Protein Alignment HSPH1 and Hsc70-1

DIOPT Version :9

• Sequence 1: NP_001273433.1
• Gene: HSPH1 / 10808
• HGNCID: 16969
• Length: 860
• Species: Homo sapiens
• Sequence 2: NP_524063.1
• Gene: Hsc70-1 / 39542
• FlyBaseID: FBgn0001216
• Length: 641
• Species: Drosophila melanogaster
• Alignment Length: 710
• Identity: 195/710 - (27%)
• Similarity: 312/710 - (43%)
• Gaps: 164/710 - (23%)

Human    39 SVISFGSKNRTIGVAAKNQQITHANNTVSNFKRFHGRAFNDPFIQKEKENLSYDLVPLKNGGVGI 103
            |.::|....|.||.|||||...:.|||:.:.||..||.|:|..:|.:.::..:: |..:||...|
  Fly    40 SYVAFTESERLIGDAAKNQVAMNPNNTIFDAKRLIGRRFDDATVQSDMKHWPFE-VFAENGKPRI 103

Human   104 KVMYMGEEHLFSVEQITAMLLTKLKETAENSLKKPVTDCVISVPSFFTDAERRSVLDAAQIVGLN 168
            :|.|.||...|..|::::|:|||::||||..|...|||.|::||::|.|::|::..||..|.|||
  Fly   104 RVEYKGERKSFYPEEVSSMVLTKMRETAEAYLGGTVTDAVVTVPAYFNDSQRQATKDAGAIAGLN 168

Human   169 CLRLMNDMTAVALNYGIYKQDLPSLDEKPRIVVFVDMGHSAFQVSACAFNKGKLKVLGTAFDPFL 233
            .||::|:.||.|:.||:.||     ....|.|:..|:|...|.||......|..:|..||.|..|
  Fly   169 VLRIINEPTAAAIAYGLDKQ-----GTSERNVLIFDLGGGTFDVSVLTIEDGIFEVKATAGDTHL 228

Human   234 GGKNFDEKLVEHFCAEFKTKYKLDAKSKIRALLRLYQECEKLKKLMSSNSTDLPLNIECFMNDKD 298
            ||::||.:||.||..||:.|:|.|.....|||.||...||:.|:.:|| ||...:.|:......|
  Fly   229 GGEDFDNRLVNHFVQEFQRKHKKDLGQNKRALRRLRTACERAKRTLSS-STQASIEIDSLFEGVD 292

Human   299 VSGKMNRSQFEELCAELLQKIEVPLYSLLEQTHLKVEDVSAVEIVGGATRIPAVKERIAKFF-GK 362
            ....:.|::||||..:|.:....|:...|....:....:..:.:|||:||||.|:..:..|| ||
  Fly   293 FYTSVTRARFEELNGDLFRGTMEPVAKALRDAKMDKGQIHDIVLVGGSTRIPKVQRLLQDFFNGK 357

Human   363 DISTTLNADEAVARGCALQCAIL--SPAFKVREFSVTDAVPFPISLIWNHDSEDTEG--VHEVFS 423
            :::.::|.|||||.|.|:|.|||  ..:..|::..:.|..|..:.:       :|.|  :..:..
  Fly   358 ELNKSINPDEAVAYGAAVQAAILHGDKSEAVQDLLLLDVTPLSLGI-------ETAGGVMTTLIK 415

Human   424 RNHAAPFSKVLTF--------------------LRR-----GPFELEAFYSDPQGVPYPEAKIGR 463
            ||...|..:...|                    :.|     |.|||.|....|:|||
  Fly   416 RNTTIPTKQTQIFTTYADNQPGVLIQVFEGERAMTRDNNSLGKFELSAIPPAPRGVP-------- 472

Human   464 FVVQNVSAQKDGEKSRVKVKVRVNTHGIFTISTASMVEKVPTEENEMSSEADMECLNQRPPENPD 528
                           :|:|...::.:||..::.   :||...:||.::...|...|::.     |
  Fly   473 ---------------QVEVTFDIDANGILNVTA---LEKSTGKENRITITNDKGRLSKE-----D 514

Human   529 TDKNVQQDNSEAGTQPQVQTDAQQTSQSPPSPELTSEENKIPDADKANEKKVDQPPEAKKPKIKV 593
            .::.|              .||:...|:
  Fly   515 IERMV--------------NDAEAYRQA------------------------------------- 528

Human   594 VNVELPIEANLVWQLGKDLLNMYIETEGKMIMQDKLEKERNDAKNAVEEYVYEFRDKLCGPY--E 656
                                             |:.:::|.:|||.:|.|.::.|..|...:  .
  Fly   529 ---------------------------------DEQQRDRINAKNQLESYCFQLRSTLDDEHLSS 560

Human   657 KFICEQDHQNFLRLLTETEDWLYEEGEDQAKQAYVDKLEELMKIGTPVKVR-FQEAEERP 715
            :| ...|.:...:..:||..|| :..:...:|.:..|.:||.:|.:|:..| :|.|...|
  Fly   561 RF-SPADRETIQQRSSETIAWL-DANQLAERQEFEHKQQELERICSPIITRLYQGAGMAP 618

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HSPH1	NP_001273433.1	NBD_sugar-kinase_HSP70_actin	39..386	CDD:327376	136/349 (39%)
Hsc70-1	NP_524063.1	PTZ00009	1..641	CDD:240227	195/710 (27%)
		HSPA1-2_6-8-like_NBD	6..381	CDD:212675	135/347 (39%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810