DRSC/TRiP Functional Genomics Resources

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Protein Alignment HSPH1 and Hsc70-4

DIOPT Version :9

Sequence 1:NP_001273433.1 Gene:HSPH1 / 10808 HGNCID:16969 Length:860 Species:Homo sapiens
Sequence 2:NP_001262586.1 Gene:Hsc70-4 / 41840 FlyBaseID:FBgn0266599 Length:651 Species:Drosophila melanogaster


Alignment Length:694 Identity:202/694 - (29%)
Similarity:312/694 - (44%) Gaps:133/694 - (19%)


- Green bases have known domain annotations that are detailed below.


Human    39 SVISFGSKNRTIGVAAKNQQITHANNTVSNFKRFHGRAFNDPFIQKEKENLSYDLVPLKNGGVGI 103
            |.::|....|.||.|||||...:...|:.:.||..||.|:|..:|.:.::..:::|. .:|...|
  Fly    40 SYVAFTDTERLIGDAAKNQVAMNPTQTIFDAKRLIGRKFDDAAVQSDMKHWPFEVVS-ADGKPKI 103

Human   104 KVMYMGEEHLFSVEQITAMLLTKLKETAENSLKKPVTDCVISVPSFFTDAERRSVLDAAQIVGLN 168
            :|.|..|:..|..|:|::|:|||:|||||..|.|.||:.||:||::|.|::|::..||..|.|||
  Fly   104 EVTYKDEKKTFFPEEISSMVLTKMKETAEAYLGKTVTNAVITVPAYFNDSQRQATKDAGTIAGLN 168

Human   169 CLRLMNDMTAVALNYGIYKQDLPSLDEK---PRIVVFVDMGHSAFQVSACAFNKGKLKVLGTAFD 230
            .||::|:.||.|:.||        ||:|   .|.|:..|:|...|.||..:.:.|..:|..||.|
  Fly   169 VLRIINEPTAAAIAYG--------LDKKAVGERNVLIFDLGGGTFDVSILSIDDGIFEVKSTAGD 225

Human   231 PFLGGKNFDEKLVEHFCAEFKTKYKLDAKSKIRALLRLYQECEKLKKLMSSNSTDLPLNIECFMN 295
            ..|||::||.:||.||..|||.|:|.|..:..|||.||...||:.|:.:|| ||...:.|:....
  Fly   226 THLGGEDFDNRLVTHFVQEFKRKHKKDLTTNKRALRRLRTACERAKRTLSS-STQASIEIDSLFE 289

Human   296 DKDVSGKMNRSQFEELCAELLQKIEVPLYSLLEQTHLKVEDVSAVEIVGGATRIPAVKERIAKFF 360
            ..|....:.|::||||.|:|.:....|:...|....|....:..:.:|||:||||.|:..:...|
  Fly   290 GTDFYTSITRARFEELNADLFRSTMDPVEKALRDAKLDKSVIHDIVLVGGSTRIPKVQRLLQDLF 354

Human   361 -GKDISTTLNADEAVARGCALQCAIL--SPAFKVREFSVTDAVPFPISLIWNHDSEDTEGVHEV- 421
             ||:::.::|.|||||.|.|:|.|||  ..:.:|::..:.|..|..:.:      |...||..| 
  Fly   355 NGKELNKSINPDEAVAYGAAVQAAILHGDKSQEVQDLLLLDVTPLSLGI------ETAGGVMSVL 413

Human   422 FSRNHAAPFSKVLTFLRRGPFELEAFYSDPQGVPYPEAKIGRFVVQNVSAQKDGEKSRVKVKVRV 486
            ..||...|..:..||         ..|||.|    |...|..:         :||::.       
  Fly   414 IKRNTTIPTKQTQTF---------TTYSDNQ----PGVLIQVY---------EGERAM------- 449

Human   487 NTHGIFTISTASMVEKVPTEENEMSSEADMECLNQRPPENPDTDKNVQQDNSEAGTQPQVQT--- 548
                              |::|.:..:.::..:       |...:.|          ||::.   
  Fly   450 ------------------TKDNNLLGKFELSGI-------PPAPRGV----------PQIEVTFD 479

Human   549 -DAQQTSQSPPSPELTSEENKIP-DADKANEKKVDQPPEAKKPKIKVVNVELPIEANLVWQLGKD 611
             ||............|::||||. ..||....|                              :|
  Fly   480 IDANGILNVTALERSTNKENKITITNDKGRLSK------------------------------ED 514

Human   612 LLNMYIETEGKMIMQDKLEKERNDAKNAVEEYVYEFR-----DKLCGPYEKFICEQDHQNFLRLL 671
            :..|..|.| |...:|:.:||...|||.:|.|.:..:     |.|    :..|.:.|....|...
  Fly   515 IERMVNEAE-KYRNEDEKQKETIAAKNGLESYCFNMKATLDEDNL----KTKISDSDRTTILDKC 574

Human   672 TETEDWLYEEGEDQAKQAYVDKLEELMKIGTPVKVRFQEAEERP 715
            .||..|| :..:...|:.|..:.:||..:..|:..:..:....|
  Fly   575 NETIKWL-DANQLADKEEYEHRQKELEGVCNPIITKLYQGAGFP 617

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HSPH1NP_001273433.1 NBD_sugar-kinase_HSP70_actin 39..386 CDD:327376 138/352 (39%)
Hsc70-4NP_001262586.1 PTZ00009 1..612 CDD:240227 201/687 (29%)
HSPA1-2_6-8-like_NBD 6..381 CDD:212675 137/350 (39%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0443
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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