISFGSKNRTIGVAAKNQQITHANNTVSNFKRFHGRAFNDPFIQKEKENLSYDLVPLKNGGVGI 103
            |.::|....|.||.|||||...:...|:.:.||..||.|:|..:|.:.::..:::|. .:|...|
  Fly    40 SYVAFTDTERLIGDAAKNQVAMNPTQTIFDAKRLIGRKFDDAAVQSDMKHWPFEVVS-ADGKPKI 103

Human   104 KVMYMGEEHLFSVEQITAMLLTKLKETAENSLKKPVTDCVISVPSFFTDAERRSVLDAAQIVGLN 168
            :|.|..|:..|..|:|::|:|||:|||||..|.|.||:.||:||::|.|::|::..||..|.|||
  Fly   104 EVTYKDEKKTFFPEEISSMVLTKMKETAEAYLGKTVTNAVITVPAYFNDSQRQATKDAGTIAGLN 168

Human   169 CLRLMNDMTAVALNYGIYKQDLPSLDEK---PRIVVFVDMGHSAFQVSACAFNKGKLKVLGTAFD 230
            .||::|:.||.|:.||        ||:|   .|.|:..|:|...|.||..:.:.|..:|..||.|
  Fly   169 VLRIINEPTAAAIAYG--------LDKKAVGERNVLIFDLGGGTFDVSILSIDDGIFEVKSTAGD 225

Human   231 PFLGGKNFDEKLVEHFCAEFKTKYKLDAKSKIRALLRLYQECEKLKKLMSSNSTDLPLNIECFMN 295
            ..|||::||.:||.||..|||.|:|.|..:..|||.||...||:.|:.:|| ||...:.|:....
  Fly   226 THLGGEDFDNRLVTHFVQEFKRKHKKDLTTNKRALRRLRTACERAKRTLSS-STQASIEIDSLFE 289

Human   296 DKDVSGKMNRSQFEELCAELLQKIEVPLYSLLEQTHLKVEDVSAVEIVGGATRIPAVKERIAKFF 360
            ..|....:.|::||||.|:|.:....|:...|....|....:..:.:|||:||||.|:..:...|
  Fly   290 GTDFYTSITRARFEELNADLFRSTMDPVEKALRDAKLDKSVIHDIVLVGGSTRIPKVQRLLQDLF 354

Human   361 -GKDISTTLNADEAVARGCALQCAIL--SPAFKVREFSVTDAVPFPISLIWNHDSEDTEGVHEV- 421
             ||:::.::|.|||||.|.|:|.|||  ..:.:|::..:.|..|..:.:      |...||..|
  Fly   355 NGKELNKSINPDEAVAYGAAVQAAILHGDKSQEVQDLLLLDVTPLSLGI------ETAGGVMSVL 413

Human   422 FSRNHAAPFSKVLTFLRRGPFELEAFYSDPQGVPYPEAKIGRFVVQNVSAQKDGEKSRVKVKVRV 486
            ..||...|..:..||         ..|||.|    |...|..:         :||::.
  Fly   414 IKRNTTIPTKQTQTF---------TTYSDNQ----PGVLIQVY---------EGERAM------- 449

Human   487 NTHGIFTISTASMVEKVPTEENEMSSEADMECLNQRPPENPDTDKNVQQDNSEAGTQPQVQT--- 548
                              |::|.:..:.::..:       |...:.|          ||::.
  Fly   450 ------------------TKDNNLLGKFELSGI-------PPAPRGV----------PQIEVTFD 479

Human   549 -DAQQTSQSPPSPELTSEENKIP-DADKANEKKVDQPPEAKKPKIKVVNVELPIEANLVWQLGKD 611
             ||............|::||||. ..||....|                              :|
  Fly   480 IDANGILNVTALERSTNKENKITITNDKGRLSK------------------------------ED 514

Human   612 LLNMYIETEGKMIMQDKLEKERNDAKNAVEEYVYEFR-----DKLCGPYEKFICEQDHQNFLRLL 671
            :..|..|.| |...:|:.:||...|||.:|.|.:..:     |.|    :..|.:.|....|...
  Fly   515 IERMVNEAE-KYRNEDEKQKETIAAKNGLESYCFNMKATLDEDNL----KTKISDSDRTTILDKC 574

Human   672 TETEDWLYEEGEDQAKQAYVDKLEELMKIGTPVKVRFQEAEERP 715
            .||..|| :..:...|:.|..:.:||..:..|:..:..:....|
  Fly   575 NETIKWL-DANQLADKEEYEHRQKELEGVCNPIITKLYQGAGFP 617

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HSPH1	NP_001273433.1	ASKHA_NBD_HSP70_HSPH1	39..383	CDD:466845	135/347 (39%)
Hsc70-4	NP_524356.1	PTZ00009	1..612	CDD:240227	201/687 (29%)