Protein Alignment HSPH1 and Hsc70-5

DIOPT Version :9

• Sequence 1: NP_001273433.1
• Gene: HSPH1 / 10808
• HGNCID: 16969
• Length: 860
• Species: Homo sapiens
• Sequence 2: NP_001286414.1
• Gene: Hsc70-5 / 36583
• FlyBaseID: FBgn0001220
• Length: 686
• Species: Drosophila melanogaster
• Alignment Length: 775
• Identity: 206/775 - (26%)
• Similarity: 325/775 - (41%)
• Gaps: 178/775 - (22%)

Human     5 AVLRGPAAHWVESFQKAREEGSGSGTWRGRWRRRSVISFGSK-NRTIGVAAKNQQITHANNTVSN 68
            ||:.|..|..:|:.:.||...|.             ::|... .|.:|:.||.|.:|::.||...
  Fly    67 AVMEGKQAKVIENAEGARTTPSH-------------VAFTKDGERLVGMPAKRQAVTNSANTFYA 118

Human    69 FKRFHGRAFNDPFIQKEKENLSYDLVPLKNGGVGIKVMYMGEEHLFSVEQITAMLLTKLKETAEN 133
            .||..||.|:||.::|:..||||.:|...||...:.   ..:..::|..||.|.:|.|:|||||.
  Fly   119 TKRLIGRRFDDPEVKKDITNLSYKVVKASNGDAWVS---STDGKVYSPSQIGAFILMKMKETAEA 180

Human   134 SLKKPVTDCVISVPSFFTDAERRSVLDAAQIVGLNCLRLMNDMTAVALNYGIYKQDLPSLDEKPR 198
            .|..||.:.|::||::|.|::|::..||.||.|||.||::|:.||.||.||:.|.:       .:
  Fly   181 YLNTPVKNAVVTVPAYFNDSQRQATKDAGQIAGLNVLRVINEPTAAALAYGMDKTE-------DK 238

Human   199 IVVFVDMGHSAFQVSACAFNKGKLKVLGTAFDPFLGGKNFDEKLVEHFCAEFKTKYKLDAKSKIR 263
            |:...|:|...|.:|.....||..:|..|..|..|||::||..:|....||||....:|.:....
  Fly   239 IIAVYDLGGGTFDISILEIQKGVFEVKSTNGDTLLGGEDFDNHIVNFLVAEFKKDSGIDIRKDNI 303

Human   264 ALLRLYQECEKLK-KLMSSNSTDLPLNIECFMND----KDVSGKMNRSQFEELCAELLQKIEVPL 323
            |:.||.:..||.| :|.||..||  :|:.....|    :.::.|:.||:.|.|..:|:::...|.
  Fly   304 AMQRLKEAAEKAKCELSSSQQTD--INLPYLTMDAAGPQHMNLKLTRSKLESLVGDLIKRTIQPC 366

Human   324 YSLLEQTHLKVEDVSAVEIVGGATRIPAVKERIAKFFGKDISTTLNADEAVARGCALQCAILSPA 388
            ...|....:...::..|.:|||.||:|.|:..:.:.||:..|.::|.|||||.|.|:|..:|  |
  Fly   367 QKALSDAEVSKSEIGEVLLVGGMTRMPKVQSTVQELFGRQPSRSVNPDEAVAVGAAVQGGVL--A 429

Human   389 FKVREFSVTDAVPFPISLIWNHDSEDTEGVH-EVFSRNHAAPFSKVLTFLRRGPFELEAFYSDPQ 452
            ..|.:..:.|..|..:.:      |...||. .:.|||...|..|...|
  Fly   430 GDVTDVLLLDVTPLSLGI------ETLGGVFTRLISRNTTIPTKKSQVF---------------- 472

Human   453 GVPYPEAKIGRFVVQNVSAQKDGEKSRVKVKVRVNTHGIFTISTASMVEKVPTEENEMSSEADME 517
                             |...||: ::|::||...             |:....:|::.....:.
  Fly   473 -----------------STASDGQ-TQVEIKVHQG-------------EREMANDNKLLGSFTLV 506

Human   518 CLNQRPPENP------DTDKN--VQQDNSEAGTQPQVQTDAQQTSQSPPSPELTSEENKIPDADK 574
            .:...|...|      |.|.|  |.....:.||..:.|. ..|:|......|:   ||.|
  Fly   507 GIPPAPRGVPQIEVVFDIDANGIVHVSAKDKGTGKEQQI-VIQSSGGLSKDEI---ENMI----- 562

Human   575 ANEKKVDQPPEAKKPK---IKVVNVELPIEANLVWQLGKDLLNMYIETEGKMIMQDKLEKERNDA 636
               ||.::...|.|.|   |::||                        :|:.|:.|
  Fly   563 ---KKAEEYATADKQKRELIEIVN------------------------QGESIVHD--------- 591

Human   637 KNAVEEYVYEFRDKLCGPYEKFICEQDHQNFLRLLT-----ETEDWLYEEGEDQAKQAYVDKLEE 696
               .|..:.||:.:|  |.|:  ||:..:....|.|     ||.|                 |||
  Fly   592 ---TETKMEEFKSQL--PAEE--CEKLKKEIADLRTLLANKETAD-----------------LEE 632

Human   697 LMKIGTPVKVRFQEAEERPKMFEELGQRLQHYAKIAADFRNKDEKYNHIDESEMKKVEKS 756
            :.|..:.::      :...|:||...:::....:..|...:.|...:.....|.||.||:
  Fly   633 VRKATSSLQ------QSSLKLFELAYKKMSAERESNAGAGSSDSSSSSDTSGEAKKEEKN 686

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HSPH1	NP_001273433.1	NBD_sugar-kinase_HSP70_actin	39..386	CDD:327376	123/352 (35%)
Hsc70-5	NP_001286414.1	dnaK	51..666	CDD:234715	200/753 (27%)
		HSPA9-like_NBD	51..428	CDD:212683	131/385 (34%)
		Syntaphilin	<566..>642	CDD:291936	26/138 (19%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900