Protein Alignment HSPH1 and Hsc70-3

DIOPT Version :9

• Sequence 1: NP_001273433.1
• Gene: HSPH1 / 10808
• HGNCID: 16969
• Length: 860
• Species: Homo sapiens
• Sequence 2: NP_001285139.1
• Gene: Hsc70-3 / 32133
• FlyBaseID: FBgn0001218
• Length: 656
• Species: Drosophila melanogaster
• Alignment Length: 826
• Identity: 195/826 - (23%)
• Similarity: 326/826 - (39%)
• Gaps: 271/826 - (32%)

Human    39 SVISF-GSKNRTIGVAAKNQQITHANNTVSNFKRFHGRAFNDPFIQKEKENLSYDLVPLKNGGVG 102
            |.::| ....|.||.|||||..|:..|||.:.||..||.::|..:|.:.:...:.:|. ||....
  Fly    65 SYVAFTADGERLIGDAAKNQLTTNPENTVFDAKRLIGREWSDTNVQHDIKFFPFKVVE-KNSKPH 128

Human   103 IKVMYMGEEHLFSVEQITAMLLTKLKETAENSLKKPVTDCVISVPSFFTDAERRSVLDAAQIVGL 167
            |.|.......:|:.|:|:||:|.|:|||||..|.|.||..|::||::|.||:|::..||..|.||
  Fly   129 ISVDTSQGAKVFAPEEISAMVLGKMKETAEAYLGKKVTHAVVTVPAYFNDAQRQATKDAGVIAGL 193

Human   168 NCLRLMNDMTAVALNYGIYKQDLPSLDEKPRIVVFVDMGHSAFQVSACAFNKGKLKVLGTAFDPF 232
            ..:|::|:.||.|:.||:.|::    .|| .::|| |:|...|.||....:.|..:|:.|..|..
  Fly   194 QVMRIINEPTAAAIAYGLDKKE----GEK-NVLVF-DLGGGTFDVSLLTIDNGVFEVVATNGDTH 252

Human   233 LGGKNFDEKLVEHFCAEFKTKYKLDAKSKIRALLRLYQECEKLKKLMSSNSTDLPLNIECFMNDK 297
            |||::||:::::||...:|.|...|.:...||:.:|.:|.||.|:.: |.|..:.:.||.|....
  Fly   253 LGGEDFDQRVMDHFIKLYKKKKGKDIRKDNRAVQKLRREVEKAKRAL-SGSHQVRIEIESFFEGD 316

Human   298 DVSGKMNRSQFEELCAELLQKIEVPLYSLLEQTHLKVEDVSAVEIVGGATRIPAVKERIAKFF-G 361
            |.|..:.|::||||..:|.:....|:..:||...:..:||..:.:|||:||||.|::.:..|| |
  Fly   317 DFSETLTRAKFEELNLDLFRSTLKPVQKVLEDADMNKKDVHEIVLVGGSTRIPKVQQLVKDFFGG 381

Human   362 KDISTTLNADEAVARGCALQCAILSPAFKVREFSVTDAVPFPISLIWNHDSEDTEGV-HEVFSRN 425
            |:.|..:|.|||||.|.|:|..:||.........:.|..|..:.:      |...|| .::..||
  Fly   382 KEPSRGINPDEAVAYGAAVQAGVLSGEQDTDAIVLLDVNPLTMGI------ETVGGVMTKLIPRN 440

Human   426 HAAPFSKVLTFLRR-------------------------GPFELEAFYSDPQGVPYPEAKIGRFV 465
            ...|..|...|...                         |.|:|......|:|:|
  Fly   441 TVIPTKKSQVFSTASDNQHTVTIQVYEGERPMTKDNHLLGKFDLTGIPPAPRGIP---------- 495

Human   466 VQNVSAQKDGEKSRVKVKVRVNTHGIFTISTASMVEKVPTEENEMSSEADMECLNQRPPENPDTD 530
                         :::|...::.:||..:|.
  Fly   496 -------------QIEVSFEIDANGILQVSA---------------------------------- 513

Human   531 KNVQQDNSEAGTQPQVQTDAQQTSQSPPSPELTSEENKIPDADKANEKKVDQPPEAKKPKIKVVN 595
                 ::...|.:.::              .:|:::|::...|
  Fly   514 -----EDKGTGNKEKI--------------VITNDQNRLTPED---------------------- 537

Human   596 VELPIEANLVWQLGKDLLNMYIETEGKMIMQDKLEKERNDAKNAVEEYVYEFRDKLCGPYEKFIC 660
                             ::..|....|...:||..|||.:::|.:|.|.|..::::
  Fly   538 -----------------IDRMIRDAEKFADEDKKLKERVESRNELESYAYSLKNQI--------- 576

Human   661 EQDHQNFLRLLTETEDWLYEEGEDQAKQAYVDKLEELMKIGTPVKVRFQEAEERPKMFEELGQRL 725
                                          .||                         ::||.:|
  Fly   577 ------------------------------GDK-------------------------DKLGAKL 586

Human   726 QHYAKIAADFRNKDEKYNHIDESEMKKVEKSVNEVMEWMNNVMNAQAKKSLDQDPVVRAQEIKTK 790
                       :.|||         .|:|.:::|.::|            |:|:|....:|.|.:
  Fly   587 -----------SDDEK---------NKLESAIDESIKW------------LEQNPDADPEEYKKQ 619

Human   791 IKELNNTCEPVVTQ--------PKPKIESPKLERTPNGPNIDKKEE 828
            .|:|....:||:.:        |.|:          .|.:.|.|:|
  Fly   620 KKDLEAIVQPVIAKLYQGAGGAPPPE----------GGDDADLKDE 655

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HSPH1	NP_001273433.1	NBD_sugar-kinase_HSP70_actin	39..386	CDD:327376	131/348 (38%)
Hsc70-3	NP_001285139.1	HSPA5-like_NBD	29..403	CDD:212681	131/345 (38%)
		PTZ00009	32..643	CDD:240227	189/802 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810