DRSC/TRiP Functional Genomics Resources

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Protein Alignment HSPH1 and Hsc70-2

DIOPT Version :9

Sequence 1:NP_001273433.1 Gene:HSPH1 / 10808 HGNCID:16969 Length:860 Species:Homo sapiens
Sequence 2:NP_524339.1 Gene:Hsc70-2 / 41609 FlyBaseID:FBgn0001217 Length:633 Species:Drosophila melanogaster


Alignment Length:699 Identity:197/699 - (28%)
Similarity:320/699 - (45%) Gaps:134/699 - (19%)


- Green bases have known domain annotations that are detailed below.


Human    29 GTW-----------RGRWRRRSVISFGSKNRTIGVAAKNQQITHANNTVSNFKRFHGRAFNDPFI 82
            |.|           :|.....|.::|....|.||..||||...:|.|||.:.||..||.|:|..|
  Fly    19 GVWQNSKVEIIANDQGNRTTPSYVAFNETERLIGDPAKNQVAMNAKNTVFDAKRLIGRKFDDKKI 83

Human    83 QKEKENLSYDLVPLKNGGVGIKVMYMGEEHLFSVEQITAMLLTKLKETAENSLKKPVTDCVISVP 147
            |::.:...:.::..| |...|:|.:.||...|:.|:|::|:|||::|.||..|...|.|.|::||
  Fly    84 QEDLKLWPFKVINEK-GKPKIEVEFKGERKRFAPEEISSMVLTKMREIAEVYLGGKVKDAVVTVP 147

Human   148 SFFTDAERRSVLDAAQIVGLNCLRLMNDMTAVALNYGIYKQDLPSLDEKPRIVVFVDMGHSAFQV 212
            ::|.|::|::..||..|.|||.||::|:.||.||.||:.|    :|..:..:::| |:|...|.|
  Fly   148 AYFNDSQRQATKDAGSIAGLNVLRIINEPTAAALAYGLDK----NLKGERNVLIF-DLGGGTFDV 207

Human   213 SACAFNKGKL-KVLGTAFDPFLGGKNFDEKLVEHFCAEFKTKYKLDAKSKIRALLRLYQECEKLK 276
            |..:.::|.| :|..||.|..|||::||.:||.||..|||.|:|.|.|...|||.||...||:.|
  Fly   208 SVLSIDEGSLFEVKATAGDTHLGGEDFDNRLVNHFAEEFKRKHKSDIKGNARALRRLRTACERAK 272

Human   277 KLMSSNSTDLPLNIECFMNDKDVSGKMNRSQFEELCAELLQKIEVPLYSLLEQTHLKVEDVSAVE 341
            :.:|| ||:..|.|:......|...|::|::||||..:|.:....|:...|....:..:.:..|.
  Fly   273 RTLSS-STEASLEIDALHEGIDFYSKISRARFEELNMDLFRSTMQPVERALSDAKMDKKAIHDVV 336

Human   342 IVGGATRIPAVKERIAKFF-GKDISTTLNADEAVARGCALQCAILS--PAFKVREFSVTDAVPFP 403
            :|||:||||.:::.:...| ||.::.::|.|||||.|.|:|.|||:  .:.::::..:.|..|..
  Fly   337 LVGGSTRIPKIQKLLQDLFGGKQLNLSINPDEAVAYGAAVQAAILTGVGSSQIQDLLLVDVAPLS 401

Human   404 ISLIWNHDSEDTEG--VHEVFSRNHAAPFSKVLTFLRRGPFELEAFYSDPQGVPYPEAKIGRFVV 466
            :.:       :|.|  :..:..||...|..:...|         ..|||.|..            
  Fly   402 LGI-------ETAGGVMTNLVERNARIPCKQQQIF---------TTYSDNQNA------------ 438

Human   467 QNVSAQ-KDGEKSRVKVKVRVNTHGIFTISTASMVEKVPTEENEMSSEADMECLNQRPPENPDTD 530
              |:.| .:||::..|..   |..|.|.::.   :...|....::....|:         |.|..
  Fly   439 --VTIQVYEGERAMTKDN---NLLGTFNLTG---IPPAPRGVPQIEVAFDL---------NADGI 486

Human   531 KNVQ-QDNSEAGTQPQVQTDAQQTSQSPPSPELTSEENKIP---DADKANEKKVDQP-PEAKKPK 590
            .||. :|||                        |.:..||.   |..:.::.::|:. .||:|.|
  Fly   487 LNVNAKDNS------------------------TGKSEKITISNDKGRLSKAEIDRMLSEAEKYK 527

Human   591 IKVVNVELPIEANLVWQLGKDLLNMYIETEGKMIMQDKLEKERNDAKNAVEEYVYEFRDKLCGPY 655
            :                                  :|..::||..:||.:|.|:|..|..:....
  Fly   528 V----------------------------------EDDRQRERVQSKNNLEAYIYACRQAVDDAP 558

Human   656 EKFICEQDHQNFLRLLTETEDWLYEEGEDQAKQAYVDKLEELMKIGTPV 704
            ...:.|.:........:....|| ::.....|:.:...|:|..:|.||:
  Fly   559 SGVLSETERSKVRDKCSSEASWL-DKNSLAEKEEFESHLKECQRICTPI 606

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HSPH1NP_001273433.1 NBD_sugar-kinase_HSP70_actin 39..386 CDD:327376 137/348 (39%)
Hsc70-2NP_524339.1 PTZ00009 1..632 CDD:240227 197/699 (28%)
HSPA1-2_6-8-like_NBD 6..382 CDD:212675 140/369 (38%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0443
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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