DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment HSPH1 and Hsc70Cb

DIOPT Version :9

Sequence 1:	NP_001273433.1	Gene:	HSPH1 / 10808	HGNCID:	16969	Length:	860	Species:	Homo sapiens
Sequence 2:	NP_001189103.1	Gene:	Hsc70Cb / 39557	FlyBaseID:	FBgn0026418	Length:	836	Species:	Drosophila melanogaster

Alignment Length:	849	Identity:	348/849 - (40%)
Similarity:	507/849 - (59%)	Gaps:	43/849 - (5%)

- Green bases have known domain annotations that are detailed below.

Human    16 ESFQKAREEGSGSGTWRGRWRRR---SVISFGSKNRTIGVAAKNQQITHANNTVSNFKRFHGRAF 77
            ||...|.....|..|....:..|   |.::|..|.|.|||||||||:|:..|||..|||..||.|
  Fly    11 ESCYVAAARSGGIETLANDYSLRATPSFVAFDGKKRIIGVAAKNQQVTNMKNTVGGFKRLLGRKF 75

Human    78 NDPFIQKEKENLSYDLVPLKNGGVGIKVMYMGEEHLFSVEQITAMLLTKLKETAENSLKKPVTDC 142
            |||.:|.|..::...:....:|.:||||.|:||:..|..||:||||.||||||:..:::..|.||
  Fly    76 NDPHVQHELTSIPARVEARGDGSIGIKVNYLGEDQHFGPEQLTAMLFTKLKETSAAAMQTQVNDC 140

Human   143 VISVPSFFTDAERRSVLDAAQIVGLNCLRLMNDMTAVALNYGIYKQDLPSLDEKPRIVVFVDMGH 207
            ||:.|.|||:|||:::||||||.|||.|||||:.||.||.||.||.||  .::|||.|:|||.||
  Fly   141 VIACPVFFTNAERKALLDAAQIAGLNVLRLMNETTATALAYGFYKNDL--FEDKPRNVIFVDFGH 203

Human   208 SAFQVSACAFNKGKLKVLGTAFDPFLGGKNFDEKLVEHFCAEFKTKYKLDAKSKIRALLRLYQEC 272
            |:.|.|||||.|||||:|.:.:|. :||::.|..|.::|..||:.:||::||:..||.|||..|.
  Fly   204 SSLQASACAFTKGKLKMLASTWDQ-IGGRDIDLALGDYFAKEFQERYKINAKTNARANLRLLTEI 267

Human   273 EKLKKLMSSNSTDLPLNIECFMNDKDVSGKMNRSQFEELCAELLQKIEVPLYSLLEQTHLKVEDV 337
            |||||.||:|||.||||||||::|.|||..|.|||.|||||.:||::|.....||.::.|:::|:
  Fly   268 EKLKKQMSANSTKLPLNIECFLDDIDVSSSMQRSQMEELCAPVLQRVEQTFKRLLAESKLQLDDI 332

Human   338 SAVEIVGGATRIPAVKERIAKFFGKDISTTLNADEAVARGCALQCAILSPAFKVREFSVTDAVPF 402
            .:||||||::|||:||:.|.:.|.|..|||||.||||:||.||||||:|||.:||||.|||...:
  Fly   333 HSVEIVGGSSRIPSVKQLIEQVFNKPASTTLNQDEAVSRGAALQCAIMSPAVRVREFGVTDIQNY 397

Human   403 PISLIWNHDSEDTEGVHEVFSRNHAAPFSKVLTFLRRGPFELEAFYSDPQGVPYPEAKIGRFVVQ 467
            .:.::|:.:.....|..|:|.:.||:|||::||..|:|||.:...|.  |.||||:..||.:.|:
  Fly   398 AVKVLWDSEGSAAPGEIEIFPQYHASPFSRLLTINRKGPFNVSIVYG--QQVPYPDQTIGVWKVK 460

Human   468 NVSAQKDGEKSRVKVKVRVNTHGIFTISTASMVEKVPTEENEMSSEADMECLNQRPPENPDTDKN 532
            :|...:.||...||:|||:|.:||..||:|::|||  .|..|.::.|:.....::|.:..:....
  Fly   461 DVKPTERGEGQDVKLKVRINNNGIVLISSATLVEK--KEAEEAAAAAEQAASEEKPGDQTNNTGE 523

Human   533 VQQDNSEAGTQPQVQTDAQQTSQSPPSPELTSEENKIPDADKANEKKVDQPPEAKKPKIKVVNVE 597
            ......||..:.  :.|...::.|.|..:..::..|......|::||     :|.|.      .|
  Fly   524 PADGQQEAYCEN--EDDNNTSTASSPGGQGWAQRVKGWFGSGADKKK-----KASKA------TE 575

Human   598 LPIEANLVWQLGKDLLNMYIETEGKMIMQDKLEKERNDAKNAVEEYVYEFRDKL-CGPYEKFICE 661
            ||:|.........||.| |.:.|.|||..|:.|.||.|||||:||:||:.|:|| .||:|:::.|
  Fly   576 LPLECTTHGFSPVDLSN-YTQQESKMIGNDQKETERIDAKNALEEFVYDMRNKLQGGPFERYVVE 639

Human   662 QDHQNFLRLLTETEDWLYEEGEDQAKQAYVDKLEELMKIGTPVKVRFQEAEERPKMFEELGQRLQ 726
            .:.:..:..|.:.|:||||:|||..:..|..:|:.|.:...|:|:|..:.|:.|..|:||...:.
  Fly   640 AEREKIVSQLNDLENWLYEDGEDCERDIYTSRLQALHQKTDPIKLRASDYEQGPAAFDELKNSIA 704

Human   727 HYAKIAADFRNKDEKYNHIDESEMKKVEKSVNEVMEWMNNVMNAQAKKSLDQDPVVRAQEIKTKI 791
            ......|:||....||:|:.|:|...:.::.::...|::..:....:.....|..|:...::.::
  Fly   705 IARLAVAEFRKGVPKYDHLTETEFINISETADKAQSWLDANLPKFTQSPRTADSPVQISAVRQEV 769

Human   792 KELNNTCEPVVTQPKPKIESPKLERTPNGPNIDKKEEDLEDKNNFGAEPPHQNGECYPNEKNSVN 856
            :.||:....|:.:.||| .:|....||      .|:|...::|  |.||...:|:         .
  Fly   770 QTLNSCVSSVINRAKPK-PTPAKTATP------PKDEANAEQN--GGEPAANSGD---------K 816

Human   857 MDLD 860
            ||:|
  Fly   817 MDVD 820

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HSPH1	NP_001273433.1	NBD_sugar-kinase_HSP70_actin	39..386	CDD:327376	194/346 (56%)
Hsc70Cb	NP_001189103.1	HSPA4_like_NDB	2..381	CDD:212670	200/372 (54%)
Hsc70Cb	NP_001189103.1	HSP70	3..682	CDD:278441	310/691 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165156589
Domainoid	1	1.000	603	1.000	Domainoid score	I195
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	671	1.000	Inparanoid score	I739
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54058
OrthoDB	1	1.010	-	-		D285748at33208
OrthoFinder	1	1.000	-	-		FOG0001023
OrthoInspector	1	1.000	-	-		otm40306
orthoMCL	1	0.900	-	-		OOG6_100680
Panther	1	1.100	-	-	O	PTHR45639
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R574
SonicParanoid	1	1.000	-	-		X684
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.800